scholarly journals Title: Risk factors and prevalence of dilated cardiomyopathy in Sub Saharan Africa: protocol for a systematic review article (Preprint)

10.2196/18229 ◽  
2020 ◽  
Author(s):  
Lulu Said Fundikira ◽  
Pilly Chillo ◽  
Linda Van Laake ◽  
Reuben Kato Mutagaywa ◽  
Amand Floriaan Schmidt ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Dilated Cardiomyopathy ◽  
Review Article ◽  
Sub Saharan Africa ◽  
Sub Saharan

scholarly journals Predictors of lost to follow up from antiretroviral therapy among adults in sub-Saharan Africa: a systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Hafte Kahsay Kebede ◽  
Lillian Mwanri ◽  
Paul Ward ◽  
Hailay Abrha Gesesew
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
Hiv Care ◽  
Care Services ◽  
Validity Assessment ◽  
Sub Saharan ◽  
Lost To Follow Up

Abstract Background It is known that ‘drop out’ from human immunodeficiency virus (HIV) treatment, the so called lost-to-follow-up (LTFU) occurs to persons enrolled in HIV care services. However, in sub-Saharan Africa (SSA), the risk factors for the LTFU are not well understood. Methods We performed a systematic review and meta-analysis of risk factors for LTFU among adults living with HIV in SSA. A systematic search of literature using identified keywords and index terms was conducted across five databases: MEDLINE, PubMed, CINAHL, Scopus, and Web of Science. We included quantitative studies published in English from 2002 to 2019. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used for methodological validity assessment and data extraction. Mantel Haenszel method using Revman-5 software was used for meta-analysis. We demonstrated the meta-analytic measure of association using pooled odds ratio (OR), 95% confidence interval (CI) and heterogeneity using I2 tests. Results Thirty studies met the search criteria and were included in the meta-analysis. Predictors of LTFU were: demographic factors including being: (i) a male (OR = 1.2, 95% CI 1.1–1.3, I2 = 59%), (ii) between 15 and 35 years old (OR = 1.3, 95% CI 1.1–1.3, I2 = 0%), (iii) unmarried (OR = 1.2, 95% CI 1.2–1.3, I2 = 21%), (iv) a rural dweller (OR = 2.01, 95% CI 1.5–2.7, I2 = 40%), (v) unemployed (OR = 1.2, 95% CI 1.04–1.4, I2 = 58%); (vi) diagnosed with behavioral factors including illegal drug use(OR = 13.5, 95% CI 7.2–25.5, I2 = 60%), alcohol drinking (OR = 2.9, 95% CI 1.9–4.4, I2 = 39%), and tobacco smoking (OR = 2.6, 95% CI 1.6–4.3, I2 = 74%); and clinical diagnosis of mental illness (OR = 3.4, 95% CI 2.2–5.2, I2 = 1%), bed ridden or ambulatory functional status (OR = 2.2, 95% CI 1.5–3.1, I2 = 74%), low CD4 count in the last visit (OR = 1.4, 95% CI 1.1–1.9, I2 = 75%), tuberculosis co-infection (OR = 1.2, 95% CI 1.02–1.4, I2 = 66%) and a history of opportunistic infections (OR = 2.5, 95% CI 1.7–2.8, I2 = 75%). Conclusions The current review identifies demographic, behavioral and clinical factors to be determinants of LTFU. We recommend strengthening of HIV care services in SSA targeting the aforementioned group of patients. Trial registration Protocol: the PROSPERO Registration Number is CRD42018114418

Intimate Partner Violence (IPV) Against HIV-Positive Women in Sub-Saharan Africa: A Mixed-Method Systematic Review and Meta-Analysis

2020 ◽  
pp. 152483802090656 ◽  
Author(s):  
Eric Y. Tenkorang ◽  
Michael Asamoah-Boaheng ◽  
Adobea Y. Owusu
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Intimate Partner Violence ◽  
Partner Violence ◽  
Meta Analysis ◽  
Intimate Partner ◽  
Sub Saharan Africa ◽  
Hiv Positive ◽  
Hiv Positive Women ◽  
Sub Saharan

Objectives: To systematically analyze and summarize the literature on intimate partner violence (IPV) against HIV-positive women in sub-Saharan Africa (SSA) and to identify their risk factors for IPV. Method: A comprehensive review of the literature using the Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analyses of Observational Studies in Epidemiology (MOOSE) yielded 1,879 articles (PubMed = 1,251, Embase = 491, Web of Science = 132, and identified additional records = 5). Twenty were selected for quantitative and qualitative assessment and synthesis. We employed a random effects model with generic inverse variance method and estimated the odds ratios. Findings: Results indicated a high prevalence of physical, sexual, and emotional violence against women living with HIV/AIDS in SSA. Educational background, alcohol use, marital status, previous experiences with IPV, and employment status were identified as significant risk factors. We also assessed the methodological quality of the articles by examining publication bias and some heterogeneity statistics. Conclusion: There is limited research on IPV against HIV-positive women in SSA. However, the few existing studies agree on the importance of targeting HIV-positive women with specific interventions given their vulnerability to IPV and to address factors exacerbating these risks and vulnerabilities.

scholarly journals Risk factors and prevalence of dilated cardiomyopathy in Sub Sahara Africa: a systematic review article (Preprint)

2020 ◽  
Author(s):  
Linda Van Laake ◽  
Lulu Said Fundikira ◽  
Pilly Chillo ◽  
David G Paulo ◽  
Reuben Kato Mutagaywa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Preventive Measures ◽  
Hypertensive Heart Disease ◽  
Left Ventricular ◽  
Sub Saharan Africa ◽  
Inclusion Criteria ◽  
Reference Manager ◽  
Sub Saharan

