scholarly journals Olfactory training and visual stimulation assisted by web-application in patients with persistent olfactory dysfunction after SARS-CoV-2 infection: observational study. (Preprint)

10.2196/29583 ◽  
2021 ◽  
Author(s):  
Fabrice Denis ◽  
Anne-Lise Septans ◽  
Lea Periers ◽  
Jean-Michel Maillard ◽  
Florian Legoff ◽  
...  
Keyword(s):  
Observational Study ◽  
Web Application ◽  
Visual Stimulation ◽  
Olfactory Dysfunction ◽  
Olfactory Training

scholarly journals Olfactory training and visual stimulation assisted by web-application in patients with persistent olfactory dysfunction after SARS-CoV-2 infection: observational study. (Preprint)

2021 ◽  
Author(s):  
Fabrice Denis ◽  
Anne-Lise Septans ◽  
Lea Periers ◽  
Jean-Michel Maillard ◽  
Florian Legoff ◽  
...  
Keyword(s):  
Web Application ◽  
Primary Outcome ◽  
Visual Stimulation ◽  
Real Life ◽  
Olfactory Dysfunction ◽  
High Concentration ◽  
Real Life Data ◽  
The Mean ◽  
Mean Time ◽  
Olfactory Training

BACKGROUND Persistent olfactory dysfunction (OD) is a significant complication of SARS-CoV-2 infection. Olfactory training (OT) using aromatic oils are recommended to improve olfactory recovery, but quantitative data are missing. OBJECTIVE We aimed to quantify the benefit of OT associated with visual stimulation assisted by a dedicated web-application on patients with 1-month or more OD. METHODS We performed an observational real-life data-based study on a cohort of patients with at least 1-month persistent OD included between 1/30/21 and 3/26/2021. Analysis was performed after a 4-weeks mean time of OT and at least 500 patients assessable for primary outcome. Participants exposed themselves twice daily to odors from four high concentration oils and visual stimulation assisted by a dedicated web-application. Improvement was defined as a 2/10 points increase on self-assessed olfactory visual analogue scale. RESULTS 548 were assessable for primary outcome assessment. The mean baseline self-assessed olfactory score was 1.9/10 (SD 1.7) and increase to 4.6 (SD 2.8) beyond a mean time of olfactory training of 27.7 days (SD 17.2). Olfactory training was associated with at least 2-points increase in 64.2% (n=352). The rate of patients with improvement was higher in patients having trained for more than 28 days versus patients having trained for less than 28 days (72.2% vs 59.0% respectively, p=.002). The benefit was observed regardless of the duration of the OD. CONCLUSIONS OT associated with visual stimulation assisted by a dedicated web-application was associated with significant improvement in olfaction, especially if OT duration was superior to 28 days. CLINICALTRIAL NCT04806880

scholarly journals Olfactory training and visual stimulation assisted by web-application in patients with persistent olfactory dysfunction after SARS-CoV-2 infection: observational study.

2021 ◽  
Author(s):  
Fabrice Denis ◽  
Anne-Lise Septans ◽  
Lea Periers ◽  
Jean-Michel Maillard ◽  
Florian Legoff ◽  
...  
Keyword(s):  
Web Application ◽  
Primary Outcome ◽  
Visual Stimulation ◽  
Real Life ◽  
Olfactory Dysfunction ◽  
High Concentration ◽  
Real Life Data ◽  
The Mean ◽  
Mean Time ◽  
Olfactory Training

Background: Persistent olfactory dysfunction (OD) is a significant complication of SARS-CoV-2 infection. Olfactory training (OT) using aromatic oils are recommended to improve olfactory recovery, but quantitative data are missing. Objective: We aimed to quantify the benefit of OT associated with visual stimulation assisted by a dedicated web-application on patients with 1-month or more OD. Methods: We performed an observational real-life data-based study on a cohort of patients with at least 1-month persistent OD included between 1/30/21 and 3/26/2021. Analysis was performed after a 4-weeks mean time of OT and at least 500 patients assessable for primary outcome. Participants exposed themselves twice daily to odors from four high concentration oils and visual stimulation assisted by a dedicated web-application. Improvement was defined as a 2/10 points increase on self-assessed olfactory visual analogue scale. Results: 548 were assessable for primary outcome assessment. The mean baseline self-assessed olfactory score was 1.9/10 (SD 1.7) and increase to 4.6 (SD 2.8) beyond a mean time of olfactory training of 27.7 days (SD 17.2). Olfactory training was associated with at least 2-points increase in 64.2% (n=352). The rate of patients with improvement was higher in patients having trained for more than 28 days versus patients having trained for less than 28 days (72.2% vs 59.0% respectively, p=.002). The kinetic of improvement was 8 days faster in hyposmic than in anosmic patients (p<.001). The benefit was observed regardless of the duration of the OD. Conclusions: OT associated with visual stimulation assisted by a dedicated web-application was associated with significant improvement in olfaction, especially if OT duration was superior to 28 days.

