scholarly journals Cisplatin and Pemetrexed Have Distinctive Growth-inhibitory Effects in Monotherapy and Combination Therapy on KRAS-dependent A549 Lung Cancer Cells

2021 ◽  
Vol 18 (4) ◽  
pp. 579-590
Author(s):  
MD MOHIUDDIN ◽  
KAZUO KASAHARA
Keyword(s):  
Lung Cancer ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Inhibitory Effects ◽  
Growth Inhibitory ◽  
A549 Lung

Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect

RSC Advances ◽  
2014 ◽  
Vol 4 (38) ◽  
pp. 19887-19890 ◽  
Author(s):  
Su-Yun Bai ◽  
Xi Dai ◽  
Bao-Xiang Zhao ◽  
Jun-Ying Miao
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Hsp90 Inhibitor ◽  
Lung Cancer Cells ◽  
Inhibitory Effects ◽  
Strong Growth ◽  
Growth Inhibitory

A novel fluorescent HSP90 inhibitor with strong growth inhibitory effects on lung cancer cells was developed.

scholarly journals Growth inhibitory effects of miR‐221 and miR‐222 in non‐small cell lung cancer cells

2015 ◽  
Vol 4 (4) ◽  
pp. 551-564 ◽  
Author(s):  
Ryo Yamashita ◽  
Mitsuo Sato ◽  
Tomohiko Kakumu ◽  
Tetsunari Hase ◽  
Naoyuki Yogo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Inhibitory Effects ◽  
Small Cell Lung ◽  
Growth Inhibitory

scholarly journals Indomethacin-Enhanced Anticancer Effect of Arsenic Trioxide in A549 Cell Line: Involvement of Apoptosis and Phospho-ERK and p38 MAPK Pathways

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Ali Mandegary ◽  
Maryam Torshabi ◽  
Mohammad Seyedabadi ◽  
Bagher Amirheidari ◽  
Elham Sharif ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Arsenic Trioxide ◽  
Cytotoxic Effect ◽  
Caspase 3 ◽  
Mapk Pathway ◽  
Lung Cancer Cells ◽  
Gene And Protein Expression ◽  
A549 Lung

Background. Focusing on novel drug combinations that target different pathways especially apoptosis and MAPK could be a rationale for combination therapy in successful treatment of lung cancer. Concurrent use of cyclooxygenase (COX) inhibitors with arsenic trioxide (ATO) might be a possible treatment option.Methods. Cytotoxicity of ATO, dexamethasone (Dex), celecoxib (Cel), and Indomethacin (Indo) individually or in combination was determined at 24, 48, and 72 hrs in A549 lung cancer cells. The COX-2 gene and protein expression, MAPK pathway proteins, and caspase-3 activity were studied for the most cytotoxic combinations.Results. The IC50s of ATO and Indo were 68.7 μmol/L and 396.5 μmol/L, respectively. Treatment of cells with combinations of clinically relevant concentrations of ATO and Indo resulted in greater growth inhibition and apoptosis induction than did either agent alone. Caspase-3 activity was considerably high in the presence of ATO and Indo but showed no difference in single or combination use. Phosphorylation of p38 and ERK1/2 was remarkable in the concurrent presence of both drugs.Conclusions. Combination therapy with ATO and Indo exerted a very potent in vitro cytotoxic effect against A549 lung cancer cells. Activation of ERK and p38 pathways might be the mechanism of higher cytotoxic effect of ATO-Indo combination.

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