scholarly journals Self-Swabbing for Virological Confirmation of Influenza-Like Illness Among an Internet-Based Cohort in the UK During the 2014-2015 Flu Season: Pilot Study

2018 ◽  
Vol 20 (3) ◽  
pp. e71 ◽  
Author(s):  
Clare Wenham ◽  
Eleanor R Gray ◽  
Candice E Keane ◽  
Matthew Donati ◽  
Daniela Paolotti ◽  
...  
2017 ◽  
Author(s):  
Clare Wenham ◽  
Eleanor R Gray ◽  
Candice E Keane ◽  
Matthew Donati ◽  
Daniela Paolotti ◽  
...  

2017 ◽  
Author(s):  
Clare Wenham ◽  
Eleanor R Gray ◽  
Candice E Keane ◽  
Matthew Donati ◽  
Daniela Paolotti ◽  
...  

BACKGROUND Routine influenza surveillance, based on laboratory confirmation of viral infection, often fails to estimate the true burden of influenza-like illness (ILI) in the community because those with ILI often manage their own symptoms without visiting a health professional. Internet-based surveillance can complement this traditional surveillance by measuring symptoms and health behavior of a population with minimal time delay. Flusurvey, the UK’s largest crowd-sourced platform for surveillance of influenza, collects routine data on more than 6000 voluntary participants and offers real-time estimates of ILI circulation. However, one criticism of this method of surveillance is that it is only able to assess ILI, rather than virologically confirmed influenza. OBJECTIVE We designed a pilot study to see if it was feasible to ask individuals from the Flusurvey platform to perform a self-swabbing task and to assess whether they were able to collect samples with a suitable viral content to detect an influenza virus in the laboratory. METHODS Virological swabbing kits were sent to pilot study participants, who then monitored their ILI symptoms over the influenza season (2014-2015) through the Flusurvey platform. If they reported ILI, they were asked to undertake self-swabbing and return the swabs to a Public Health England laboratory for multiplex respiratory virus polymerase chain reaction testing. RESULTS A total of 700 swab kits were distributed at the start of the study; from these, 66 participants met the definition for ILI and were asked to return samples. In all, 51 samples were received in the laboratory, 18 of which tested positive for a viral cause of ILI (35%). CONCLUSIONS This demonstrated proof of concept that it is possible to apply self-swabbing for virological laboratory testing to an online cohort study. This pilot does not have significant numbers to validate whether Flusurvey surveillance accurately reflects influenza infection in the community, but highlights that the methodology is feasible. Self-swabbing could be expanded to larger online surveillance activities, such as during the initial stages of a pandemic, to understand community transmission or to better assess interseasonal activity.


2017 ◽  
Vol 46 (2) ◽  
pp. 182-194 ◽  
Author(s):  
Laura Pass ◽  
Carl W. Lejuez ◽  
Shirley Reynolds

Background: Depression in adolescence is a common and serious mental health problem. In the UK, access to evidence-based psychological treatments is limited, and training and employing therapists to deliver these is expensive. Brief behavioural activation for the treatment of depression (BATD) has great potential for use with adolescents and to be delivered by a range of healthcare professionals, but there is limited empirical investigation with this group. Aims: To adapt BATD for depressed adolescents (Brief BA) and conduct a pilot study to assess feasibility, acceptability and clinical effectiveness. Method: Twenty depressed adolescents referred to the local NHS Child and Adolescent Mental Health service (CAMHs) were offered eight sessions of Brief BA followed by a review around one month later. Self- and parent-reported routine outcome measures (ROMs) were collected at every session. Results: Nineteen of the 20 young people fully engaged with the treatment and all reported finding some aspect of Brief BA helpful. Thirteen (65%) required no further psychological intervention following Brief BA, and both young people and parents reported high levels of acceptability and satisfaction with the approach. The pre–post effect size of Brief BA treatment was large. Conclusions: Brief BA is a promising innovation in the treatment of adolescent depression. This approach requires further evaluation to establish effectiveness and cost effectiveness compared with existing evidence-based treatments for adolescent depression. Other questions concern the effectiveness of delivery in other settings and when delivered by a range of professionals.


2020 ◽  
Vol 32 (S1) ◽  
pp. 127-127
Author(s):  
Fatima Urzal ◽  
Ana Quintão ◽  
Catarina Santos ◽  
Nuno Moura ◽  
Ana Banazol ◽  
...  