scholarly journals Olfactory Training and Visual Stimulation Assisted by a Web-Application for Patients With Persistent Olfactory Dysfunction After SARS-CoV-2 Infection

2021 ◽  
Author(s):  
Fabrice Denis ◽  
Anne-Lise Septans ◽  
Léa Périers ◽  
Jean-Michel Maillard ◽  
Florian Legoff ◽  
...  
Keyword(s):  
Web Application ◽  
Visual Stimulation ◽  
Olfactory Dysfunction ◽  
Severe Toxicity ◽  
High Concentration ◽  
Point Increase ◽  
Spontaneous Improvement ◽  
Study Participants ◽  
Mild Toxicity ◽  
Olfactory Training

Abstract IntroductionWe aimed to quantify the benefit of olfactory training and visual stimulation assisted by a dedicated web application for patients who experienced olfactory dysfunction for ≥1 month after Sars-Cov-2 infection and compared it with published cohorts of spontaneous recoveries.Materials and MethodsWe performed a prospective observational study. Participants performed olfactory training and visual stimulation assisted by a dedicated web-application. Improvement was defined as a 2-point increase on a 10-point, self-assessed olfactory visual analogue scale.ResultsIn total, 1155 patients were assessable. Improvement was observed in patients who trained 4 weeks and 4 to 8 weeks with high concentration oils in 63.0% (58/92) and 72.9% (137/188) respectively, whereas in historical cohorts, a spontaneous improvement was observed in 7% to 27% without training respectively (p<.001). The benefit was observed regardless of the duration of the olfactory dysfunction. No or mild toxicity was reported by 86.6% (662/764) of patients. Severe toxicity leading to stop training was reported in 0.5% of patients.ConclusionsOlfactory training and visual stimulation assisted by a dedicated web application seems to accelerate olfactive improvement in persistent olfactory dysfunction following SARS-CoV-2 infection, especially after 30 days of olfactory training. Maximal duration of training appeared to be 8 weeks.

scholarly journals Postinfectious Olfactory Dysfunction: Oral Steroids and Olfactory Training versus Olfactory Training Alone: Is There any Benefit from Steroids?

ORL ◽  
2021 ◽  
pp. 1-8
Author(s):  
Sotiria Genetzaki ◽  
Evangelia Tsakiropoulou ◽  
Vasilios Nikolaidis ◽  
Konstantinos Markou ◽  
Iordanis Konstantinidis
Keyword(s):  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Line Treatment ◽  
First Line ◽  
Olfactory Testing ◽  
Significant Difference ◽  
Oral Steroids ◽  
Group A ◽  
Olfactory Training ◽  
First Line Treatment

<b><i>Introduction:</i></b> There are limited treatment options for postinfectious olfactory dysfunction (PIOD). Olfactory training has recently been used in clinical practice, but no medical treatment is widely accepted. Although there is weak evidence for their value, some physicians use oral corticosteroids as first-line treatment. The aim of this study was to compare combined oral methylprednisolone and olfactory training with olfactory training alone in the management of PIOD. <b><i>Methods:</i></b> This prospective cohort study included 131 patients with PIOD over a 2-year period before the COVID-19 pandemic. Seventy-eight patients who were treated with oral methylprednisolone and olfactory training (group A) were compared with 53 patients who were treated with olfactory training only (group B). Olfactory function was evaluated with “Sniffin’ Sticks” at baseline and 2, 8, and 16 weeks after initial assessment. Patients who improved after steroid treatment underwent magnetic resonance imaging of the paranasal sinuses, skin prick tests, lung spirometry, and sputum eosinophil assessment. <b><i>Results:</i></b> Oral steroids improved 19.23% of patients (<i>n</i> = 15) of group A. History, clinical evaluation, imaging, and laboratory tests identified an inflammatory background in half of them (<i>n</i> = 8). The remaining 7 had no findings of nasal inflammation, and all had a short history of olfactory dysfunction. Both groups significantly improved in olfactory testing results at the end of the olfactory training scheme without significant difference between them. <b><i>Conclusions:</i></b> The percentage of improved patients after oral methylprednisolone was relatively low to suggest it as first-line treatment. Half of the improved patients had an underlying upper airway inflammatory condition not related to the infection that caused the acute loss of olfactory function.

