scholarly journals Application of Computed Tomography Angiography Data Monitoring in Cerebral Glioma (Preprint)

10.2196/19078 ◽  
2020 ◽  
Author(s):  
Yongmei Yu ◽  
Zhaofeng Du ◽  
Changxin Yuan ◽  
Jian Li ◽  
Bern Ardlee
2020 ◽  
Author(s):  
Yongmei Yu ◽  
Zhaofeng Du ◽  
Changxin Yuan ◽  
Jian Li ◽  
Bern Ardlee

BACKGROUND Background: Glioma are tumors derived from neuroectodermal stromal cells and one of the most common malignant tumors of the brain. OBJECTIVE Objective:The objective is to understand the application of CT angiography in the proliferation of glioma cells more clearly and get more effective diagnosis and treatment of glioma. METHODS Methods: The adult male healthy Sprague Dawley (SD) rats were selected as the research objects to construct the animal models. In addition, respective on the 7th day, 14th day, and the 21st day, the rats were submitted to CT scans. According to parameters and indicators such as cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP), the stained cerebral tissues of rats at different time nodes were further analyzed. RESULTS Results: The results of rat CT manifestation analysis and clinical analysis showed that with the time increased, the volume of the tumors in rats increased apparently, with symptoms such as listlessness appeared at the initial stage and hemiplegia appeared at the later stage. The comparative analysis results of CT parameters at different times nodes showed that in the same tumor area, before the 14th day, CBF, CBV, and TTP showed the increasing trends, which gradually decreased after the 14th day, with significant statistical difference (P<0.01). However, MTT showed a decreasing trend in general, which is not apparent. The results of Vascular endothelial growth factor (VEGF) staining of the tumor area, the peritumoral area, and the contralateral mirror area at different time nodes showed that the vascular endothelial cells, the smooth muscle cells of vessel walls, and the tumor cells were strongly positive. In addition, with the time increased, in the tumor area, the peripheral area, and the contralateral mirror area, the cells increased in both volume and quantity, showing significant differences. CONCLUSIONS Conclusion: Therefore, through the research in this study, it is found that the computed tomography angiography data monitoring can reflect the angiogenesis of rat cerebral glioma. CLINICALTRIAL


VASA ◽  
2012 ◽  
Vol 41 (2) ◽  
pp. 132-135 ◽  
Author(s):  
Krohn ◽  
Gebauer ◽  
Hübler ◽  
Beck

The mid-aortic syndrome is an uncommon clinical condition characterized by severe narrowing of the descending aorta, usually with involvement of its renal and visceral branches, presenting with uncontrollably elevated blood pressures of the upper body, renal and cardiac failure, intestinal ischemia, encephalopathy symptoms and claudication of the lower limbs, although clinical presentation is variable. In this article we report the case of an eleven-year-old patient with the initial diagnosis of a mid-aortic syndrome and present the computed tomography angiography pictures and reconstructions before and after surgical therapy.


2020 ◽  
Vol 6 (2) ◽  
pp. 78-81
Author(s):  
Md Tauhidul Islam Chowdhury ◽  
Mohammad Shah Jahirul Hoque Chowdhury ◽  
Mohammad Sadekur Rahman Sarkar ◽  
KM Ahasan Ahmed ◽  
Md Nazmul Kabir ◽  
...  

Background: In evaluation of non-traumatic subarachnoid hemorrhage CT angiography (CTA) has 97-98% sensitivity and near 100% specificity. Objective: This study was conducted to evaluate the CTA findings of CT positive non traumatic subarachnoid hemorrhage. Methodology: This is an observational cross sectional study performed in Neurology department of National Institute of Neurosciences and Hospital, Dhaka over one year period (January 2019 to December 2019). Total 87 CT positive subarachnoid hemorrhage cases were purposively included in this study. All CT positive patients underwent CTA of Cerebral vessels for further evaluation. The angiography were evaluated by competent neuro-radiologists blinded about the study. Result: Among 87 patients, 40.2% were male and 59.8% were female. The average age was 53.33±11.1 years. Among the studied patient the source of bleeding was found 78.16% aneurysmal and 21.84% non-aneurysmal. 85.30% patients had single aneurysm and 14.70% had multiple aneurysm. The highest number of patient had Acom aneurysm (41.17%) followed by MCA (22.05%), ICA (13.23%), ACA (7.35%) and vertebral artery (1.14%) in order of frequency. Among the multiple aneurysm group most of the patients had combination of Acom, MCA and ICA aneurysm. Conclusion: From this study, we can conclude that CTA can be used as the primary diagnostic tool in evaluation of spontaneous SAH. Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 78-81


2011 ◽  
Vol 12 (1) ◽  
pp. 62-63 ◽  
Author(s):  
Thomas Henzler ◽  
Steffen Diehl ◽  
Susanne Jochum ◽  
Tim Sueselbeck ◽  
Stefan O Schoenberg ◽  
...  

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