scholarly journals Arsenic in Drinking Water and Peripheral Nerve Conduction Velocity among Residents of a Chronically Arsenic-affected Area in Inner Mongolia

2006 ◽  
Vol 16 (5) ◽  
pp. 207-213 ◽  
Author(s):  
Yoshihisa Fujino ◽  
Xiaojuan Guo ◽  
Kiyoyumi Shirane ◽  
Jun Liu ◽  
Kegong Wu ◽  
...  
Keyword(s):  
Drinking Water ◽  
Peripheral Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Inner Mongolia ◽  
Nerve Conduction Velocity ◽  
Affected Area

scholarly journals AGE-RELATED PRESERVATION OF MOTOR NERVE CONDUCTION VELOCITY IN NEURONAL MTORC1 KNOCKDOWN MICE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S107-S107
Author(s):  
Stacy A Hussong ◽  
Veronica Galvan
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Conduction Velocity ◽  
Dietary Restriction ◽  
Nerve Conduction ◽  
Peripheral Nerves ◽  
Nerve Conduction Velocity ◽  
Age Related ◽  
Mtorc1 Signaling ◽  
Effects Of Aging

Abstract With age, peripheral nerves undergo demyelination along with overall decrease in peripheral nerve conduction velocity in both sensory and motor nerves. Loss of innervation in muscles is thought to be a major factor in causing age-related sarcopenia including a decrease in muscle function. Dietary restriction attenuates the detrimental effects of aging in mice. Reduction of mTOR signaling is hypothesized to have overlapping mechanisms with dietary restriction. Furthermore, inhibition of mTOR via rapamycin treatment is known to extend lifespan in mice as well as improve peripheral nerve myelination. Therefore, I hypothesized that reducing mTORC1 signaling in neurons would be able to ameliorate the deleterious effects of aging in peripheral nerves. An overall decrease in nerve conduction velocity was observed in both tail sensory and sural nerves with age (15 vs. 30 months). In neuronal mTORC1 KD animals, there was an age-related preservation of both sural and sciatic nerve conduction. Rapamycin treatment produced similar effects with a trend towards increased sciatic nerve conduction velocity in rapamycin-treated wild-type mice at 19 months. The preserve sciatic nerve conduction velocity could be partially explained by preserved myelination. Neuronal mTORC1 knockdown animals had more myelin in the sciatic nerve at 30 mo. as compared to age-matched controls. Overall, these data indicate that mTORC1 signaling plays a role in the age-related decline in peripheral nerve myelination as well as nerve conduction velocity. Future therapeutics could utilize rapamycin or other rapalogs to combat the decline in peripheral nerve function associated with age and other diseases as well.

Fetal nutrition and peripheral nerve conduction velocity

Neurology ◽  
1981 ◽  
Vol 31 (3) ◽  
pp. 327-327 ◽  
Author(s):  
R. O. Robinson ◽  
W. C. Robertson
Keyword(s):  
Peripheral Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Fetal Nutrition

Comparison of the Neurotoxicity of Several Chemicals Estimated by the Peripheral Nerve Conduction Velocity in Rats

1993 ◽  
Vol 62 (1) ◽  
pp. 148-154 ◽  
Author(s):  
K. Teramoto ◽  
F. Wakitani ◽  
S. Horiguchi ◽  
T. Jo ◽  
T. Yamamoto ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity
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