IntroductionAs in other countries, Portuguese family caregivers have unmet needs regarding information and distress. START (STrAtegies for RelaTives) is a manual-based coping intervention for families of people with dementia, including coping strategies and stress-management components, by Livingston and colleagues (https://www.ucl.ac.uk/psychiatry/research/mental-health-older-people/projects/start). In the UK, START has been clinically effective, immediately and continuing even after 6-years, without increasing costs. Clinical training and supervision ensures treatment fidelity. In Portugal, these kind of interventions are less available and, when provided, are mostly supportive and fail to address coping strategies. Paradoxically, recruitment may also prove challenging.ObjectivesWe describe the development of the Portuguese translation of START, incorporating guidance from the UK team, and a pilot study of delivery to family caregivers of people with dementia. We will also discuss the challenges of recruiting participants and delivering the intervention.MethodWe translated the START intervention and recruited family caregivers from neurology and psychiatry outpatients, in a central hospital in Lisbon. Our baseline assessment included the Hospital Anxiety and Depression Scale and the Zarit Burden Interview. The pilot is still ongoing at time of submitting, so we focus on recruitment, baseline assessments and process issues.ResultsDuring a three-month period, we recruited six caregivers. Five were primary caregivers (spouses or adult children) who had been caring for their relatives for 2 up to 10 years. Two caregivers met the international cutoff for clinically relevant affective disorder . The most frequent motivators for taking part were learning to communicate with their relatives and increasing knowledge to build community resources. Overall, the subjective impression of the therapist in charge is that the intervention seems acceptable and promising.Discussion/ConclusionsThis pilot study will eventually lead to an improved version of the Portuguese version of the START manual. So far, the intervention seems appropriate for selected caregivers in Portugal. However, response to striking unmet needs, particularly basic home support, may need to precede interventions like START. We look forward to concluding the intervention study and analyzing the implementation challenges, as a basis to inform a wider-scale trial.


2015 ◽  
Vol 22 (20) ◽  
pp. 15821-15834 ◽  
Author(s):  
Karen Exley ◽  
Dominique Aerts ◽  
Pierre Biot ◽  
Ludwine Casteleyn ◽  
Marike Kolossa-Gehring ◽  
...  

2016 ◽  
Vol 51 (2) ◽  
pp. 225-231 ◽  
Author(s):  
C. Lowe ◽  
A. Worthington ◽  
F. Serracino-Inglott ◽  
R. Ashleigh ◽  
C. McCollum
Keyword(s):  

2019 ◽  
Author(s):  
Netta Weinstein ◽  
James Wilsdon ◽  
Jennifer Chubb ◽  
Geoff Haddock

The UK first introduced a national research assessment exercise in 1986, and methods of assessment continue to evolve. Following the 2016 Stern Review and further rounds of technical consultation, the UK higher education community is now preparing for the next Research Excellence Framework – REF 2021.Despite its importance in shaping UK research cultures, there is limited systematic and nuanced evidence about how academics across the sector view the REF, and which aspects are viewed favourably or unfavourably. The aims of this pilot study were twofold: first, it was designed to gather initial data to address this evidence gap; second, it was aimed at testing the feasibility of conducting a longitudinal study into academic and managerial attitudes towards the REF. We argue that further research to better understand the effects of the REF on research cultures, institutions, and individuals should be part of the evidence used to inform the development of future iterations of the exerciseThe Real Time REF Review Pilot Study was developed and delivered by a research team from Cardiff University and the University of Sheffield, in collaboration with Research England.


2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 974-975
Author(s):  
R Trotta ◽  
A Shoemaker ◽  
C Chancler ◽  
R Greysen ◽  
L Hudson ◽  
...  

1998 ◽  
Vol 4 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Ian H. Kunkler ◽  
Paul Rafferty ◽  
David Foreman ◽  
David Hill ◽  
Maureen Henry

A pilot study of tele-oncology linking a cancer centre with a rural district general hospital was carried out; it involved patients, physicians, surgeons, radiologists and nursing staff. Its purpose was to complement the existing on-site outpatient services, providing oncological advice on non-clinic days. During the six months of the trial, 18 videoconferences were conducted. Their median duration was 17 min range 7-40 . Eight videoconferences involved patients directly. Acceptability of videoconferencing to doctors, nurses and patients was assessed by a questionnaire. Patients and staff found the technique acceptable and were satisfied with the results. The addition of a teleradiology system to teleconsultations was found to be important when decisions on patient management were taken. Following the success of this pilot trial, larger studies of tele-oncology in the UK with measures of cost-effectiveness are needed.


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