scholarly journals Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial

10.2196/11911 ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. e11911 ◽  
Author(s):  
Christian Kromer ◽  
Viktoria P Nühnen ◽  
Wolfgang Pfützner ◽  
Sebastian Pfeiffer ◽  
Hans-Joachim Laubach ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Atopic Dermatitis ◽  
Blue Light ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Full Body

scholarly journals Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial (Preprint)

2018 ◽  
Author(s):  
Christian Kromer ◽  
Viktoria P Nühnen ◽  
Wolfgang Pfützner ◽  
Sebastian Pfeiffer ◽  
Hans-Joachim Laubach ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Atopic Dermatitis ◽  
Blue Light ◽  
Skin Diseases ◽  
Controlled Trial ◽  
Ethics Committee ◽  
Inflammatory Skin Diseases ◽  
Randomized Controlled ◽  
The University ◽  
Full Body

BACKGROUND Irradiation with visible blue light (wavelength 400-495 nm) is a promising, effective, and safe new treatment option for chronic inflammatory skin diseases such as psoriasis and atopic dermatitis. OBJECTIVE We will perform a multicenter, placebo-controlled, double-blinded, 3-armed, prospective, randomized controlled trial to investigate the efficacy and safety of full-body blue light devices (wavelengths: 415 nm and 450 nm) compared with that of placebo irradiation for the treatment of atopic dermatitis. METHODS We are planning to enroll a total of 150 patients at the University hospitals in Göttingen (Germany), Marburg (Germany), and Geneva (Switzerland). RESULTS The trial was approved by the lead ethics committee of the medical faculty of the University of Göttingen (21/11/16). Further approvals were obtained from local and federal authorities (ethics committee Marburg, Cantonal Commission for Research Ethics Geneva, Suisse Medic, and Bundesinstitut für Arzneimittel und Medizinprodukte). CONCLUSIONS We will disseminate the results in a peer-reviewed journal. CLINICALTRIAL ClinicalTrials.gov NCT03085303; https://clinicaltrials.gov/ct2/show/NCT03085303 (Archived by WebCite at http://www.webcitation.org/73ucqkkA1) INTERNATIONAL REGISTERED REPOR PRR1-10.2196/11911

scholarly journals LD-Aminopterin in the Canine Homologue of Human Atopic Dermatitis: A Randomized, Controlled Trial Reveals Dosing Factors Affecting Optimal Therapy

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108303 ◽  
Author(s):  
John A. Zebala ◽  
Alan Mundell ◽  
Linda Messinger ◽  
Craig E. Griffin ◽  
Aaron D. Schuler ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Atopic Dermatitis ◽  
Controlled Trial ◽  
Factors Affecting ◽  
Randomized Controlled ◽  
Optimal Therapy

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis

2010 ◽  
Vol 22 (3) ◽  
pp. 144-150 ◽  
Author(s):  
Mohammad Hassan Javanbakht ◽  
Seyed Ali Keshavarz ◽  
Mahmoud Djalali ◽  
Fereydoun Siassi ◽  
Mohammad Reza Eshraghian ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Atopic Dermatitis ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals SCIPA Full-On: A Randomized Controlled Trial Comparing Intensive Whole-Body Exercise and Upper Body Exercise After Spinal Cord Injury

2018 ◽  
Vol 32 (6-7) ◽  
pp. 557-567 ◽  
Author(s):  
Mary P. Galea ◽  
Sarah A. Dunlop ◽  
Timothy Geraghty ◽  
Glen M. Davis ◽  
Andrew Nunn ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Randomized Controlled Trial ◽  
Adverse Events ◽  
Controlled Trial ◽  
Upper Body ◽  
Whole Body ◽  
Upper Body Exercise ◽  
Randomized Controlled ◽  
Cord Injury ◽  
Full Body

Background. While upper body training has been effective for improving aerobic fitness and muscle strength after spinal cord injury (SCI), activity-based therapies intended to activate the paralyzed extremities have been reported to promote neurological improvement. Objective. To compare the effectiveness of intensive whole-body exercise compared with upper body exercise for people with chronic SCI. Methods. A parallel-group randomized controlled trial was conducted. Participants with a range of SCI levels and severity were randomized to either full-body exercise (FBE) or upper body exercise (UBE) groups (3 sessions per week over 12 weeks). FBE participants underwent locomotor training, functional electrical stimulation-assisted leg cycling, and trunk and lower extremity exercises, while UBE participants undertook upper body strength and aerobic fitness training only. The primary outcome measure was the American Spinal Injury Association (ASIA) motor score for upper and lower extremities. Adverse events were systematically recorded. Results. A total of 116 participants were enrolled and included in the primary analysis. The adjusted mean between-group difference was −0.04 (95% CI −1.12 to 1.04) for upper extremity motor scores, and 0.90 (95% CI −0.48 to 2.27) for lower extremity motor scores. There were 15 serious adverse events in UBE and 16 in FBE, but only one of these was definitely related to the experimental intervention (bilateral femoral condyle and tibial plateau subchondral fractures). No significant between-group difference was found for adverse events, or functional or behavioral variables. Conclusions. Full-body training did not lead to improved ASIA motor scores compared with upper body training in people with chronic SCI.

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