scholarly journals Information and scientific impact of Advanced Therapies in the age of mass media: an Altmetrics-based analysis of Tissue Engineering. (Preprint)

10.2196/25394 ◽  
2020 ◽  
Author(s):  
Antonio Santisteban-Espejo ◽  
Miguel Angel Martin-Piedra ◽  
Antonio Campos ◽  
Julia Moran-Sanchez ◽  
Manuel Jesus Cobo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mass Media ◽  
Scientific Impact ◽  
Advanced Therapies

Information and scientific impact of Advanced Therapies in the age of mass media: an Altmetrics-based analysis of Tissue Engineering. (Preprint)

2020 ◽  
Author(s):  
Antonio Santisteban ◽  
Julia Moran ◽  
Miguel Ángel Martín Piedra ◽  
Antonio Campos Muñoz ◽  
José Antonio Moral Muñoz ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mass Media ◽  
Prediction Equation ◽  
Factorial Analysis ◽  
Online Media ◽  
Research Groups ◽  
Academic Institutions ◽  
Scientific Impact ◽  
Online Platforms ◽  
The Impact

BACKGROUND Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-staged organs. Its development has taken placed since the last decade of the 20th century, entailing a clinical revolution. In this sense, TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. OBJECTIVE To evaluate TE online dimension from 2012 to 2018 by using metadata obtained from the Web of Science (WoS) and Altmetrics and to develop a prediction equation for the impact of TE documents from Almetrics scores. METHODS We have analyzed 23,719 TE documents through descriptive and statistical methods. First, TE temporal evolution was exposed for WoS and fifteen online platforms (News, Blogs, Policy, Twitter, Patents, Peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, Video and Mendeley readers). The 10 most-cited TE original articles were ranked according to WoS citations and the Altmetric Attention Score. Second, in order to better comprehend TE online framework, a correlation and factorial analysis were performed based on the suitable results previously obtained for the Bartlett Sphericity and Kaiser-Meyer-Olkin tests. Finally, the liner regression model was applied to elucidate the relation between academy and online media and to construct a prediction equation for TE from Altmetrics data. RESULTS TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers and Altmetric Scores. However, WoS and Altmetrics rankings for the most cited documents clearly differs. When compared, the best correlation results were obtained for Mendeley readers and WoS (ρ=0.71). In addition, the factorial analysis identified six factors that could explain the previously observed differences between TE academy, and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than the 40% of TE WoS citations from Altmetrics scores. CONCLUSIONS The scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because of the focus of TE research importantly differs when the academic institutions and online platforms are compared, it could be stated that basic and clinical research groups, academic institutions and health politicians should take it into account in a coordinated effort oriented to the design and implementation of adequate strategies for information diffusion and population health education.

scholarly journals Advanced Therapies in Medicine and its diffusion in the online mass media: a bibliometric analysis of Tissue Engineering.

Authorea ◽  
2020 ◽  
Author(s):  
ANTONIO SANTISTEBAN ESPEJO ◽  
Miguel Martin Piedra ◽  
Antonio Campos Mu oz ◽  
Julia Mor n S nchez ◽  
Manuel Jes s Cobo Mart n ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mass Media ◽  
Bibliometric Analysis ◽  
Advanced Therapies

Information and scientific impact of Advanced Therapies in the age of mass media: an Altmetrics-based analysis of Tissue Engineering. (Preprint)

2020 ◽  
Author(s):  
Antonio Santisteban Espejo ◽  
Miguel Ángel Martín Piedra ◽  
Julia Morán Sánchez ◽  
José Antonio Moral Muñoz ◽  
Ana Isabel Pacheco Serrano ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mass Media ◽  
Prediction Equation ◽  
Factorial Analysis ◽  
Online Media ◽  
Research Groups ◽  
Academic Institutions ◽  
Scientific Impact ◽  
Online Platforms ◽  
The Impact

BACKGROUND Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-staged organs. Its development has taken placed since the last decade of the 20th century, entailing a clinical revolution. In this sense, TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. OBJECTIVE To evaluate TE online dimension from 2012 to 2018 by using metadata obtained from the Web of Science (WoS) and Altmetrics and to develop a prediction equation for the impact of TE documents from Almetrics scores. METHODS We have analyzed 23,719 TE documents through descriptive and statistical methods. First, TE temporal evolution was exposed for WoS and fifteen online platforms (News, Blogs, Policy, Twitter, Patents, Peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, Video and Mendeley readers). The 10 most-cited TE original articles were ranked according to WoS citations and the Altmetric Attention Score. Second, in order to better comprehend TE online framework, a correlation and factorial analysis were performed based on the suitable results previously obtained for the Bartlett Sphericity and Kaiser-Meyer-Olkin tests. Finally, the liner regression model was applied to elucidate the relation between academy and online media and to construct a prediction equation for TE from Altmetrics data. RESULTS TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers and Altmetric Scores. However, WoS and Altmetrics rankings for the most cited documents clearly differs. When compared, the best correlation results were obtained for Mendeley readers and WoS (ρ=0.71). In addition, the factorial analysis identified six factors that could explain the previously observed differences between TE academy, and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than the 40% of TE WoS citations from Altmetrics scores. CONCLUSIONS The scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because of the focus of TE research importantly differs when the academic institutions and online platforms are compared, it could be stated that basic and clinical research groups, academic institutions and health politicians should take it into account in a coordinated effort oriented to the design and implementation of adequate strategies for information diffusion and population health education.

