scholarly journals Immunobiological markers in prophylaxis post-exposure with single dose of rifampicin and BCG vaccine in contacts of multibacillary leprosy cases: study protocol. (Preprint)

10.2196/20968 ◽  
2020 ◽  
Author(s):  
Camila Massae Sato ◽  
Omar Ariel Espinosa Domínguez ◽  
Fabiane Verônica da Silva ◽  
Gutembergue Santos de Sousa ◽  
Roberta Olmo Pinheiro ◽  
...  
Keyword(s):  
Single Dose ◽  
Study Protocol ◽  
Bcg Vaccine ◽  
Post Exposure ◽  
Cases Study ◽  
Multibacillary Leprosy

Immunobiological Markers in Prophylaxis Post-exposure with Single Dose of Rifampicin and BCG Vaccine in Contacts of Multibacillary Leprosy Cases: Study Protocol (Preprint)

2020 ◽  
Author(s):  
Camila Massae Sato ◽  
Omar Ariel Espinosa Domínguez ◽  
Gutembergue Santos de Sousa ◽  
Fabiane Verônica da Silva ◽  
Roberta Olmo Pinheiro ◽  
...  
Keyword(s):  
Single Dose ◽  
Bcg Vaccine ◽  
Reference Laboratory ◽  
Serological Response ◽  
Bacillus Calmette Guerin ◽  
Prophylactic Measure ◽  
Mato Grosso ◽  
Household Contacts ◽  
Ifn Γ ◽  
Multibacillary Leprosy

BACKGROUND Leprosy contacts are sensitive indicator of the magnitude of severity, and a high risk for infection and disease, especially if the individuals are exposed to the bacillus with multibacillary cases, which reinforces the need for chemoprophylactic measures, such as the use single-dose rifampicin (SDR) combined with BCG vaccine. OBJECTIVE Our study will analyze the serological response of anti-NDO-LID, HO-1/HMOX and serum IFN-γ concentration as a prophylactic measure after the use of single-dose rifampicin (SDR) combined with the Bacillus Calmette-Guérin vaccine (BCG) among multibacillary leprosy household contacts. METHODS Intervention study based on a prospective cohort of household contacts of new cases of multibacillary leprosy diagnosed and registered in the Information System on Diseases of Compulsory Declaration (SINAN – Sistema de Informação de Agravos de Notificação) and residents in the municipalities of Cuiabá and Cáceres, Mato Grosso, in the years 2019 and 2020. Contacts with no signs and symptoms compatible with the disease of the intervention group will receive single-dose rifampicin (SDR) combined with BCG vaccine and will be compared to the control group. The follow-up of the cohort will last 12 months. The analyses of the anti-NDO-LID, HO-1/HMOX and serum concentration of IFN-γ tests as immunological markers before, 6 and 12 months after the intervention will be conducted in a reference laboratory (FIOCRUZ). RESULTS The study is still recruiting participants and is expected to be completed in September 2020. CONCLUSIONS Our study seeks to analyze the response of anti-NDO-LID, HO-1/HMOX tests and serum IFN-γ concentration as a prophylactic measure after the use of single-dose rifampicin (SDR) combined with the Bacillus Calmette-Guérin vaccine (BCG) in home contacts of multibacillary leprosy cases. CLINICALTRIAL Brazilian Registry of Clinical Trials (ReBEC), RBR-6yg2z9. Retrospectively registered on 3 de Out. de 2019.

scholarly journals Leprosy Post-Exposure Prophylaxis (LPEP) programme: study protocol for evaluating the feasibility and impact on case detection rates of contact tracing and single dose rifampicin

BMJ Open ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. e013633 ◽  
Author(s):  
Tanja Barth-Jaeggi ◽  
Peter Steinmann ◽  
Liesbeth Mieras ◽  
Wim van Brakel ◽  
Jan Hendrik Richardus ◽  
...  
Keyword(s):  
Single Dose ◽  
Study Protocol ◽  
Contact Tracing ◽  
Post Exposure Prophylaxis ◽  
Case Detection ◽  
Detection Rates ◽  
Post Exposure ◽  
Exposure Prophylaxis

scholarly journals Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Christoph M Rüegger ◽  
Christine Bartsch ◽  
Rosa Maria Martinez ◽  
Steffen Ross ◽  
Stephan A Bolliger ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Study Protocol ◽  
Virtual Autopsy ◽  
Conventional Autopsy ◽  
Cases Study

scholarly journals 1198. Lyme Disease Post-Exposure Prophylaxis by Single-Dose Doxycycline in Three Healthcare Systems

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S690-S690
Author(s):  
Grace E Marx ◽  
Anna M Schotthoefer ◽  
Brian S Schwartz ◽  
Evan Draper ◽  
Christina G Rivera ◽  
...  
Keyword(s):  
Single Dose ◽  
Lyme Disease ◽  
Disease Prevention ◽  
Healthcare Systems ◽  
Post Exposure Prophylaxis ◽  
Material Support ◽  
Post Exposure ◽  
Blacklegged Tick ◽  
High Incidence ◽  
Exposure Prophylaxis

