scholarly journals Postprandial effects of macronutrient composition meals on metabolic responses and arterial stiffness indexes in lean and obese men adults; a protocol study (Preprint)

10.2196/21162 ◽  
2020 ◽  
Author(s):  
Naseh Pahlavani ◽  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Lida Jarahi ◽  
Mahsa Malekahmadi ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Metabolic Responses ◽  
Macronutrient Composition ◽  
Protocol Study

Postprandial effects of macronutrient composition meals on metabolic responses and arterial stiffness indexes in lean and obese men adults; a protocol study (Preprint)

2020 ◽  
Author(s):  
Naseh Pahlavani ◽  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Lida Jarahi ◽  
Mahsa Malekahmadi ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Study Protocol ◽  
Pulse Wave ◽  
Metabolic Response ◽  
Metabolic Responses ◽  
Medical Sciences ◽  
Three Phase ◽  
Component Pulse ◽  
Protocol Study ◽  
Meal Composition

BACKGROUND Background: Prior studies have shown that meal composition is capable of effect on metabolic response and arterial stiffness indexes. OBJECTIVE Objective: A three-phase parallel study will design to investigate the effects of meal composition on metabolic parameters and arterial stiffness indexes among lean and obese adult. The planned study protocol is presented METHODS Methods/design: This is a parallel clinical trial targeting adults (aged 18–35 years, free from any diseases) selected by inclusion and exclusion criteria at Mashhad University Medical Sciences. Each subject will complete three interventions with a washout period of one week: high carbohydrate, high protein and high fat meal. The postprandial effect will be assessed during 360 minutes from each meal including energy expenditure component, pulse wave analysis and pulse wave velocity and blood sampling. RESULTS N/A CONCLUSIONS Metabolic Responses, Macronutrients Composition, Arterial Stiffness, Study Protocol: The differences in postprandial response due to different meal composition could affect of metabolic and vascular parameters. This could provide necessary information for the establishment of new strategies in terms of nutritional education and metabolic and vascular improvement. CLINICALTRIAL Trial registration: Iranian Registry of Clinical Trials: IRCT20190818044552N1. Registered on August 26, 2019

scholarly journals Evaluation of the Acute Effects of Traditional Persian Medicine Based Hot and Cold Foods on Metabolic Responses and Arterial Stiffness in Healthy Men: Study Protocol for a Randomized Controlled Trial

2020 ◽  
Author(s):  
Mohsen Zakerian ◽  
Fatemeh Roudi ◽  
Reza Rezvani ◽  
Malihe Motavasselian
Keyword(s):  
Arterial Stiffness ◽  
Vascular Function ◽  
Vascular Reactivity ◽  
Controlled Trial ◽  
Main Tool ◽  
Metabolic Responses ◽  
Normal Body Mass Index ◽  
Healthy Men ◽  
Persian Medicine ◽  
Traditional Persian Medicine

Abstract Background: Traditional Persian Medicine (TPM)-based temperament is affected by some determinant factors that seems to have close similarities to resting energy expenditure (REE) and thermic effect of food (TEF) determinants. Pulse characteristics is considered as a main tool distinguishing different temperaments and vascular function and the probability of cardiovascular events are different in hot and cold-temper individuals in TPM point of view. Additionally, all foods are divided into cold/hot-temper and dry/wet-temper in this medical school and may lead to different responses in subjects regarding their temperaments.Methods: This experiment will be an acute phase study that will be performed on two groups of healthy individuals with normal body mass index (BMI) with hot and cold temperament. Each person will receive two TPM-based hot/cold isocaloric breakfast meals in 2 different days and metabolic responses and arterial stiffness indices thorough blood samples, indirect calorimetry, and pulse wave analysis and velocimetry will be assessed at fasting state, 0.5, 2, and 4 hours following meal consumption. Discussion: We will investigate the metabolic differences between individuals with TPM-based hot and cold temperaments and also to evaluate the effects of different TPM-based temperament of isocaloric meals (hot and cold) on metabolic responses and arterial stiffness indices in TPM-based hot/cold temper healthy men in this study. The results of this research project may lead to design of novel combined TPM and modern nutrition-based diet planning to improve metabolic responses and vascular reactivity. Trial registration: International Clinical Trials Registry Platform IRCT20200417047105N1, retrospectively registered at 19/04/2020. URL: https://irct.ir/trial/47267.

scholarly journals Postprandial Effects of Macronutrient Composition Meals on Metabolic Responses and Arterial Stiffness Indexes in Lean and Obese Men Adults; A Protocol Study

