scholarly journals Molecular Markers for Long-term Survival in Stage IIIA (N2) NSCLC Patients

2021 ◽  
Vol 19 (1) ◽  
pp. 94-104
Author(s):  
ANCA NASTASE ◽  
SIMONA O. DIMA ◽  
AUDREY LUPO ◽  
VICTORIA LASZLO ◽  
REBECCA TAGETT ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Stage Iiia ◽  
Term Survival ◽  
Long Term Survival ◽  
Nsclc Patients

scholarly journals P050 Long-Term Survival of Stage IIIA-N2 NSCLC Patients with Interstitial Lung Diseases

2018 ◽  
Vol 13 (12) ◽  
pp. S1069
Author(s):  
J. Watanabe ◽  
H. Horinouchi ◽  
Y. Shinno ◽  
S. Murakami ◽  
Y. Goto ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Stage Iiia ◽  
Term Survival ◽  
Long Term Survival ◽  
Nsclc Patients

OA20.01 Long Term Survival in Operable Stage Iiia Nsclc Patients Treated With Neoadjuvant Nivolumab Plus Chemotherapy - Nadim Study

2021 ◽  
Vol 16 (10) ◽  
pp. S883
Author(s):  
M. Provencio ◽  
E. Nadal ◽  
A. Insa ◽  
M.R. García Campelo ◽  
D. Pereiro ◽  
...  
Keyword(s):  
Stage Iiia ◽  
Term Survival ◽  
Long Term Survival ◽  
Iiia Nsclc ◽  
Nsclc Patients

scholarly journals Long-term survival without surgery in NSCLC patients with synchronous brain oligometastasis: systemic chemotherapy revisited

2018 ◽  
Vol 10 (3) ◽  
pp. 1696-1702 ◽  
Author(s):  
Jun Sato ◽  
Hidehito Horinouchi ◽  
Yasushi Goto ◽  
Shintaro Kanda ◽  
Yutaka Fujiwara ◽  
...  
Keyword(s):  
Systemic Chemotherapy ◽  
Term Survival ◽  
Long Term Survival ◽  
Nsclc Patients

scholarly journals Long-term survival of stage T4N0-1 and single station IIIA-N2 NSCLC patients treated with definitive chemo-radiotherapy using individualised isotoxic accelerated radiotherapy (INDAR)

2014 ◽  
Vol 110 (3) ◽  
pp. 482-487 ◽  
Author(s):  
Bart Reymen ◽  
Angela van Baardwijk ◽  
Rinus Wanders ◽  
Jacques Borger ◽  
Anne-Marie C. Dingemans ◽  
...  
Keyword(s):  
Term Survival ◽  
Long Term Survival ◽  
Accelerated Radiotherapy ◽  
Single Station ◽  
Nsclc Patients

scholarly journals Long-term survival of a patient with an inoperable thymic neuroendocrine tumor stage IIIa under sole treatment with Viscum album extract

Medicine ◽  
2020 ◽  
Vol 99 (5) ◽  
pp. e18990 ◽  
Author(s):  
María Reynel ◽  
Yván Villegas ◽  
Paul G. Werthmann ◽  
Helmut Kiene ◽  
Gunver S. Kienle
Keyword(s):  
Neuroendocrine Tumor ◽  
Viscum Album ◽  
Tumor Stage ◽  
Stage Iiia ◽  
Term Survival ◽  
Long Term Survival

Neoadjuvant weekly paclitaxel/cisplatin chemotherapy (WTP) with concurrent thoracic chemoradiation followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NCLC): Phase II study

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 17036-17036 ◽  
Author(s):  
S. Kim ◽  
H. Sohn ◽  
C. Suh ◽  
J. Ryu ◽  
E. Choi ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Univariate Analysis ◽  
Whole Body ◽  
Stage Iiia ◽  
Term Survival ◽  
Weekly Chemotherapy ◽  
Long Term Survival ◽  
Thoracic Radiation ◽  
Iiia Nsclc

