scholarly journals Associations Between hOGG1 Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population

2014 ◽  
Vol 24 (5) ◽  
pp. 379-384 ◽  
Author(s):  
Megumi Hara ◽  
Kazuyo Nakamura ◽  
Hinako Nanri ◽  
Yuichiro Nishida ◽  
Asahi Hishida ◽  
...  
Keyword(s):  
Body Mass Index ◽  
General Population ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Glucose ◽  
Fasting Glucose Level ◽  
Japanese General Population ◽  
Ser326cys Polymorphism

scholarly journals Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

2020 ◽  
Vol 23 (1) ◽  
pp. 77-82
Author(s):  
V Vidović ◽  
N Maksimović ◽  
I Novaković ◽  
T Damnjanović ◽  
B Jekić ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Body Mass ◽  
Glucose Level ◽  
Neurotrophic Factor ◽  
Fasting Glucose ◽  
Fasting Glucose Level ◽  
Val66met Polymorphism ◽  
Glucose Levels

AbstractBrain-derived neurotrophic factor (BDNF) has an important role in energy balance. It suppresses food intake, reduces hepatic glucose production and converts white fat into brown fat in adipose tissue, leading to energy dissipation, lowered blood glucose and a lean phenotype. Studies have shown that the single nucleotide polymorphism (SNP) Val66Met within BDNF may be associated with obesity, insulin sensitivity, type 2 diabetes mellitus (T2DM) and dyslipidemia. The objective of the study was to investigate the association of the Val66Met polymorphism with body mass index (BMI), fasting glucose levels and lipid profile in Serbian adolescents. The study included 308 randomly selected healthy adolescents, 153 (49.68%) boys and 155 girls (50.32%), 15 years of age. Data including age, gender, height, weight, lipid profile and fasting glucose were recorded. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No association of this polymorphism was found with BMI and lipid profile. However, significant association was observed between this polymorphism and fasting blood glucose (FBG). Carriers of a Val/Val genotype had significantly higher mean values of fasting glucose level compared to carriers of Val/ Met and Met/Met genotypes (p = 0.01). To confirm these results multiple linear regression analysis was performed. Body mass index and gender were taken as covariates. Carriers of the Val/Val genotype had significantly higher levels of FBG (β = -0.152, p = 0.02). A statistically significant association between BMI and glucose level was also observed (β = 0.124,p = 0.033). This polymorphism could be associated with fasting glucose level in Serbian adolescents, thus further research would be of great interest to validate these results.

Nilotinib-mediated increase in fasting glucose level is reversible, does not convert to type 2 diabetes and is likely correlated with increased body mass index

2012 ◽  
Vol 36 (4) ◽  
pp. e66-e67 ◽  
Author(s):  
Massimo Breccia ◽  
Giuseppina Loglisci ◽  
Adriano Salaroli ◽  
Alessandra Serrao ◽  
Giuliana Alimena
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Glucose ◽  
Fasting Glucose Level

P6232Exploring the bottom of J-shaped curve association between serum uric acid and cardiovascular risks: description using a large Japanese general population

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Kawasoe ◽  
T Kubozono ◽  
S Ojima ◽  
H Miyahara ◽  
S Maenohara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
General Population ◽  
Cardiovascular Risk Factors ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Cardiovascular Risks ◽  
Japanese General Population

Abstract Background The J-shaped association between serum uric acid (SUA) and cardiovascular risks is known. However, the bottom of the J-shaped curve has not been elucidated because of the lack of epidemiological knowledge about hypouricemia. Purpose To explore the SUA levels related to the most preferable cardiovascular risks using data from a Japanese general population. Methods Data from 246,923 individuals (111,117 men and 135,806 women) who underwent routine health checkups between January 2001 and December 2015 were analyzed. The participants were divided into quartiles according to their SUA levels, and patients with hypouricemia (SUA level <2.0 mg/dL) were subdivided into two groups according to their distributions. We compared their characteristics, including their cardiovascular risks. Results The prevalence of hypouricemia was 0.46% overall, 0.21% for men, and 0.66% for women (P<0.001). The subjects with hypouricemia were divided into two groups according to SUA level: a lower hypouricemia group (0.4–1.1 mg/dL, which included a peak at 0.7–0.8 mg/dL) and a higher hypouricemia group (1.4–2.0 mg/dL). The two groups exhibited significanly different characteristics in several variables: body mass index and triglyceride in men, and age, body mass index, triglyceride, low-density lipoprotein cholesterol, and renal function in women. Furthermore, several cardiovascular risk factors showed the most preferable values in subjects with SUA 1.4–2.0 mg/dL (Figure). Conclusions There were two independent distributions in subjects with SUA ≤2.0 mg/dL. The individuals with SUA 1.4–2.0 mg/dL exhibited the most preferable values for several cardiovascular risk factors, suggesting an association with the bottom of the J-shaped curve between SUA and cardiovascular risks.

scholarly journals Effect of Body Weight Change on Blood Pressure in a Japanese General Population with a Body Mass Index ≥ 22 kg/m2

2019 ◽  
Vol 60 (6) ◽  
pp. 1381-1386 ◽  
Author(s):  
Hidetaka Itoh ◽  
Hidehiro Kaneko ◽  
Hiroyuki Kiriyama ◽  
Koki Nakanishi ◽  
Yoshiko Mizuno ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
General Population ◽  
Body Mass ◽  
Weight Change ◽  
Body Weight Change ◽  
Japanese General Population

U-shaped association between body mass index and proteinuria in a large Japanese general population sample