scholarly journals Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration

2006 ◽  
Vol 4 (14) ◽  
pp. 413-437 ◽  
Author(s):  
Anthony D Metcalfe ◽  
Mark W.J Ferguson
Keyword(s):  
Tissue Engineering ◽  
Regenerative Process ◽  
Model Systems ◽  
Viral Gene ◽  
Skin Substitutes ◽  
Recent Advances ◽  
Advanced Therapies ◽  
Skin Replacement ◽  
Organ Repair ◽  
Complete Regeneration

Advanced therapies combating acute and chronic skin wounds are likely to be brought about using our knowledge of regenerative medicine coupled with appropriately tissue-engineered skin substitutes. At the present time, there are no models of an artificial skin that completely replicate normal uninjured skin. Natural biopolymers such as collagen and fibronectin have been investigated as potential sources of biomaterial to which cells can attach. The first generation of degradable polymers used in tissue engineering were adapted from other surgical uses and have drawbacks in terms of mechanical and degradation properties. This has led to the development of synthetic degradable gels primarily as a way to deliver cells and/or molecules in situ , the so-called smart matrix technology. Tissue or organ repair is usually accompanied by fibrotic reactions that result in the production of a scar. Certain mammalian tissues, however, have a capacity for complete regeneration without scarring; good examples include embryonic or foetal skin and the ear of the MRL/MpJ mouse. Investigations of these model systems reveal that in order to achieve such complete regeneration, the inflammatory response is altered such that the extent of fibrosis and scarring is diminished. From studies on the limited examples of mammalian regeneration, it may also be possible to exploit such models to further clarify the regenerative process. The challenge is to identify the factors and cytokines expressed during regeneration and incorporate them to create a smart matrix for use in a skin equivalent. Recent advances in the use of DNA microarray and proteomic technology are likely to aid the identification of such molecules. This, coupled with recent advances in non-viral gene delivery and stem cell technologies, may also contribute to novel approaches that would generate a skin replacement whose materials technology was based not only upon intelligent design, but also upon the molecules involved in the process of regeneration.

scholarly journals Biomaterials Development for Application in Tissue Engineering: Literature Review

2021 ◽  
Vol 4 (2) ◽  
pp. 76-80
Author(s):  
Taís dos Santos Costa
Keyword(s):  
Tissue Engineering ◽  
Literature Review ◽  
Bacterial Cellulose ◽  
Human Skin ◽  
Tissue Regeneration ◽  
Skin Diseases ◽  
Wide Applicability ◽  
Functional Systems ◽  
Advanced Therapies ◽  
Active Substances

The search for tissue regeneration has attracted a lot of attention due to its wide applicability, and great potential to solve several problems in advanced therapies. Currently, functional systems have been widely used as therapeutic solutions in the treatment of some skin diseases, whether chronic, acquired, or as a consequence of accidents and burns. It is possible due to the feasibility of releasing and/or acting in loco of some active substances with properties and characteristics very similar to human skin. In this sense, this work aimed to carry out a literature review research regarding the development of new biomaterials, including hydrated membranes composed of biopolymers such as keratin and bacterial cellulose.

Marine origin materials on biomaterials and advanced therapies to cartilage tissue engineering and regenerative medicine

2021 ◽  
Author(s):  
Duarte Nuno Carvalho ◽  
Rui Reis ◽  
T. H. Silva
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Cartilage Tissue Engineering ◽  
The Body ◽  
Cartilage Tissue ◽  
Repair Capacity ◽  
Marine Origin ◽  
The Past ◽  
Advanced Therapies

The body´s self-repair capacity is limited, including injuries on articular cartilage zones. Over the past few decades, tissue engineering and regenerative medicine (TERM) have focused the studies on the development...

scholarly journals Personalized Bone Reconstruction and Regeneration in the Treatment of Craniosynostosis

2021 ◽  
Vol 11 (6) ◽  
pp. 2649
Author(s):  
Federica Tiberio ◽  
Ilaria Cacciotti ◽  
Paolo Frassanito ◽  
Giuseppina Nocca ◽  
Gianpiero Tamburrini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Congenital Defects ◽  
Bone Fixation ◽  
Technological Advances ◽  
Biomimetic Scaffolds ◽  
Advanced Therapies ◽  
Skull Growth ◽  
Manufacturing Techniques ◽  
Resolving Functional

Craniosynostosis (CS) is the second most prevalent craniofacial congenital malformation due to the premature fusion of skull sutures. CS care requires surgical treatment of variable complexity, aimed at resolving functional and cosmetic defects resulting from the skull growth constrain. Despite significant innovation in the management of CS, morbidity and mortality still exist. Residual cranial defects represent a potential complication and needdedicated management to drive a targeted bone regeneration while modulating suture ossification. To this aim, existing techniques are rapidly evolving and include the implementation of novel biomaterials, 3D printing and additive manufacturing techniques, and advanced therapies based on tissue engineering. This review aims at providing an exhaustive and up-to-date overview of the strategies in use to correct these congenital defects, focusing on the technological advances in the fields of biomaterials and tissue engineering implemented in pediatric surgical skull reconstruction, i.e., biodegradable bone fixation systems, biomimetic scaffolds, drug delivery systems, and cell-based approaches.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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