17036 Background: To investigate the role of weekly chemotherapy with paclitaxel/cisplatin and concurrent thoracic radiation (RT) as neoadjuvant therapy before surgical resection for patients with N2-IIIA NSCLC. Methods: Patients with pathologically proven N2 (pN2) and operable stage IIIA NSCLC were eligible. Six weekly chemotherapy with paclitaxel (50 mg/m2)/cisplatin (20 mg/m2) was given with concurrent thoracic RT (1.8 Gy/fraction once a day, 45 Gy) during 5 weeks. Chest CT, whole body PET were checked before and 3 weeks after chemoradiation. For the patients without clearing pN2 nodes or with pT3 after surgical resection, boost RT (20 Gy) was given. Results: From Jan. 2002 to Nov. 2005, 38 patients were enrolled. Median follow-up time was 20 months: gender (male: female, 30:8,), age (median 56, 42–67). Of them, 31 patients underwent surgical resection. Three patients showed brain metastasis during chmoradiation. Two patients refused surgical resection after chemoradiation. One patient showed severe radiation pneumonitis and was not fit for the operation. One patient showed lung to lung metastases before surgical resection. Of the 31 patients who underwent surgical resection, 14 (45.2%) showed pN0–1, and 7 (22.6%) showed pathologic complete remission (CR). Three year overall survival rate of all patients was 37.7% (median 35.9 months) and 3 year progression free survival was 34.2% (median 18 months). In univariate analysis, clearing N2 node and pathologic CR after surgery were the factors that could predict long-term survival. And the 2nd PET after chemoradiaiton could not expect clearing N2 nodes after surgical resection: sensitivity 44%, specificity 46%. As toxicities of WTP, hypersensivity reaction to paclitaxel and pneumonia with neutropenia were noted in 1 patient each. Severe radiation pneumonits was noted in 4 (of them 3 were given 65 Gy). Conclusions: WTP followed by surgical resection for N2-stage IIIA NSCLC was feasible. Clearing N2 nodes or pathologic CR after surgical resection were the factors of long-term survival. The usefulness of 2nd PET to expect the clearing N2 nodes was not adequate. No significant financial relationships to disclose.

Randomized trial of amifostine in locally advanced non-small cell lung cancer (NSCLC) patients receiving chemotherapy and hyperfractionated radiation (HRT): Long-term survival results of Radiation Therapy Oncology Group (RTOG) 9801

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7529-7529
Author(s):  
B. Movsas ◽  
J. Moughan ◽  
C. Langer ◽  
M. Werner-Wasik ◽  
N. Nicolaou ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Radiation Therapy Oncology Group ◽  
Disease Free Survival ◽  
Rank Test ◽  
Term Survival ◽  
Long Term Survival ◽  
Patient Reported ◽  
Nsclc Patients

7529 Purpose: This analysis was conducted to address the potential antitumor effect of amifostine (AM) in NSCLC patients enrolled on RTOG-9801. The long-term survival results of RTOG-9801 are presented here. Methods: 243 patients (pts) with stage II/IIIAB NSCLC received induction paclitaxel (P) 225 mg/m2IV days 1, 22 and carboplatin (C) AUC 6 days 1, 22 and then concurrent weekly P (50 mg/m2) and C (AUC 2) and HRT (69.6 Gy at 1.2 Gy BID). Pts were randomly assigned to AM 500 mg IV 4x/week or no-AM during chemoradiation. Treatment differences for overall and disease-free survival (OS & DFS) were analyzed with the log-rank test; Gray's test was used for time to progression (TTP). Results: 118 pts were randomly assigned to receive AM and 121 to no-AM (4 pts were ineligible). The median follow-up for pts still alive is 52.3 months (mo) for the AM-arm and 58.3 mo for the no-AM arm (16.6 vs 17.9 for all pts). There are no significant differences in OS, DFS or TTP between arms. The median survival, 3-yr, and 5-yr OS are 17.1 mo, 27% and 17% (AM-arm) vs 18.4 mo, 28% and 16% (no-AM arm) (p=0.97). Grade 3/4/5 late-RT toxicities are similar (11%/3%/2% AM-arm vs 14%/4%/2% no-AM arm). Conclusion: While an earlier publication reported that amifostine did not reduce objective measures of severe esophagitis in RTOG-9801, patient-reported outcome analyses suggested a possible advantage to AM with decreased pain and swallowing symptoms (J Clin Oncol 23:2145–2154, 2005). This long-term follow-up analysis on survival shows no evidence of tumor radioprotection due to amifostine. The promising 5-yr OS suggests that induction paclitaxel/carboplatin (P/C) followed by concurrent RT and weekly low-dose P/C is comparable to other regimens using cisplatin doublets at higher dosages every 3–4 weeks. Research supported by NCI and Medimmune Oncology. No significant financial relationships to disclose.

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