2013 ◽  
Vol 18 (1) ◽  
pp. 75-86 ◽  
Author(s):  
Yuji Sato ◽  
Shouichi Fujimoto ◽  
Tsuneo Konta ◽  
Kunitoshi Iseki ◽  
Toshiki Moriyama ◽  
...  
Keyword(s):  
Body Mass Index ◽  
General Population ◽  
Body Mass ◽  
Population Sample ◽  
General Population Sample ◽  
Japanese General Population

Abstract P202: The Impact of Snoring with and without Overweight on the Incidence of Hypertension among Japanese General Population

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Mako Nagayoshi ◽  
Takeshi Tanigawa ◽  
Kazumasa Yamagishi ◽  
Susumu Sakurai ◽  
Akihiko Kitamura ◽  
...  
Keyword(s):  
Body Mass Index ◽  
General Population ◽  
Body Mass ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Population Attributable Fraction ◽  
Longitudinal Impact ◽  
Incident Hypertension ◽  
Japanese General Population ◽  
The Impact

Introduction: Evidence for the longitudinal impact of snoring on incident hypertension in Asians is still limited. The objective of this study was to examine whether the impact of snoring with and without overweight (body mass index ≥25.0 kg/m 2 ) on the incidence of hypertension among Japanese general population. Hypothesis: We assessed the hypothesis that the impact of snoring on incident hypertension among Japanese general population was more evident for non-overweight (body mass index <25.0 kg/m 2 ) subjects probably because overweight is a primary determinant of both snoring and hypertension. Method: A total of 7,482 non-hypertensive persons (2,891 men and 4,591 women) aged 35-79 years from three communities in Japan who participated in the Circulatory Risk in Communities Study (CIRCS) were followed up for 7.9 years. Hazard ratios for the incidence of hypertension were calculated according to snoring (self-administered questionnaire) stratified by body mass index. Results: At baseline, 74 % of men and 59 % of women had sometimes or everyday snoring and 31 % of men and 28 % of women had being overweight. During the 7.9-year follow-up period, 1087 individuals (451 men and 636 women) developed hypertension. The multivariable-adjusted odds ratio (95%confidence interval) of incident hypertension for snoring compared with non-snoring was 1.37 (1.06 to 1.76) for men and 1.32 (1.10 to 1.58) for women. When stratified by body mass index at baseline, the significant association was observed only in non-overweight; the multivariable adjusted odds ratio of incident hypertension with non-overweight was 1.52 (1.12 to 2.04) for men and 1.39 (1.11 to 1.73) for women, and respective odds ratio for snoring with overweight was 1.11 (0.68 to 1.81) for men and 1.14 (0.83 to 1.53) for women compared with non-snoring categories although the interaction was not statistically significant. The population-attributable fraction (PAF) of snoring with non-overweight for incident hypertension was 26 % for men and 17% for women. Conclusions: Snoring may have larger impact on development hypertension among non-overweight Japanese men and women.

scholarly journals Erratum to: U-shaped association between body mass index and proteinuria in a large Japanese general population sample

2013 ◽  
Vol 18 (1) ◽  
pp. 87-87
Author(s):  
Yuji Sato ◽  
Shouichi Fujimoto ◽  
Tsuneo Konta ◽  
Kunitoshi Iseki ◽  
Toshiki Moriyama ◽  
...  
Keyword(s):  
Body Mass Index ◽  
General Population ◽  
Body Mass ◽  
Population Sample ◽  
General Population Sample ◽  
Japanese General Population

scholarly journals The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 8 (10) ◽  
pp. 1645 ◽  
Author(s):  
Yongin Cho ◽  
Namki Hong ◽  
Kyung-won Kim ◽  
Sung Cho ◽  
Minyoung Lee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Glucose Metabolism ◽  
General Population ◽  
Body Mass ◽  
Fasting Glucose ◽  
Weighted Mean Difference ◽  
Control Diet ◽  
Intermittent Fasting ◽  
Model Assessment

The effects of an intermittent fasting diet (IFD) in the general population are still controversial. In this study, we aimed to systematically evaluate the effectiveness of an IFD to reduce body mass index and glucose metabolism in the general population without diabetes mellitus. Cochrane, PubMed, and Embase databases were searched to identify randomized controlled trials and controlled clinical trials that compared an IFD with a regular diet or a continuous calorie restriction diet. The effectiveness of an IFD was estimated by the weighted mean difference (WMD) for several variables associated with glucometabolic parameters including body mass index (BMI) and fasting glucose. The pooled mean differences of outcomes were calculated using a random effects model. From 2814 studies identified through a literature search, we finally selected 12 articles (545 participants). Compared with a control diet, an IFD was associated with a significant decline in BMI (WMD, −0.75 kg/m2; 95% CI, −1.44 to −0.06), fasting glucose level (WMD, −4.16 mg/dL; 95% CI, −6.92 to −1.40), and homeostatic model assessment of insulin resistance (WMD, −0.54; 95% CI, −1.05 to −0.03). Fat mass (WMD, −0.98 kg; 95% CI, −2.32 to 0.36) tended to decrease in the IFD group with a significant increase in adiponectin (WMD, 1008.9 ng/mL; 95% CI, 140.5 to 1877.3) and a decrease in leptin (WMD, −0.51 ng/mL; 95% CI, −0.77 to −0.24) levels. An IFD may provide a significant metabolic benefit by improving glycemic control, insulin resistance, and adipokine concentration with a reduction of BMI in adults.

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