scholarly journals Advances in digital psychiatry: Towards an extended definition of major depressive disorder symptomatology (Preprint)

10.2196/27908 ◽  
2021 ◽  
Author(s):  
Nayra Anna Martin-Key ◽  
Dan-Mircea Mirea ◽  
Tony Olmert ◽  
Jason Cooper ◽  
Sung Yeon Sarah Han ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Definition Of

A simpler definition of major depressive disorder

2009 ◽  
Vol 40 (3) ◽  
pp. 451-457 ◽  
Author(s):  
M. Zimmerman ◽  
J. N. Galione ◽  
I. Chelminski ◽  
J. B. McGlinchey ◽  
D. Young ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Somatic Symptoms ◽  
Structured Interview ◽  
Major Depressive ◽  
Medically Ill ◽  
Treatment Providers ◽  
Dsm Iv ◽  
Definition Of ◽  
High Level

BackgroundThe DSM-IV symptom criteria for major depressive disorder (MDD) are somewhat lengthy, with many studies showing that treatment providers have difficulty recalling all nine symptoms. Moreover, the criteria include somatic symptoms that are difficult to apply in patients with medical illnesses. In a previous report, we developed a briefer definition of MDD that was composed of the mood and cognitive symptoms of the DSM-IV criteria, and found high levels of agreement between the simplified and full DSM-IV definitions. The goal of the present study was to replicate these findings in another large sample of psychiatric out-patients and to extend the findings to other patient samples.MethodWe interviewed 1100 psychiatric out-patients and 210 pathological gamblers presenting for treatment and 1200 candidates for bariatric surgery. All patients were interviewed by a diagnostic rater who administered a semi-structured interview. We inquired about all symptoms of depression for all patients.ResultsIn all three samples high levels of agreement were found between the DSM-IV and the simpler definition of MDD. Summing across all 2510 patients, the level of agreement between the two definitions was 95.5% and the κ coefficient was 0.87.ConclusionsAfter eliminating the four somatic criteria from the DSM-IV definition of MDD, a high level of concordance was found between this simpler definition and the original DSM-IV classification. This new definition offers two advantages over the current DSM-IV definition – it is briefer and it is easier to apply with medically ill patients because it is free of somatic symptoms.

Validity of a simpler definition of major depressive disorder

2010 ◽  
Vol 27 (10) ◽  
pp. 977-981 ◽  
Author(s):  
Mark Zimmerman ◽  
Janine N. Galione ◽  
Iwona Chelminski ◽  
Diane Young ◽  
Kristy Dalrymple ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Definition Of

scholarly journals Migraine associated with early onset postpartum depression in women with major depressive disorder

2021 ◽  
Author(s):  
Katherine Gordon-Smith ◽  
Paul Ridley ◽  
Amy Perry ◽  
Nicholas Craddock ◽  
Ian Jones ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Postpartum Depression ◽  
Depressive Disorder ◽  
Hormonal Changes ◽  
Genetic Determinants ◽  
Major Depressive ◽  
History Of ◽  
Specific Association ◽  
Definition Of ◽  
Reproductive Events

AbstractMajor depressive disorder (MDD) and migraine are both more common among women than men. Women’s reproductive years are associated with increased susceptibility to recurrence of both conditions, suggesting a potential role of sex hormones in aetiology. We examined associations between comorbid migraine and clinical features of MDD in women, including relationships with lifetime reproductive events such as childbirth. Lifetime clinical characteristics and reproductive events in a well-characterised sample of 222 UK women with recurrent MDD, with (n = 98) and without (n = 124) migraine were compared. Women had all been recruited as part of a UK-based ongoing programme of research into the genetic and non-genetic determinants of mood disorders. Multivariate analysis showed a specific association between the lifetime presence of migraine and postpartum depression (PPD) within 6 weeks of delivery (OR = 2.555; 95% CI: 1.037–6.295, p = 0.041). This association did not extend to a broader definition of PPD with onset up to 6 months postpartum. All other factors included in the analysis were not significantly associated with the presence of migraine: family history of depression, younger age at depression onset, history of suicide attempt and severe premenstrual syndrome symptoms. The finding that women with MDD and comorbid migraine may be particularly sensitive to hormonal changes early in the postpartum period leads to aetiological hypotheses and suggests this group may be useful for future studies attempting to characterise PPD and MDD phenotypes. The refinement of such phenotypes has implications for individualising risk and treatment and for future biological and genetic studies.