BACKGROUND Cardiomyopathies, defined as diseases involving mainly the heart muscle, are linked to 5.9 of 100,000 of estimated mortality of the global population although underdiagnosis is significant. In sub Saharan Africa, studies show that cardiomyopathy constitutes 21.4% of cases with heart failure and comes second only to hypertensive heart disease. However, there is paucity of data in the region regarding the different types of cardiomyopathies. It has been noted that presence of non-modifiable cardiovascular risk factors such as family history, age, ethnicity, gender as well as modifiable risk factors such as hypertension, diabetes, tobacco use, physical inactivity, poor nutrition, excessive alcohol consumption, high cholesterol and obesity increase the probability of developing cardiovascular disease. OBJECTIVE The review will focus on available literature in sub- Saharan Africa on prevalence of dilated cardiomyopathy (DCM) and associated risk factors in patients with DCM. It will identify gaps in knowledge regarding DCM and establish a foundation for preventive measures through reduction of the risk factors. This will be the first review that focuses solely on DCM while updating available data from previous reviews on cardiomyopathies in sub Saharan Africa. METHODS The review will consider all studies, qualitative and quantitative, which involve patients with a diagnosis of dilated cardiomyopathy as well as risk factors encountered in such patients in sub Saharan Africa. Both hospital based and community based studies will be included. Indexed articles in Medline and Embase will be searched. Full copies of articles identified by the search, and considered to meet the inclusion criteria, based on their title, abstract and subject descriptors, will be obtained for data synthesis. Bibliographic searches will also be considered for data collection based on their titles. The collected data will be organized in Mendeley reference manager and later on uploaded to Rayyan web application for systematic reviews articles to allow adequate sorting. Two reviewers will independently select articles against the inclusion criteria. Discrepancies in reviewer selections will be resolved by a third author (arbitrator) prior to selected articles being retrieved. RESULTS Interventions to be documented will include those related to screening and control of risk factors that may lead to DCM, and presence of assessment strategies in patients suspected with DCM. The primary outcome will be the number of cases with different etiologies of DCM. Secondary outcomes will be the number of hospitalizations, mortality due to heart failure, incidence of sudden cardiac death, proportion of participants on heart failure medications, proportion of participants with implantable cardioverter defibrillator placements, number of cases with left ventricular assist device and number of heart transplants in patients with DCM. CONCLUSIONS The review will give an update on the status of DCM in sub Sahara Africa and identify gaps that need to be addressed in order to improve preventive measures as well as management of this condition.

scholarly journals A systematic review of risk factors for neonatal mortality in Adolescent Mother’s in Sub Saharan Africa

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Astha Ramaiya ◽  
Ligia Kiss ◽  
Paula Baraitser ◽  
Godfrey Mbaruku ◽  
Zoe Hildon
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Neonatal Mortality ◽  
Sub Saharan Africa ◽  
Sub Saharan

scholarly journals Prevalence, incidence and risk factors for anogenital warts in Sub Saharan Africa: a systematic review and meta analysis

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Cecily Banura ◽  
Florence M Mirembe ◽  
Jackson Orem ◽  
Anthony K Mbonye ◽  
Simon Kasasa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
Anogenital Warts ◽  
Sub Saharan

Neonatal Septicaemia in Sub-Saharan Africa: A Protocol for Systematic Review and Meta-analysis.

2020 ◽  
Author(s):  
Micheal Abel Alao ◽  
Oluwakemi O Tongo ◽  
Idowu Adejumoke Ayede ◽  
Michael Udochukwu Diala ◽  
Olayinka Rasheed Ibrahim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Hospital Mortality ◽  
Observational Studies ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Sub Saharan Africa ◽  
Bacterial Isolates ◽  
Neonatal Septicaemia ◽  
Sub Saharan

Abstract Background: The morbidity and mortality from neonatal septicaemia (NNS) in low-middle income country remain high at the background of strained health care delivery system.The burden, pooled risks and outcomes of NNS are largely unknown. We aimed to produce a protocol for synthesizing evidence from available data for neonatal septicaemia in sub-Saharan Africa.Methods: We developed a search strategy using MeSH, text words and entry terms. Nine databases will be searched: PubMed, Embase, CINAHL, AJOL, Google Scholar, Web of Science, Cochrane Library, Research gate and Scopus. Only Observational studies retrievable in the English Language will be included. The primary measurable outcome is the proportion of neonatal with septicaemia while secondary outcomes include proportion of bacterial isolates and their antibiogram, risk factors for NNS, in hospital mortality, length of hospital stay, frequency of necrotizing enterocolitis and other sequel . All identified studies will be screened based on the inclusion criteria. Data will be deduplicated in Endnote version 9, before exporting to Rayyan QCRI for screening. Extractable data will include first author’s name and year of publication, the country and regions in sub-Saharan Africa, total neonatal admissions, number with sepsis, the sample size, bacterial isolates, antibiogram, in-hospital mortality, length of hospital stay and frequency of necrotizing enterocolitis.All studies will be assessed for methodological, clinical and statistical heterogeneity. The NIH Quality assessment tool for observational studies and the Cochrane tool of risk of bias will be used to assess for the strength of evidence. Publication bias will be assessed using the funnel plot.Discussion: Results will be presented as the prevalence, standard error and confidence interval of newborns with neonatal septicaemia in sub-Saharan Africa. Subgroup analysis using categorical data such as risk factors, bacterial isolates, antibiogram and outcomes of neonatal septicaemia will also be reported. A cumulative meta-analysis will be done to assess the time trend of the risk factors, pathogens and antibiogram.The CMA version 3 will be used for statistical analysis. Results will be presented in forest plots.Systematic Review Registration: This protocol is registered in PROSPERO, registration number CRD42020219604.

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