scholarly journals Measuring adherence to tuberculosis medication in observational research: a DOT program for a prospective cohort study in Western Cape Province, South Africa (Preprint)

10.2196/24510 ◽  
2020 ◽  
Author(s):  
Elizabeth J. Ragan ◽  
Christopher J. Gill ◽  
Matthew Banos ◽  
Tara C. Bouton ◽  
Jennifer Rooney ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Observational Research ◽  
Western Cape ◽  
Western Cape Province

scholarly journals Measuring adherence to TB medication in observational research: a DOT program designed for a prospective cohort study (Preprint)

2020 ◽  
Author(s):  
Elizabeth J. Ragan ◽  
Christopher J. Gill ◽  
Matthew Banos ◽  
Tara C. Bouton ◽  
Jennifer Rooney ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Medication Adherence ◽  
Study Data ◽  
Observational Research ◽  
Western Cape ◽  
Directly Observed Therapy ◽  
Western Cape Province ◽  
Adherence Data ◽  
Program Function

UNSTRUCTURED A major challenge for prospective, clinical tuberculosis (TB) research is accurately defining a metric for measuring medication adherence. We present the design and methodology of a mobile health (mHealth)-based directly observed therapy (DOT) program developed for the purpose of measuring anti-TB medication adherence for a prospective TB cohort in Western Cape Province, South Africa. DOT workers collect daily adherence data on mobile smartphones. Both participant-level adherence as well as program-level adherence and program function are systematically and regularly monitored to assess implementation of the DOT program. A data dashboard allows for regular visualization of indicators. Numerous mechanisms were designed to prevent or limit data falsification and ensure study data integrity. This approach can be adapted in other settings to improve the capture of anti-TB medication adherence outside of a hospitalized setting.

scholarly journals Prospective cohort study of mortality in very low birthweight infants in a single centre in the Eastern Cape province, South Africa

2021 ◽  
Vol 5 (1) ◽  
pp. e000918
Author(s):  
Isabel A Michaelis ◽  
Ingeborg Krägeloh-Mann ◽  
Ncomeka Manyisane ◽  
Mikateko C Mazinu ◽  
Esme R Jordaan
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Birth Weight ◽  
Mortality Rate ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Low Birthweight ◽  
Eastern Cape Province ◽  
Eastern Cape ◽  
Overall Mortality

BackgroundNeonatal mortality is a major contributor worldwide to the number of deaths in children under 5 years of age. The primary objective of this study was to assess the overall mortality rate of babies with a birth weight equal or below 1500 g in a neonatal unit at a tertiary hospital in the Eastern Cape Province, South Africa. Furthermore, different maternal-related and infant-related factors for higher mortality were analysed.MethodsThis is a prospective cohort study which included infants admitted to the neonatal wards of the hospital within their first 24 hours of life and with a birth weight equal to or below 1500 g. Mothers who consented answered a questionnaire to identify factors for mortality.Results173 very low birth weight (VLBW) infants were recruited in the neonatal department between November 2017 and December 2018, of whom 55 died (overall mortality rate 32.0%). Twenty-three of the 44 infants (53,5%) with a birth weight below 1000 g died during the admission. One hundred and sixty-one mothers completed the questionnaire and 45 of their babies died.Main factors associated with mortality were lower gestational age and lower birth weight. Need for ventilator support and sepsis were associated with higher mortality, as were maternal factors such as HIV infection and age below 20 years.ConclusionThis prospective study looked at survival of VLBW babies in an underprivileged part of the Eastern Cape of South Africa. Compared with other public urban hospitals in the country, the survival rate remains unacceptably low. Further research is required to find the associated causes and appropriate ways to address these.

Effectiveness of the WHO/UNICEF guidelines on infant feeding for HIV-positive women: results from a prospective cohort study in South Africa

AIDS ◽  
2007 ◽  
Vol 21 (13) ◽  
pp. 1791-1797 ◽  
Author(s):  
Tanya Doherty ◽  
Mickey Chopra ◽  
Debra Jackson ◽  
Ameena Goga ◽  
Mark Colvin ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Infant Feeding ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hiv Positive ◽  
Hiv Positive Women

scholarly journals HIV incidence, pregnancy, and implementation outcomes from the Sakh'umndeni safer conception project in South Africa: a prospective cohort study

2019 ◽  
Vol 6 (7) ◽  
pp. e438-e446 ◽  
Author(s):  
Sheree R Schwartz ◽  
Jean Bassett ◽  
Lillian Mutunga ◽  
Nompumelelo Yende ◽  
Mutsa Mudavanhu ◽  
...  
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hiv Incidence ◽  
Safer Conception ◽  
Implementation Outcomes
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