Evaluation of the Relationship between the Znf804A Single Nucleotide Polymorphism Rs1344706 a/c Variant and Schizophrenia Subtype in Han Chinese Patients

2013 ◽  
Vol 45 (3) ◽  
pp. 269-278 ◽  
Author(s):  
Yongfeng Yang ◽  
Wenqiang Li ◽  
Ge Yang ◽  
Bo Xiao ◽  
Xiujuan Wang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Han Chinese ◽  
Chinese Patients ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
The Relationship

The grainyhead-like 2 gene (GRHL2 ) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese

2011 ◽  
Vol 121 (6) ◽  
pp. 1303-1307 ◽  
Author(s):  
Yan-Han Lin ◽  
Chen-Chi Wu ◽  
Chuan-Jen Hsu ◽  
Juen-Haur Hwang ◽  
Tien-Chen Liu
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Hearing Impairment ◽  
Han Chinese ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Age Related

scholarly journals Pathogenetic significance of C774T single nucleotide polymorphism of the endothelial NO synthase gene in the development of metabolic syndrome

2016 ◽  
Vol 62 (4) ◽  
pp. 447-452 ◽  
Author(s):  
N.S. Fattakhov ◽  
M.A. Vasilenko ◽  
D.A. Skuratovskaia ◽  
D.I. Kulikov ◽  
E.V. Kirienkova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Single Nucleotide Polymorphism ◽  
Serum Levels ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Nos3 Gene ◽  
Kaliningrad Region ◽  
The Relationship

The relationship between nitric oxide production and metabolic disorders and the role of endothelial nitric oxide synthase (eNOS or NOS3) in metabolic syndrome (MS) remain poorly understood and need deeper investigation. In this context the role of the NOS3 gene in pathogenesis of MS is of special interest. The aim of the study was to investigate association of NOS3 single nucleotide polymorphism C774T with risk of MS in the Slavic population of the Kaliningrad region and the relationship of this polymorphic variant with some parameters of endothelial dysfunction. The study included 128 patients (48 men and 80 women aged from 36 to 52 years) with MS. The control group consisted of 126 healthy volunteers (60 men and 66 women aged from 30 to 40 years). Genotyping was performed by real-time PCR. Serum nitrite levels were determined spectrophotometrically by the Griess method. Serum levels of endothelin-1 and eNOS were evaluated by ELISA. The study has shown association of T allele (OR=2.06; p=0.0004; CI: 1.38-3.08) and CT genotype (OR=1.97; p=0.014; CI: 1.14-3.40 ) C774T polymorphism of the NOS3 gene with risk of MS in the Slavic population of the Kaliningrad region. Allele C (OR=0.48; p=0.0004; CI: 0.32-0.72) and homozygous CC genotype (OR=0.41; p=0.001; CI: 0.24-0,69) C774T polymorphism of the NOS3 gene were associated with reduced risk of the development of MS. Significant differences in serum levels of eNOS and endothelin-1 depended on the CT and TT genotypes of C774T polymorphism of the NOS3 gene in MS.

scholarly journals The Relationship Between Lipid Metabolism and The Level of Albuminuria with Single Nucleotide Polymorphism -204A>C [rs 3808607] CYP7A1 Gene in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy

2019 ◽  
Vol 26 (3) ◽  
pp. 253-260
Author(s):  
Nadiia Demihova ◽  
Cherkashyna Lidiya ◽  
Olha Chernatska ◽  
Tetyana Mazur ◽  
Tetyana Aleksakhina ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Single Nucleotide Polymorphism ◽  
Diabetic Nephropathy ◽  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Group I ◽  
The Relationship

Abstract Background and aims. The purpose of our study was to determine the features of diabetic nephropathy, to identify the relationship between the level of albumin excretion, urine and lipid profile, genotype variants of the CYP7A1 gene in people with type 2 diabetes and diabetic nephropathy. Material and methods. Patients were divided into three groups. Normoalbinuria was detected in group I, and II - microalbuminuria, and III -macroalbuminuria. Determination of albumin to creatinine ratio was more accurate, although more expensive method. We examined single nucleotide polymorphism -204A> C [rs 3808607] of the promoter region of the CYP7A1 gene. Results. It was established that homozygotes by the major allele with genotype AA had lower values of albuminuria, atherogenic lipoproteins, total cholesterol, triglycerides and higher levels of anti-atherogenic lipoproteins than patients with AС and СС genotypes. Conclusion. The СС genotype was most unfavorable in the prognostic plan, since homozygotes for this minor allele were characterized by higher values of albuminuria, total cholesterol, triglycerides, and lower values of high-density lipoprotein

scholarly journals A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children

2016 ◽  
Vol 8 ◽  
pp. GEG.S38307 ◽  
Author(s):  
Daniel Amoako-Sakyi ◽  
Selorme Adukpo ◽  
Kwadwo A. Kusi ◽  
Daniel Dodoo ◽  
Michael F. Ofori ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Clinical Malaria ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Total Ige ◽  
Cytokine Levels ◽  
Polymerase Chain ◽  
The Relationship ◽  
Intronic Single Nucleotide Polymorphism ◽  
Malaria Severity

Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0.5 and 13 years. Total IgE and cytokine levels were measured by ELISA, while genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (RFLP). Compared with healthy controls, heterozygosity protected against clinical malaria: uncomplicated malaria (odds ratios [OR] = 0.13, P < 0.001), severe malarial anemia (OR = 0.18, P < 0.001), and cerebral malaria (OR = 0.39, P = 0.022). Levels of total IgE significantly differed among malaria phenotypes (P = 0.044) and rs3024974 genotypes (P = 0.037). Neither cytokine levels nor IL-6/IL-10 ratios were associated with malaria phenotypes or rs3024974 genotypes. This study suggests a role for rs3024974 in malaria pathogenesis and offers further insights into an IL-4/STAT6 pathway mutation in malaria pathogenesis.

scholarly journals Evaluation of the Genetic Diversity of Xylella fastidiosa Strains from Citrus and Coffee Hosts by Single-Nucleotide Polymorphism Markers

2007 ◽  
Vol 97 (12) ◽  
pp. 1543-1549 ◽  
Author(s):  
Ester Wickert ◽  
Marcos Antonio Machado ◽  
Eliana G. M. Lemos
Keyword(s):  
Genetic Diversity ◽  
Single Nucleotide Polymorphism ◽  
Dna Sequences ◽  
Xylella Fastidiosa ◽  
Snp Markers ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

The aim of this study was to obtain information about genetic diversity and make some inferences about the relationship of 27 strains of Xylella fastidiosa from different hosts and distinct geographical areas. Single-nucleotide polymorphism (SNP) molecular markers were identified in DNA sequences from 16 distinct regions of the genome of 24 strains of X. fastidiosa from coffee and citrus plants. Among the Brazilian strains, coffee-dependent strains have a greater number of SNPs (10 to 24 SNPs) than the citrus-based strains (2 to 12 SNPs); all the strains were compared with the sequenced strain 9a5c. The identified SNP markers were able to distinguish, for the first time, strains from citrus plants and coffee and showed that strains from coffee present higher genetic diversity than the others. These markers also have proven to be efficient for discriminating strains from the same host obtained from different geographic regions. X. fastidiosa, the causal agent of citrus variegated chlorosis, possesses genetic diversity, and the SNP markers were highly efficient for discriminating genetically close organisms.

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