Respiration-averaged CT versus standard CT attenuation maps for correction of 18F-NaF uptake on hybrid PET/CT (Preprint)

2020 ◽  
Author(s):  
Piotr Slomka
Keyword(s):  
Computed Tomography ◽  
Attenuation Correction ◽  
Single Phase ◽  
Free Breathing ◽  
Pet Ct ◽  
Ct Attenuation ◽  
Cine Ct ◽  
Ct System ◽  
Pet Reconstruction ◽  
The Impact

UNSTRUCTURED Purpose To evaluate the impact of a respiratory averaged computed tomography attenuation correction (RACTAC) instead of a standard single-phase computed tomography (CT) attenuation correction (CTAC) map on the quantitative measures of coronary 18F-NaF uptake in PET/CT. Methods This study comprised 23 patients who underwent 18F-NaF coronary PET in a hybrid PET/CT system, employing 18F-NaF (250MBq). All patients had two CT scans, a standard single-phase CTAC obtained during free-breathing, and a 4D cine-CT scan. From the Cine-CT acquisition, RACTAC maps were obtained by averaging all images acquired over 5 seconds. Two PET reconstruction protocols, one employing CTAC and another employing RACTAC for attenuation correction were considered in this study. Following reconstruction, the quantitative impact of employing RACTAC was assessed using maximum target-to-background (TBRMAX) and coronary microcalcification activity (CMA). Statistical differences were analyzed using reproducibility coefficients and Bland-Altman plots. Results In 23 patients, we evaluated 34 coronary lesions using PET reconstructions utilizing CTAC and RACTAC. There was good agreement between CTAC and RACTAC PET reconstructions for TBRMAX (median [Interquartile range, IQR]: CTAC = 1.65[1.23-2.38], RACTAC = 1.63[1.23-2.33], p=0.55), with coefficient of reproducibility of 0.18. The CMA agreement was similar (median [IQR]: CTAC = 0.10 [0-1.0], RACTAC= 0.15[0-1.03], p=0.55 with coefficient of reproducibility of 0.17 Conclusion Employing RACTAC maps does not affect the quantification of the coronary 18F-NaF uptake on PET/CT.

X-ray pulsing methods for reduced-dose computed tomography in PET/CT attenuation correction

2014 ◽  
Author(s):  
Uwe Wiedmann ◽  
V. Bogdan Neculaes ◽  
Dan Harrison ◽  
Evren Asma ◽  
Paul E. Kinahan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Attenuation Correction ◽  
X Ray ◽  
Reduced Dose ◽  
Pet Ct ◽  
Ct Attenuation

OPPORTUNISTIC EVALUATION OF BONE MINERAL DENSITY BY PET-CT IN HODGKIN LYMPHOMA PATIENTS

2019 ◽  
Vol 25 (9) ◽  
pp. 869-876 ◽  
Author(s):  
Bar Cohen ◽  
Nurith Hiller ◽  
Auryan Szalat ◽  
Vladimir Vainstein
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Hodgkin Lymphoma ◽  
Bone Mineral ◽  
Ct Scans ◽  
Mineral Density ◽  
Hounsfield Units ◽  
Positron Emission ◽  
Pet Ct ◽  
Ct Attenuation

Objective: Bone density loss and increased risk for osteoporosis are of concern in Hodgkin lymphoma (HL) patients. Routinely performed positron emission tomography–computed tomography (PET-CT) scans could be informative in assessing bone mineral density (BMD). Methods: This retrospective study included 80 adults with newly diagnosed HL treated with standard first-line chemotherapy regimens. PET-CT scans performed at diagnosis (PET-CT1), at the end of chemotherapy (PET-CT2), and at follow-up after remission (PET-CT3) were used to assess BMD changes by measuring lumbar vertebrae CT attenuation. A CT attenuation threshold of 160 Hounsfield units was used to define abnormal BMD. Results: Following chemotherapy, comparison of PET-CT2 with PET-CT1 revealed a mean (standard deviation) 14.2% (10.4%) BMD reduction ( P<.001). On PET-CT3 performed at 14.6 (3.25) months after the last course of chemotherapy, a slight improvement (4.6% [10.4%]) in comparison to PET-CT2 was noted. Twelve patients (15%) converted from normal baseline BMD on PET-CT1 to abnormal BMD after chemotherapy on PET-CT2. Age, baseline BMD, and steroid cumulative dose were associated with BMD decline and risk for abnormal BMD after chemotherapy. No clinical fractures were reported, and only one rib fracture was incidentally captured (1.25%). Conclusion: HL patients treated with common first-line chemotherapies demonstrate a significant decline in bone density on routine PET-CT scans. Opportunistic use of PET-CT scan has the potential to detect HL patients at high risk for developing osteoporosis and to guide clinicians regarding monitoring and intervention. Abbreviations: BMD = bone mineral density; CT = computed tomography; DXA = dual-energy X-ray absorptiometry; HL = Hodgkin lymphoma; HU = Hounsfield units; L = lumbarvertebra; PET-CT = positron emission tomography-computed tomography; T = thoracic vertebra

Etiology of Solitary Extrapulmonary Positron Emission Tomography and Computed Tomography Findings in Patients With Lung Cancer

2005 ◽  
Vol 23 (28) ◽  
pp. 6846-6853 ◽  
Author(s):  
Didier Lardinois ◽  
Walter Weder ◽  
Marina Roudas ◽  
Gustav K. von Schulthess ◽  
Michaela Tutic ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Positron Emission Tomography ◽  
Ct Imaging ◽  
Emission Tomography ◽  
Whole Body ◽  
Benign Tumors ◽  
Positron Emission ◽  
Pet Ct ◽  
The Impact

Purpose The aim of this prospective study was to assess the incidence and the nature of solitary extrapulmonary [18F] fluorodeoxyglucose (FDG) accumulations in patients with non–small-cell lung cancer (NSCLC) staged with integrated positron emission tomography and computed tomography (PET/CT) and to evaluate the impact on management. Patients and Methods A total of 350 patients with NSCLC underwent whole-body PET/CT imaging. All solitary extrapulmonary FDG accumulations were evaluated by histopathology, further imaging, or clinical follow-up. Results PET/CT imaging revealed extrapulmonary lesions in 110 patients. In 72 patients (21%), solitary lesions were present. A diagnosis was obtained in 69 of these patients, including 37 (54%) with solitary metastases and 32 (46%) with lesions unrelated to the lung primary. Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%). The six malignancies consisted of carcinoma of the breast in two patients, and carcinoma of the orbit, esophagus, prostate, and non-Hodgkin's lymphoma in one patient each. Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture. Conclusion Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.

Real-time MRI for assessment of PET/CT attenuation correction protocols

2008 ◽  
Author(s):  
James J. Hamill ◽  
A. Kino ◽  
D. Li ◽  
P. Weale ◽  
R. Jerecic ◽  
...  
Keyword(s):  
Real Time ◽  
Attenuation Correction ◽  
Pet Ct ◽  
Ct Attenuation
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