scholarly journals The Generalizability of Randomized Controlled Trials of Self-Guided Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms: Systematic Review and Meta-Regression Analysis

10.2196/10113 ◽  
2018 ◽  
Vol 20 (11) ◽  
pp. e10113 ◽  
Author(s):  
Lorenzo Lorenzo-Luaces ◽  
Emily Johns ◽  
John R Keefe
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Depressive Symptoms ◽  
Cognitive Behavioral Therapy ◽  
Randomized Controlled Trials ◽  
Behavioral Therapy ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Meta Regression ◽  
Meta Regression Analysis

scholarly journals SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis

Critical Care ◽  
2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Harm-Jan de Grooth ◽  
Irma L. Geenen ◽  
Armand R. Girbes ◽  
Jean-Louis Vincent ◽  
Jean-Jacques Parienti ◽  
...  
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Meta Regression ◽  
Meta Regression Analysis

scholarly journals The prognostic significance of the alterations of pulmonary hemodynamics in patients with pulmonary arterial hypertension: a meta-regression analysis of randomized controlled trials

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Shih-Hsien Sung ◽  
Wan-Yu Yeh ◽  
Chern-En Chiang ◽  
Chi-Jung Huang ◽  
Wei-Ming Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Explanatory Power ◽  
Controlled Trials ◽  
Hemodynamic Changes ◽  
Randomized Controlled ◽  
Clinical Events ◽  
Pulmonary Arterial ◽  
Meta Regression ◽  
Meta Regression Analysis

Abstract Background Hemodynamic assessment in patients with pulmonary arterial hypertension (PAH) is essential for risk stratification and pharmacological management. However, the prognostic value of the hemodynamic changes after treatment is less well established. Objectives We investigated the prognostic impacts of the changes in hemodynamic indices, including mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), right atrial pressure (RAP), and cardiac output index (CI). We conducted this systematic review with meta-regression analysis on existing clinical trials. Methods We searched and identified all relevant randomized controlled trials from multiple databases. An analogous R2 index was used to quantify the proportion of variance explained by each predictor in the association with PAH patients’ prognosis. A total of 21 trials and 3306 individuals were enrolled. Results The changes in mPAP, PVR, RAP, and CI were all significantly associated with the change in 6MWD (∆6MWD). The change in mPAP was with the highest explanatory power for ∆6MWD (R2 analog = 0.740). Additionally, the changes in mPAP, PVR, and CI were independently predictive of adverse clinical events. The change in mPAP had the highest explanatory power for the clinical events (R2 analog = 0.911). Furthermore, the change in PVR was with the highest explanatory power for total mortality of PAH patients (R2 analog = 0.612). Conclusion Hemodynamic changes after treatment, including mPAP, PVR, CI, and RAP, were significantly associated with adverse clinical events or mortality in treated PAH patients. It is recommended that further studies be conducted to evaluate the changes in hemodynamic indices to guide drug titration. Systematic review registration PROSPERO CRD42019125157

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