scholarly journals Extrahepatic Autoimmune Diseases are Prevalent in Autoimmune Hepatitis Patients and Their First-Degree Relatives: Survey Study

2018 ◽  
Vol 7 (2) ◽  
pp. e18 ◽  
Author(s):  
Rachel Fogel ◽  
Megan Comerford ◽  
Prianka Chilukuri ◽  
Eric Orman ◽  
Naga Chalasani ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Autoimmune Hepatitis ◽  
Survey Study ◽  
First Degree Relatives

scholarly journals Extrahepatic Autoimmune Diseases are Prevalent in Autoimmune Hepatitis Patients and Their First-Degree Relatives: Survey Study (Preprint)

2017 ◽  
Author(s):  
Rachel Fogel ◽  
Megan Comerford ◽  
Prianka Chilukuri ◽  
Eric Orman ◽  
Naga Chalasani ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Autoimmune Hepatitis ◽  
Survey Study ◽  
Categorical Variables ◽  
Healthy Controls ◽  
Continuous Variables ◽  
Degree Relative ◽  
First Degree Relatives ◽  
Autoimmune Conditions ◽  
History Of

BACKGROUND Concurrent autoimmune illnesses contribute to increased medical burden and reduced quality of life in patients with autoimmune hepatitis (AIH). The frequency of coexisting autoimmune conditions among North American patients with AIH and their families remains incomplete. Challenges associated with disease capture in the electronic medical record, high study costs, and geographic spread of patients are formidable barriers to understanding the extent of concurrent autoimmune conditions in these groups. OBJECTIVE This objective of this study was to examine the frequency of extrahepatic autoimmune diseases (EHAD) among AIH cases and healthy controls as well as their first-degree relatives using social networking sites (SNS). METHODS We developed a 53-question survey detailing the history of autoimmune diseases. A survey link was posted at routine intervals within specific Web-based cohorts on SNS. Healthy controls, without self-reported autoimmune liver disease, were recruited from Amazon’s Mechanical Turk. Continuous variables were summarized using medians and P values obtained with the Wilcoxon rank-sum test. Categorical variables were compared using the chi-square test. RESULTS Compared with controls (n=1162), cases (n=306) were more likely to be older (median age: 49 vs 33 years), female (284/306, 92.81% vs 955/1162, 82.18%), and have an EHAD (128/306, 41.83% vs 218/1162, 18.76%; P=.001). The most frequent EHADs among cases were thyroid disease (49/306, 16.01% ), Sjögren syndrome (27/306, 8.82%), Raynaud phenomenon (23/306, 7.52%), and psoriasis (22/306, 7.19%). Overall, 55.88% (171/306) of cases and 35.71% (1601/4484) of controls reported at least 1 first-degree relative (FDR) with a history of EHAD (P=.001). Cases had a significantly higher risk of EHAD than controls after the adjustment for age, sex, race, and body mass index: odds ratio 2.46 (95% CI 1.8-3.3); P=.001. CONCLUSIONS Patients with AIH report higher prevalence of coexistent EHAD than healthy controls, and their FDRs are also more likely to have autoimmune disorders.

Autoimmune hepatitis

2010 ◽  
pp. 2460-2464
Author(s):  
H.J.F. Hodgson
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Autoimmune Hepatitis ◽  
Chronic Inflammation ◽  
Case History ◽  
Plasma Cells ◽  
Portal Tract ◽  
History Of

Case History—A 24 yr old woman presenting with a short history of jaundice. Autoimmune hepatitis describes chronic inflammation in the liver attributed to immune responses against self-antigens in the liver, typically in the form of a marked portal tract infiltrate containing both plasma cells and T cells. It usually affects women (female:male, 8:1), is often familial, and 60% of patients have other autoimmune diseases (e.g. thyroiditis, type 1 diabetes) in addition....

scholarly journals Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives

2008 ◽  
Vol 31 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Susan L. Neuhausen ◽  
Linda Steele ◽  
Sarah Ryan ◽  
Maryam Mousavi ◽  
Marie Pinto ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Autoimmune Diseases ◽  
First Degree Relatives

Associated Autoimmune Diseases in First Degree Relatives of Type 1 Diabetic Children

2010 ◽  
Vol 2010 (1) ◽  
pp. 13 ◽  
Author(s):  
A.M. Murad ◽  
M.M. Murad ◽  
J.M. Khudhairi ◽  
M.M. Murad ◽  
A.H. Tarish
Keyword(s):  
Autoimmune Diseases ◽  
First Degree Relatives ◽  
Diabetic Children

Concurrent Autoimmune Diseases in Patients With Autoimmune Hepatitis

2010 ◽  
Vol 44 (3) ◽  
pp. 208-213 ◽  
Author(s):  
Andreas Teufel ◽  
Arndt Weinmann ◽  
George J. Kahaly ◽  
Catherine Centner ◽  
Anja Piendl ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Autoimmune Hepatitis

Manifest hyperthyroidism in patient with autoimmune hepatitis (clinical observation)

2021 ◽  
pp. 52-56
Author(s):  
M. A. Livzan ◽  
O. V. Gaus ◽  
D. A. Gavrilenko
Keyword(s):  
Autoimmune Diseases ◽  
Autoimmune Hepatitis ◽  
Clinical Guidelines ◽  
Thyroid Disease ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Clinical Observation ◽  
Primary Biliary Cholangitis ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Among patients with autoimmune hepatitis concomitant autoimmune diseases occur in 40 % of cases. The most commonly associated autoimmune hepatitis is primary biliary cholangitis, primary sclerosing cholangitis and thyroid disease. With regard to the association of autoimmune liver diseases with each other there is experience in management and this is reflected in the clinical guidelines. Information on the features of comorbidity in autoimmune hepatitis and autoimmune thyroid diseases is very limited. This article presents our own clinical observation of the manifestation of thyrotoxicosis against the background of autoimmune hepatitis.

Autoimmune diseases in patients with pemphigus and their first-degree relatives

2011 ◽  
Vol 50 (7) ◽  
pp. 827-831 ◽  
Author(s):  
Yael A. Leshem ◽  
Varda Katzenelson ◽  
Gil Yosipovitch ◽  
Michael David ◽  
Daniel Mimouni
Keyword(s):  
Autoimmune Diseases ◽  
First Degree Relatives

scholarly journals Xenobiotic Exposure and Autoimmune Hepatitis

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Kathleen M. Gilbert
Keyword(s):  
Environmental Factors ◽  
Autoimmune Diseases ◽  
Autoimmune Hepatitis ◽  
Environmental Pollutants ◽  
Xenobiotic Exposure

Although genetics contributes to the development of autoimmune diseases, it is clear that “environmental” factors are also required. These factors are thought to encompass exposure to certain drugs and environmental pollutants. This paper examines the mechanisms that normally maintain immune unresponsiveness in the liver and discusses how exposure to certain xenobiotics such as trichloroethylene may disrupt those mechanisms and promote autoimmune hepatitis.

scholarly journals Autoimmune diseases and autoantibodies in pediatric patients and their first-degree relatives with immunoglobulin A deficiency

2015 ◽  
Vol 55 (3) ◽  
pp. 197-202
Author(s):  
Kristine Fahl ◽  
Clovis A. Silva ◽  
Antonio C. Pastorino ◽  
Magda Carneiro-Sampaio ◽  
Cristina M.A. Jacob
Keyword(s):  
Autoimmune Diseases ◽  
Pediatric Patients ◽  
Immunoglobulin A ◽  
First Degree Relatives
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