scholarly journals Smartphone-Based Contingency Management Intervention to Improve Pre-Exposure Prophylaxis Adherence: Pilot Trial

10.2196/10456 ◽  
2018 ◽  
Vol 6 (9) ◽  
pp. e10456 ◽  
Author(s):  
John T Mitchell ◽  
Sara LeGrand ◽  
Lisa B Hightow-Weidman ◽  
Mehri S McKellar ◽  
Angela DM Kashuba ◽  
...  
Keyword(s):  
Contingency Management ◽  
Pilot Trial ◽  
Management Intervention ◽  
Exposure Prophylaxis

scholarly journals Smartphone-Based Contingency Management Intervention to Improve Pre-Exposure Prophylaxis Adherence: Pilot Trial (Preprint)

2018 ◽  
Author(s):  
John T Mitchell ◽  
Sara LeGrand ◽  
Lisa B Hightow-Weidman ◽  
Mehri S. McKellar ◽  
Angela DM Kashuba ◽  
...  
Keyword(s):  
Contingency Management ◽  
Community Sample ◽  
Pilot Trial ◽  
Behavioral Strategies ◽  
Open Label ◽  
Management Intervention ◽  
Adherence Assessment ◽  
Highly Correlated ◽  
Willingness To Recommend ◽  
Exposure Prophylaxis

BACKGROUND Pre-exposure prophylaxis (PrEP) provides a strong preventative benefit to individuals at risk for HIV. While PrEP adherence is highly correlated with its efficacy, adherence rates are variable both across and within persons. OBJECTIVE The objective of this study was to develop and pilot-test a smartphone-based intervention, known as mSMART, that targets PrEP adherence. mSMART provides contingency management in the form of monetary incentives for daily PrEP adherence based on a real-time adherence assessment using a camera-based medication event-monitoring tool as well as medication reminders, PrEP education, individualized behavioral strategies to address PrEP adherence barriers, and medication adherence feedback. METHODS This was a 4-week open-label, phase I trial in a community sample of young men who have sex with men already on PrEP (N=10). RESULTS Although adherence composite scores corresponding to PrEP biomarkers indicated that 90% (9/10) of the sample already had an acceptable baseline adherence in the protective range, by the end of the 4-week period, the scores improved for 30% (3/10) of the sample—adherence did not worsen for any participants. Participants reported mean PrEP adherence rates of 91% via daily entries in mSMART. At the end of the 4-week period, participants indicated acceptable ratings of satisfaction, usability, and willingness to recommend mSMART to others. There were no technical difficulties associated with smartphone compatibility, user misunderstandings about mSMART features that interfered with daily use, or study attrition. CONCLUSIONS This study is the first to apply contingency management to PrEP adherence. Findings indicated that mSMART is feasible and acceptable. Such an adherence intervention administered via a user-friendly smartphone app can allow for widespread dissemination. Future efficacy trials are needed. CLINICALTRIAL ClinicalTrials.gov NCT02895893; https://clinicaltrials.gov/ct2/show/NCT02895893 (Accessed by Webcite at http://www.webcitation.org/72JskjDJq)

scholarly journals Pretreatment ethyl glucuronide levels predict response to a contingency management intervention for alcohol use disorders among adults with serious mental illness

2017 ◽  
Vol 26 (7) ◽  
pp. 673-675 ◽  
Author(s):  
Michael Gerard McDonell ◽  
Emily Leickly ◽  
Sterling McPherson ◽  
Jordan Skalisky ◽  
Katherine Hirchak ◽  
...  
Keyword(s):  
Mental Illness ◽  
Alcohol Use ◽  
Serious Mental Illness ◽  
Contingency Management ◽  
Alcohol Use Disorders ◽  
Ethyl Glucuronide ◽  
Management Intervention

scholarly journals Pre-exposure prophylaxis adherence with real-time adherence feedback and partner HIV self-testing: A pilot trial among postpartum women

2021 ◽  
Author(s):  
Dvora L Joseph Davey ◽  
Kathryn Dovel ◽  
Rufaro Mvududu ◽  
Dorothy Nyemba ◽  
Nyiko Mashele ◽  
...  
Keyword(s):  
Pilot Study ◽  
Real Time ◽  
Pilot Trial ◽  
Intervention Group ◽  
Standard Of Care ◽  
Postpartum Women ◽  
Care Clinic ◽  
The Past ◽  
Self Testing ◽  
Exposure Prophylaxis