Abstract Background Lyme disease, the most common tickborne disease in the United States, may be prevented by taking a single 200-mg dose of oral doxycycline after a high-risk bite from a blacklegged tick. Currently, it is not known how Lyme disease post-exposure prophylaxis (PEP) might vary by region and healthcare system. We identified single-dose doxycycline medication orders in three healthcare systems in states with high incidence of Lyme disease and compared associated patient and provider characteristics. Methods Electronic health record data during 2012 – 2016 were obtained from three healthcare systems: Geisinger (Pennsylvania), Marshfield Clinic (Wisconsin), and Mayo Clinic (Minnesota/Wisconsin). Creation of analytic variables and analysis were harmonized across the three sites. Medication orders for single-dose doxycycline ≤200 mg that were accompanied by specific key words or diagnostic codes (e.g., tick bite; Lyme disease prevention) were considered evidence of PEP. Manual chart review was performed from a random subset to evaluate the algorithms used to identify PEP. Results Among 2,937,585 patients with at least one medication order or clinical encounter during the study period, 14,102 single-dose doxycycline orders for Lyme disease PEP for 13,172 unique patients were identified. The typical patient receiving PEP was older (mean age 51 – 58 years), male (56 – 59%), and non-Hispanic White (81 – 98%). The annual seasonality of medication orders was bimodal, with peaks occurring during April – July and October – November. The most common encounter setting was an outpatient clinic or urgent care center (80 – 91%); medication orders after patient phone calls in the absence of an in-person visit occurred frequently (14 – 19%) in two health systems. Chart abstractions (n=600) revealed instances of PEP prescribed inappropriately (e.g., bite from a non-blacklegged tick; patient with symptoms of acute Lyme disease). Conclusion Lyme disease PEP with a single dose of doxycycline was frequently prescribed in healthcare systems where there is a high incidence of Lyme disease. PEP was most commonly prescribed to non-Hispanic Whites over the age of 50 years. Public health initiatives for tickborne disease prevention should include clinician education on the appropriate use of Lyme disease PEP. Disclosures Anna M. Schotthoefer, PhD, HelixBind (Other Financial or Material Support, salary support) John Zeuli, PharmD, INSMED (Other Financial or Material Support, honoraria for educational speaking)

scholarly journals Effectiveness Analysis of Single Dose Rifampicin-Post-Exposure Prophylaxis (SDR-PEP) as A Preventive Intervention for Leprosy Transmission: A Systematic Review of Randomized Controlled Trials

2021 ◽  
Vol 4 (2) ◽  
pp. 35-43
Author(s):  
Muhammad Mikail Athif Zhafir Asyura ◽  
Ilma Ranjani Wijaya ◽  
Theetouch Toshukowong ◽  
Rui Sheng Wang
Keyword(s):  
Systematic Review ◽  
Single Dose ◽  
Randomized Controlled Trials ◽  
Large Scale ◽  
Preventive Intervention ◽  
Post Exposure Prophylaxis ◽  
Controlled Trials ◽  
Post Exposure ◽  
Randomized Controlled ◽  
Exposure Prophylaxis

Introduction: Leprosy is a skin disease that reaches 200,000 cases annually. Considered a neglected tropical disease, 80% of annual leprosy remained in countries such as Brazil, India, and Indonesia. Multi-drug treatment is effective in curing leprosy but ineffective in preventing further transmission. The implementation of large-scale single dose rifampicin-post exposure prophylaxis suggests the inhibition of leprosy transmission and thus needs validation.Methods: This systematic review was carried out based on the PRISMA statement from multiple databases using set keywords. A total of 646 studies were identified, followed by 4 randomized controlled trials included after screening.Results: 86,502 subjects were divided into control and interventional groups and were to be followed up in 2-6 years. Most studies showed a significant decrease of leprosy cases by 50-60%. Furthermore, a complementary effect between single-dose rifampicin-post exposure prophylaxis and Bacillus Calmette–Guérin vaccine was identified. Moreover, the cost-effectiveness of the intervention was analyzed which resulted in IDR 80,414,775 being averted in its 25th year of implementationConclusion: The review established promising results of implementing single dose rifampicin-post exposure prophylaxis to prevent leprosy transmission. Further national scale intervention with a multi-layered approach is suggested to ensure full support and continuity of the large-scale intervention 

scholarly journals Leprosy post-exposure prophylaxis with single-dose rifampicin (LPEP): an international feasibility programme

2021 ◽  
Vol 9 (1) ◽  
pp. e81-e90 ◽  
Author(s):  
Jan Hendrik Richardus ◽  
Anuj Tiwari ◽  
Tanja Barth-Jaeggi ◽  
Mohammad A Arif ◽  
Nand Lal Banstola ◽  
...  
Keyword(s):  
Single Dose ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Exposure Prophylaxis

scholarly journals Single dose versus 24 h antibiotic prophylaxis in reduction mammaplasty: study protocol for a randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Daniela Francescato Veiga ◽  
Edgard da Silva Garcia ◽  
José Wilson Moreira-Filho ◽  
Evelyne Borges de Mattos Andrade ◽  
Yara Juliano ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Single Dose ◽  
Antibiotic Prophylaxis ◽  
Study Protocol ◽  
Reduction Mammaplasty ◽  
Controlled Trial ◽  
Randomized Controlled
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