Advances in digital psychiatry: Towards an extended definition of major depressive disorder symptomatology (Preprint)

2021 ◽  
Author(s):  
Nayra Anna Martin-Key ◽  
Dan-Mircea Mirea ◽  
Tony Olmert ◽  
Jason Cooper ◽  
Sung Yeon Sarah Han ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Decision Making ◽  
Clinical Symptoms ◽  
Model Performance ◽  
Emotional Instability ◽  
Major Depressive ◽  
Digital Assessment ◽  
Wide Range ◽  
Definition Of

BACKGROUND Diagnosing major depressive disorder (MDD) is challenging, with diagnostic manuals failing to capture the wide range of clinical symptoms that are endorsed by individuals with the condition. OBJECTIVE The aim of this study was to provide evidence for an extended definition of MDD symptomatology. METHODS Symptom data were collected via a digital assessment that was developed for the Delta Study [1]. Random forest classification with nested cross-validation was used to distinguish between individuals with MDD and those with subthreshold symptomatology of the disorder using i) disorder-specific symptoms and ii) transdiagnostic symptoms. The diagnostic performance of the Patient Health Questionnaire-9 (PHQ-9) was also examined. RESULTS A depression-specific model demonstrated good predictive performance when distinguishing between individuals with MDD (n = 64) and those with subthreshold depression (n = 140) (AUC = .89; sensitivity = 82.4%; specificity = 81.3%; accuracy = 81.6%). The inclusion of transdiagnostic symptoms of psychopathology, including symptoms of depression, generalized anxiety disorder, insomnia, emotional instability, and panic disorder, improved the model performance (AUC = .95; sensitivity = 86.5%; specificity = 90.8%; accuracy = 89.5%). The PHQ-9 was excellent at identifying MDD but over diagnosed the condition (sensitivity = 92.2%; specificity = 54.3%; accuracy = 66.2%). CONCLUSIONS Our findings are in line with the notion that current diagnostic practices may present an overly narrow conception of mental health. Further, our study provides proof-of-concept support for the clinical utility of a digital assessment to inform clinical decision-making in the evaluation of MDD.

scholarly journals Emotional Blunting in Patients With Major Depressive Disorder: A Brief Non-systematic Review of Current Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongzhe Ma ◽  
Min Cai ◽  
Huaning Wang
Keyword(s):  
Systematic Review ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Emotional Response ◽  
Major Depressive ◽  
Clinical Assessments ◽  
Medication Discontinuation ◽  
Definition Of ◽  
Higher Doses ◽  
Prevalent Symptom

Emotional blunting is frequently reported by patients with major depressive disorder (MDD) and has been identified as one of the most prominent side effects of antidepressants leading to medication discontinuation. However, antidepressant-induced emotional blunting remains largely unexplored—there lacks a clinical definition of this condition, and no agreeing conclusion has been reached regarding its etiology. Current research suggests that the onset of diminished emotional response may be related to antidepressant dose, with higher doses being more likely to induce emotional blunting. Consequently, most clinicians either reduce the dose or switch to another drug when treating this symptom. Overall, more comprehensive clinical assessments or interviews specifically designed to evaluate antidepressant-induced emotional blunting in MDD patients are in need to elucidate the neuropsychological mechanisms behind this increasingly prevalent symptom.

Assessing Pragmatic Language Skills in Adults with Major Depressive Disorder: An Exploratory Study

2021 ◽  
pp. 1-14
Author(s):  
Maria Clelia Zurlo ◽  
Maura Ruggiero
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Language Skills ◽  
Pragmatic Language ◽  
Major Depressive ◽  
Pragmatic Language Skills ◽  
Healthy Control ◽  
Indirect Requests ◽  
Education And Employment ◽  
Definition Of

Introduction: There is increasing evidence that major depressive disorder (MDD) is associated with significant pragmatic language impairments. However, there is a lack of studies that use standardized tools and simultaneously investigate all pragmatic language skills among MDD patients. The aim of this study was to propose a more thorough investigation of all pragmatic language skills in patients with MDD. Methods: Twenty adults (aged 22–65) with a DSM-5 diagnosis of MDD were assessed using BLED Santa Lucia (Batteria sul Linguaggio dell’Emisfero Destro Santa Lucia), a battery designed to evaluate pragmatic language skills (comprehension of inferences, of picture and written metaphors, of indirect requests, of humoristic expressions, and of prosody). The performance of the MDD participants on all BLED Santa Lucia subscales was compared to 20 healthy control subjects (aged 20–60) matched for gender, age, years of education, and employment status. Results: MDD patients performed poorer than controls in comprehension of inferences (p < 0.01), picture metaphors (p < 0.001), written metaphors (p < 0.001), indirect requests (p < 0.01), humoristic expression (p < 0.05), and prosody (p < 0.05). Conclusions: All pragmatic language skills can be significantly impaired in MDD patients. A valid assessment of all pragmatic language skills can allow, for each patient, the definition of a specific profile of risk and protective factors before and during psychotherapy.

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