scholarly journals A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell

2021 ◽  
Vol 18 (2) ◽  
pp. 133-146
Author(s):  
MASARU TERASAKI ◽  
TAKUYA INOUE ◽  
WATARU MURASE ◽  
ATSUHITO KUBOTA ◽  
HIROYUKI KOJIMA ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

2017 ◽  
Vol 26 (2) ◽  
pp. 199-202
Author(s):  
Remus Cornea ◽  
Sorina Taban ◽  
Cristian Suciu ◽  
Codruta Lazureanu ◽  
Alis Dema
Keyword(s):  
Histopathological Examination ◽  
Intraepithelial Neoplasia ◽  
Heterotopic Pancreas ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Unique Case ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Pancreatic Endocrine Neoplasm ◽  
First Case ◽  
Mucinous Neoplasms

We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.

BRCA2 Dysfunction Promotes Malignant Transformation of Pancreatic Intraepithelial Neoplasia

2013 ◽  
Vol 13 (2) ◽  
pp. 261-269 ◽  
Author(s):  
Qi Wang ◽  
Hongrui Liu ◽  
Tingting liu ◽  
Shizhen Shu ◽  
He Jiang ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

Pancreatic Intraepithelial Neoplasia

2001 ◽  
Vol 25 (5) ◽  
pp. 579-586 ◽  
Author(s):  
Ralph H. Hruban ◽  
N. Volkan Adsay ◽  
Jorge Albores–Saavedra ◽  
Carolyn Compton ◽  
Elizabeth S. Garrett ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

scholarly journals Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

Gut ◽  
2021 ◽  
pp. gutjnl-2020-321112
Author(s):  
Dror Kolodkin-Gal ◽  
Lior Roitman ◽  
Yossi Ovadya ◽  
Narmen Azazmeh ◽  
Benjamin Assouline ◽  
...  
Keyword(s):  
Tumour Growth ◽  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Preventive Therapy ◽  
Ductal Adenocarcinoma ◽  
Potential Contribution ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Promoting Effect ◽  
Paracrine Effects ◽  
Bcl2 Family

ObjectiveCellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent cells are present in premalignant pancreatic intraepithelial neoplasia (PanIN) lesions, yet their effects on the disease are poorly characterised. It is currently unknown whether senolytic drugs, aimed at eliminating senescent cells from lesions, could be beneficial in blocking tumour development.DesignTo uncover the functions of senescent cells and their potential contribution to early pancreatic tumourigenesis, we isolated and characterised senescent cells from PanINs formed in a Kras-driven mouse model, and tested the consequences of their targeted elimination through senolytic treatment.ResultsWe found that senescent PanIN cells exert a tumour-promoting effect through expression of a proinflammatory signature that includes high Cox2 levels. Senolytic treatment with the Bcl2-family inhibitor ABT-737 eliminated Cox2-expressing senescent cells, and an intermittent short-duration treatment course dramatically reduced PanIN development and progression to pancreatic ductal adenocarcinoma.ConclusionsThese findings reveal that senescent PanIN cells support tumour growth and progression, and provide a first indication that elimination of senescent cells may be effective as preventive therapy for the progression of precancerous lesions.

Association of aging and ARHGAP17 variation with pancreatic intraepithelial neoplasia

Pancreatology ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. S14
Author(s):  
Y. Matsuda ◽  
M. Tanaka ◽  
A. Suzuki ◽  
A. Seki ◽  
K. Nonaka ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

A case of pancreatic intraepithelial neoplasia detected by pancreatic duct dilation

2021 ◽  
Vol 99 (1) ◽  
pp. 146-148
Author(s):  
Hironori Tanei ◽  
Reina Tanaka ◽  
Takayoshi Tsuchiya ◽  
Kentaro Ishii ◽  
Ryosuke Tonozuka ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

Incidentally Discovered Pancreatic Intraepithelial Neoplasia: What Is Its Clinical Significance?

2013 ◽  
Vol 20 (11) ◽  
pp. 3643-3647 ◽  
Author(s):  
Ioannis T. Konstantinidis ◽  
Eduardo F. Vinuela ◽  
Laura H. Tang ◽  
David S. Klimstra ◽  
Michael I. D’Angelica ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

scholarly journals Cyclooxygenase 2 Expression in Pancreatic Adenocarcinoma and Pancreatic Intraepithelial Neoplasia

2002 ◽  
Vol 118 (2) ◽  
pp. 194-201 ◽  
Author(s):  
Anirban Maitra ◽  
Raheela Ashfaq ◽  
Carla R. Gunn ◽  
Ayman Rahman ◽  
Charles J. Yeo ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Intraepithelial Neoplasia ◽  
Cyclooxygenase 2 ◽  
Pancreatic Intraepithelial Neoplasia
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