Background: Pre-exposure prophylaxis (PrEP) is safe and effective in postpartum women. HIV self-testing (HIVST) for partners combined with biofeedback counselling through real-time adherence measures may improve daily PrEP use among postpartum women. Methods: Between August 2020 and April 2021 we conducted a pilot study in one primary care clinic in Cape Town, South Africa. We randomized postpartum women who initiated PrEP in pregnancy 1:1 to the intervention group (HIVST + biofeedback counselling following urine tenofovir test) or to standard of care (facility-based HIV tests and routine counselling without biofeedback). The outcomes of interest were PrEP adherence in the past 48-72hours via urine tenofovir tests and partner HIV testing, measured 1-month after randomisation. Secondary outcomes included proportion of partners who tested for HIV and discrepancy between self-reported PrEP adherence and urine tenofovir result. Results: We enrolled 106 women (median age=26 years; median months postpartum=2). Almost half of women reported having sex since giving birth (48%); 76% of those reported condomless sex at last sex. At enrolment most women (72%) reported missing <2 doses in the past 7-days; 36% of women had tenofovir present in her urine (no significant differences by arm). One month after enrolment, 62% (n=33) of women in the intervention arm had tenofovir present in their urine compared to 34% (n=18) in the standard of care arm (RR=1.83; 95% CI=1.19, 2.82). Two-thirds of women in the intervention arm reported that her partner tested for HIV (66%; n=35); compared to 17% (n=9) in the standard of care arm (RR=3.89; 95% CI=2.08, 7.27). The proportion of women with a discrepant adherence result (self-reported good recent adherence with no tenofovir in urine test) was significantly lower in the intervention group (n=8; 17%) compared to the standard of care group (n=24; 46%) (RR=0.33; 95% CI=0.17, 0.67). No social or clinical adverse events were reported in the intervention arm. Conclusions: In this pilot study, HIVST for partners and biofeedback counseling increased levels of recent PrEP adherence, pointing to the importance of these interventions to support PrEP use in this population.

scholarly journals Randomized Pilot Trial of a Telephone Symptom Management Intervention for Symptomatic Lung Cancer Patients and Their Family Caregivers

2016 ◽  
Vol 52 (4) ◽  
pp. 469-482 ◽  
Author(s):  
Catherine E. Mosher ◽  
Joseph G. Winger ◽  
Nasser Hanna ◽  
Shadia I. Jalal ◽  
Lawrence H. Einhorn ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Family Caregivers ◽  
Symptom Management ◽  
Pilot Trial ◽  
Lung Cancer Patients ◽  
Management Intervention

scholarly journals Pilot Study of an Integrated Smartphone and Breathalyzer Contingency Management Intervention for Alcohol Use

2019 ◽  
Vol 14 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Oladunni Oluwoye ◽  
Hailey Reneau ◽  
Jalene Herron ◽  
Karl C. Alcover ◽  
Sterling McPherson ◽  
...  
Keyword(s):  
Pilot Study ◽  
Alcohol Use ◽  
Contingency Management ◽  
Management Intervention

scholarly journals Linking women experiencing incarceration to community-based HIV pre-exposure prophylaxis care: protocol of a pilot trial

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Susan E. Ramsey ◽  
Evan G. Ames ◽  
Lauren Brinkley-Rubinstein ◽  
Anne M. Teitelman ◽  
Jennifer Clarke ◽  
...  
Keyword(s):  
Pilot Trial ◽  
Community Based ◽  
Care Protocol ◽  
Exposure Prophylaxis

scholarly journals Is exposure to an effective contingency management intervention associated with more positive provider beliefs?

2012 ◽  
Vol 42 (4) ◽  
pp. 356-365 ◽  
Author(s):  
Kimberly C. Kirby ◽  
Carolyn M. Carpenedo ◽  
Maxine L. Stitzer ◽  
Karen L. Dugosh ◽  
Nancy M. Petry ◽  
...  
Keyword(s):  
Contingency Management ◽  
Management Intervention ◽  
Provider Beliefs

mMotiv8 : A smartphone‐based contingency management intervention to promote smoking cessation

2020 ◽  
Author(s):  
Jesse Dallery ◽  
Lesleigh Stinson ◽  
Hypatia Bolívar ◽  
François Modave ◽  
Ramzi G. Salloum ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Contingency Management ◽  
Management Intervention ◽  
Promote Smoking Cessation
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