2020 ◽  
Author(s):  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Naseh Pahlavani ◽  
Lida Jarahi ◽  
Jamshid Gholizadeh Navashenaq ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Arterial Stiffness ◽  
Metabolic Response ◽  
Augmentation Index ◽  
Resting Energy Expenditure ◽  
Medical Sciences ◽  
Three Phase ◽  
Protocol Study ◽  
New Strategies ◽  
Meal Composition

Abstract Background: Prior studies have shown that meal composition is capable of effect on metabolic response and arterial stiffness indexes. Objective: A three-phase parallel study will be designed to investigate the effects of meal composition on metabolic parameters and arterial stiffness indexes among lean and obese adult. The planned study protocol will be presented.Methods/design: This is a pilot parallel clinical trial targeting adults (aged 18–35 years, free from any diseases) will be selected by inclusion and exclusion criteria at Mashhad University Medical Sciences. Each subject will complete three interventions with a washout period of one week: high carbohydrate, high protein and high fat meal. The postprandial effect will be assessed during 360 minutes from each meal including energy expenditure component (such as resting energy expenditure, thermic effect of feeding, respiratory quotient and substrate oxidation) and arterial stiffness indexes (such as augmentation index and pulse wave velocity) and blood sampling.Results: The study will be conducted from September 2020 to January 2021 (individual N=20). Assessment of intervention outcomes will be done in 6 hours after intervention.Conclusions: The differences in postprandial responses due to different meal composition could affect the metabolic and vascular parameters. This could provide necessary information for the establishment of new strategies in terms of nutritional education and metabolic and vascular improvement.Trial Registration: Iranian Registry of Clinical Trials: IRCT20190818044552N1. Registered on August 26, 2019

scholarly journals Postprandial effects of macronutrient composition meals on the metabolic responses and arterial stiffness indices of lean and obese male adults: a protocol of a pilot study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Naseh Pahlavani ◽  
Lida Jarahi ◽  
Jamshid Gholizadeh Navashenaq ◽  
...  
Keyword(s):  
Pilot Study ◽  
Energy Expenditure ◽  
Arterial Stiffness ◽  
Augmentation Index ◽  
Controlled Trial ◽  
Resting Energy Expenditure ◽  
Primary Objective ◽  
Metabolic Responses ◽  
Obese Adults ◽  
Meal Composition

Abstract Background Prior studies have shown that meal composition may affect the metabolic responses and arterial stiffness indices, and these responses may be different in lean and obese adults. The primary objective of this study is to determine the feasibility of conducting a trial to compare the effect of three test meals in lean and obese men. Due to the lack of a comprehensive study that concurrently compares metabolic responses and vascular stiffness indices after receiving three different meals in lean and obese men, this pilot study will be conducted with a three-phase parallel design, aiming to investigate the effects of meal composition on the metabolic parameters and arterial stiffness indices of lean and obese adults. Methods This pilot, a parallel clinical trial will be performed on 24 male adults aged 18–35 years since January 2021 and will continue until March 2021 who are disease-free and selected based on the inclusion and exclusion criteria at Mashhad University of Medical Sciences, Iran. The subjects will complete three interventions at a 1-week interval, including high carbohydrate (70% carbohydrates, 10% protein, 20% fat), high protein (30% protein, 50% carbohydrates, 20% fat), and high-fat meal (50% fat, 40% carbohydrates, 10% protein). Postprandial effects will be assessed within 360 min after each meal, including the energy expenditure component (resting energy expenditure, thermic effects of feeding, respiratory quotient, and substrate oxidation) and arterial stiffness indices (augmentation index and pulse wave velocity). In addition, blood sampling will be performed to measure glucose, insulin, free fatty acids, and lipid profile. Discussion The differences in the postprandial responses can affect the metabolic and vascular parameters due to different meal compositions, thereby providing beneficial data for the establishment of new strategies in terms of nutritional education and metabolic/vascular improvement. Also, the results from this pilot study will inform intervention refinement and efficacy testing of the intervention in a larger randomized controlled trial. Trial registration Iranian Registry of Clinical Trials; code: IRCT20190818044552N1; registered on August 26, 2019

scholarly journals Postprandial Effects of Macronutrient Composition Meals on the Metabolic Responses and Arterial Stiffness Indices of Lean and Obese Male Adults: A Protocol of pilot Study

2021 ◽  
Author(s):  
Safieh Firouzi ◽  
Reza Rezvani ◽  
Naseh Pahlavani ◽  
Lida Jarahi ◽  
Jamshid Gholizadeh Navashenaq ◽  
...  
Keyword(s):  
Pilot Study ◽  
Energy Expenditure ◽  
Arterial Stiffness ◽  
Augmentation Index ◽  
Resting Energy Expenditure ◽  
Metabolic Responses ◽  
Medical Sciences ◽  
Objective Prior ◽  
Three Phase ◽  
Meal Composition