Olfactory Training Using Heavy and Light Weight Molecule Odors

Perception ◽  
2016 ◽  
Vol 46 (3-4) ◽  
pp. 343-351 ◽  
Author(s):  
Sophia C. Poletti ◽  
Elisabeth Michel ◽  
Thomas Hummel
Keyword(s):  
Molecular Weight ◽  
Olfactory Dysfunction ◽  
Light Weight ◽  
Short Term ◽  
Olfactory Loss ◽  
Short Term Exposure ◽  
Before And After ◽  
Phenyl Ethyl Alcohol ◽  
A Prospective Study ◽  
Olfactory Training

Background Repeated short-term exposure to odors is known to improve olfaction in patients with acquired olfactory dysfunction. The aim was to find out whether differences in molecular weight of odors used for olfactory training influences olfaction. We hypothesized a greater improvement following training with light weight molecule (LWM) odors. Methods A prospective study was performed in patients with posttraumatic (PTOL) and postviral olfactory loss (PVOL). Olfactory training was performed over a period of 5 months. One group ( n = 48) used four odors containing heavy weight molecules (HWM; >150 g/mol) and another ( n = 48) containing LWM (<150 g/mol). Olfaction was tested before and after the training using the Sniffin’ Sticks test. Results Olfactory training was associated with olfactory improvement, with the improvement in PVOL patients being three times greater than that seen in the PTOL group. Compared with LWM training, HWM training was associated with a significantly greater improvement in Phenyl Ethyl Alcohol (PEA) threshold scores in PVOL patients; however, no such improvement could be shown for other subtests or in PTOL patients. Conclusion Overall, training was associated with olfactory improvement. With the exception of threshold scores in PVOL, there were no significant differences between LWM and HWM groups.

scholarly journals Effects of olfactory training on resting-state effective connectivity in patients with posttraumatic olfactory dysfunction

2020 ◽  
Vol 80 (4) ◽  
pp. 381-388
Author(s):  
Kianoosh Hosseini ◽  
Arash Zare-Sadeghi ◽  
Saeed Sadigh-Eteghad ◽  
Marjan Mirsalehi ◽  
Davood Khezerloo
Keyword(s):  
Resting State ◽  
Effective Connectivity ◽  
Olfactory Dysfunction ◽  
Olfactory Training

scholarly journals Clinical effects of two combinations of olfactory agents on olfactory dysfunction after upper respiratory tract infection during olfactory training

2020 ◽  
Vol 66 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Xiao-Feng Qiao ◽  
Yin-Huan Bai ◽  
Guo-Ping Wang ◽  
Xin Li ◽  
Wei Zheng
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Therapeutic Effect ◽  
Odor Discrimination ◽  
Olfactory Dysfunction ◽  
Clinical Effects ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Olfactory Training

SUMMARY OBJECTIVE To compare two combinations of olfactory agents for olfactory training therapy of olfactory dysfunction after upper respiratory tract infection (URTI) and investigate the influencing factors on clinical effects. METHODS 125 patients with olfactory dysfunction were randomly divided into two groups: test and control. During the olfactory training, four odors were used in both groups. The olfactory training lasted for 24 weeks. Then, participants were tested using Sniffin’ Sticks and threshold-discrimination-identification (TDI) composite scoring before treatment and at 1, 3, and 6 months after treatment. The TDI scores were compared at different time points between the groups and within them, and influence factors were analyzed. RESULTS There was no significant difference in TDI scores between both groups. Furthermore, TDI scores did not significantly change after one month of treatment in either of the groups. After 3 and 6 months of treatment, TDI scores both significantly increased, and the odor discrimination and identification abilities significantly strengthened in both groups; however, the odor thresholds did not improve. The course of the disease was a significant influencing factor on the therapeutic effect of olfactory training for both groups. CONCLUSION The combination of essential balm, vinegar, alcohol, and rose perfume for olfactory training, which are scents commonly found in daily life, can effectively cure URTI-induced olfactory dysfunction, and significantly improve the odor discrimination and identification abilities. Furthermore, prolonging the treatment time can help with the recovery of olfactory functions, and earlier olfactory training can improve the therapeutic effect.

Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction

2013 ◽  
Vol 123 (12) ◽  
pp. E85-E90 ◽  
Author(s):  
Iordanis Konstantinidis ◽  
Evangelia Tsakiropoulou ◽  
Paschalia Bekiaridou ◽  
Chrysa Kazantzidou ◽  
Jannis Constantinidis
Keyword(s):  
Olfactory Dysfunction ◽  
Post Traumatic ◽  
Olfactory Training
Sign in / Sign up

Export Citation Format

Share Document