scholarly journals Overcoming Clinical Inertia: A Randomized Clinical Trial of a Telehealth Remote Monitoring Intervention Using Paired Glucose Testing in Adults With Type 2 Diabetes

2015 ◽  
Vol 17 (7) ◽  
pp. e178 ◽  
Author(s):  
Deborah A Greenwood ◽  
Shelley A Blozis ◽  
Heather M Young ◽  
Thomas S Nesbitt ◽  
Charlene C Quinn
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Remote Monitoring ◽  
Clinical Inertia ◽  
Glucose Testing

Reducing inpatient hypoglycemia in the general wards using real-time CGM- the Glucose Telemetry system: A randomized clinical trial

2020 ◽  
Author(s):  
Lakshmi G. Singh ◽  
Medha Satyarengga ◽  
Isabel Marcano ◽  
William H. Scott ◽  
Lillian F. Pinault ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
High Risk ◽  
Randomized Clinical Trial ◽  
Real Time ◽  
Lower Percentage ◽  
Telemetry System ◽  
Glucose Testing ◽  
General Wards

OBJECTIVE: Use of real-time continuous glucose monitoring (RT-CGM) systems in the inpatient setting is considered investigational. The objective of this study was to evaluate whether RT-CGM, using the glucose telemetry system (GTS), can prevent hypoglycemia in the general wards. <p>RESEARCH DESIGN AND METHODS: In a randomized clinical trial, insulin-treated patients at high risk for hypoglycemia with type 2 diabetes were recruited. Participants were randomized to RT-CGM/GTS or point of care (POC) blood glucose testing. The primary outcome was difference in inpatient hypoglycemia.</p> <p>RESULTS: Seventy-two participants were included in this interim analysis, 36 in the RT-CGM/GTS group and 36 in the POC group. RT-CGM/GTS group experienced fewer hypoglycemic events (<70 mg/dL) per patient (0.67 events per patient, 95% CI 0.34-1.30 versus 1.69 events per patient, 95% CI 1.11-2.58, <i>p</i>=0.024) and fewer clinically significant hypoglycemic events (<54 mg/dL) per patient (0.08 events per patient, 95% CI 0.03-0.26 versus 0.75, 95% CI 0.51-1.09, <i>p</i>=0.003). RT-CGM/GTS had lower percentage of time spent below range <70 mg/dl (0.40%, 95% CI 0.18%-0.92% versus 1.88%, 95% CI 1.26%-2.81%, <i>p</i>=0.002) and <54 mg/dL (0.05%, 95% CI 0.01%-0.43% versus 0.82%, 95% CI 0.47%-1.43%, <i>p</i>=0.017) compared to POC group. No differences in nocturnal hypoglycemia, time in range 70-180 mg/dL, time above range >180-250 mg/dL and >250 mg/dL were found between the groups. RT-CGM/GTS group had no prolonged hypoglycemia compared to 0.20 episodes <54mg/dL and 0.40 episodes <70mg/dL per patient in the POC group. </p> <p>CONCLUSIONS: RT-CGM/GTS can decrease hypoglycemia among hospitalized high risk insulin treated patients with type 2 diabetes.</p>

scholarly journals Reducing inpatient hypoglycemia in the general wards using real-time CGM- the Glucose Telemetry system: A randomized clinical trial

2020 ◽  
Author(s):  
Lakshmi G. Singh ◽  
Medha Satyarengga ◽  
Isabel Marcano ◽  
William H. Scott ◽  
Lillian F. Pinault ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
High Risk ◽  
Randomized Clinical Trial ◽  
Real Time ◽  
Lower Percentage ◽  
Telemetry System ◽  
Glucose Testing ◽  
General Wards

OBJECTIVE: Use of real-time continuous glucose monitoring (RT-CGM) systems in the inpatient setting is considered investigational. The objective of this study was to evaluate whether RT-CGM, using the glucose telemetry system (GTS), can prevent hypoglycemia in the general wards. <p>RESEARCH DESIGN AND METHODS: In a randomized clinical trial, insulin-treated patients at high risk for hypoglycemia with type 2 diabetes were recruited. Participants were randomized to RT-CGM/GTS or point of care (POC) blood glucose testing. The primary outcome was difference in inpatient hypoglycemia.</p> <p>RESULTS: Seventy-two participants were included in this interim analysis, 36 in the RT-CGM/GTS group and 36 in the POC group. RT-CGM/GTS group experienced fewer hypoglycemic events (<70 mg/dL) per patient (0.67 events per patient, 95% CI 0.34-1.30 versus 1.69 events per patient, 95% CI 1.11-2.58, <i>p</i>=0.024) and fewer clinically significant hypoglycemic events (<54 mg/dL) per patient (0.08 events per patient, 95% CI 0.03-0.26 versus 0.75, 95% CI 0.51-1.09, <i>p</i>=0.003). RT-CGM/GTS had lower percentage of time spent below range <70 mg/dl (0.40%, 95% CI 0.18%-0.92% versus 1.88%, 95% CI 1.26%-2.81%, <i>p</i>=0.002) and <54 mg/dL (0.05%, 95% CI 0.01%-0.43% versus 0.82%, 95% CI 0.47%-1.43%, <i>p</i>=0.017) compared to POC group. No differences in nocturnal hypoglycemia, time in range 70-180 mg/dL, time above range >180-250 mg/dL and >250 mg/dL were found between the groups. RT-CGM/GTS group had no prolonged hypoglycemia compared to 0.20 episodes <54mg/dL and 0.40 episodes <70mg/dL per patient in the POC group. </p> <p>CONCLUSIONS: RT-CGM/GTS can decrease hypoglycemia among hospitalized high risk insulin treated patients with type 2 diabetes.</p>

scholarly journals Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naive Patients With Type 2 Diabetes: A randomized clinical trial

Diabetes Care ◽  
2011 ◽  
Vol 34 (7) ◽  
pp. 1591-1594 ◽  
Author(s):  
M. G. Ramos-Zavala ◽  
M. Gonzalez-Ortiz ◽  
E. Martinez-Abundis ◽  
J. A. Robles-Cervantes ◽  
R. Gonzalez-Lopez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Insulin Secretion ◽  
Randomized Clinical Trial ◽  
Metabolic Control ◽  
Drug Naïve

scholarly journals Inverse Association of Peripheral Orexin-A with Insulin Resistance in Type 2 Diabetes Mellitus: A Randomized Clinical Trial

2017 ◽  
Vol 14 (2-3) ◽  
pp. 301-310 ◽  
Author(s):  
Mitra Zarifkar ◽  
Sina Noshad ◽  
Mona Shahriari ◽  
Mohsen Afarideh ◽  
Elias Khajeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Type 2 Diabetes Mellitus ◽  
Randomized Clinical Trial ◽  
Inverse Association ◽  
Orexin A
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