Abstract Background & Objective: Prior studies have shown that meal composition may affect the metabolic responses and arterial stiffness indices. Due to the lack of a comprehensive study that concurrently compares metabolic responses and vascular stiffness indices after receiving three different meals in lean and obese men, this pilot study has been conducted with a three-phase parallel design, aiming to investigate the effects of meal composition on the metabolic parameters and arterial stiffness indices of lean and obese adults. Materials and Methods: This pilot, parallel clinical trial has been performed on 20 male adults aged 18-35 years who are disease-free and selected based on the inclusion and exclusion criteria at Mashhad University of Medical Sciences, Iran. The subjects have completed three interventions at a one-week interval, including high carbohydrate (70% carbohydrates, 10% protein, 20% fat), high protein (30% protein, 50% carbohydrates, 20% fat), and high fat meal (50% fat, 40% carbohydrates, 10% protein). Postprandial effects have been assessed within 360 minutes after each meal, including the energy expenditure component (resting energy expenditure, thermic effects of feeding, respiratory quotient, and substrate oxidation) and arterial stiffness indices (augmentation index and pulse wave velocity). In addition, blood sampling has been performed to measure glucose, insulin, free fatty acids, and lipid profile. Results: The study has started since September 2020 and will continue until January 2021. The assessment of the intervention outcomes will be carried out six hours after the end of the intervention. Conclusion: The differences in the postprandial responses c affect the metabolic and vascular parameters due to different meal compositions, thereby providing beneficial data for the establishment of new strategies in terms of nutritional education and metabolic/vascular improvement.

Arterial stiffness is a potential mechanism and promising indicator of orthostatic hypotension in the general population

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 423-432 ◽  
Author(s):  
Qingtao Meng ◽  
Si Wang ◽  
Yong Wang ◽  
Shixi Wan ◽  
Kai Liu ◽  
...  
Keyword(s):  
General Population ◽  
Arterial Stiffness ◽  
Orthostatic Hypotension ◽  
Operating Characteristic ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Multiple Logistic Regression Analysis ◽  
The Elderly ◽  
Baroreceptor Sensitivity ◽  
Roc Curve Analysis

Background: Orthostatic hypotension (OH) is a disease prevalent among middle-aged men and the elderly. The association between arterial stiffness and OH is unclear. This study evaluates whether arterial stiffness is correlated with OH and tests the usefulness of brachial-ankle pulse wave velocity (baPWV), an arterial stiffness marker, with regard to identifying OH. Patients and methods: A sample of 1,010 participants was recruited from the general population (64.8 ± 7.7 years; 426 men) who attended health check-ups. BaPWV and the radial augmentation index (rAI) were both assessed as the arterial stiffness markers, and OH was determined using blood pressure (BP) measured in the supine position, as well as 30 seconds and 2 minutes after standing. Results: The prevalence of OH in this population was 4.9 %. Compared with the non-OH group, both baPWV (20.5 ± 4.5 vs 17.3 ± 3.7, p < 0.001) and rAI (88.1 ± 10.8 vs 84.2 ± 10.7, p < 0.05) were significantly higher in the OH group. In the multiple logistic regression analysis, baPWV (OR, 1.3; 95 % CI, 1.106–1.528; p < 0.05) remained associated with OH. Moreover, the degree of orthostatic BP reduction was related to arterial stiffness. In addition, increases in arterial stiffness predicted decreases in the degree of heart rate (HR) elevation. Finally, a receiver operating characteristic (ROC) curve analysis showed that baPWV was useful in discriminating OH (AUC, 0.721; p < 0.001), with the cut-off value of 18.58 m/s (sensitivity, 0.714; specificity, 0.686). Conclusions: Arterial stiffness determined via baPWV, rather than rAI, was significantly correlated with the attenuation of the orthostatic hemodynamic response and the resultant OH. The impaired baroreceptor sensitivity might be the mechanism. In addition, baPWV appears to be a relatively sensitive and reliable indicator of OH in routine clinical practice.

Markers of arterial stiffness in peripheral arterial disease

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Marc Husmann ◽  
Vincenzo Jacomella ◽  
Christoph Thalhammer ◽  
Beatrice R. Amann-Vesti
Keyword(s):  
Arterial Stiffness ◽  
Peripheral Arterial Disease ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Arterial Disease ◽  
Care Physician ◽  
Additional Information ◽  
Non Invasive ◽  
Assessment Techniques ◽  
Peripheral Arterial

Abstract. Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

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