scholarly journals Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix

2020 ◽  
Vol 17 (5) ◽  
pp. 627-641
Author(s):  
HERA JUNG ◽  
GO EUN BAE ◽  
HYE MIN KIM ◽  
HYUN-SOO KIM
Keyword(s):  
Uterine Cervix ◽  
Mucinous Carcinoma ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

Magnetic Resonance Appearance of Gastric-Type Adenocarcinoma of the Uterine Cervix in Comparison With That of Usual-Type Endocervical Adenocarcinoma: A Pitfall of Newly Described Unusual Subtype of Endocervical Adenocarcinoma

2014 ◽  
Vol 24 (8) ◽  
pp. 1474-1479 ◽  
Author(s):  
Aki Kido ◽  
Yoshiki Mikami ◽  
Takashi Koyama ◽  
Masako Kataoka ◽  
Fuki Shitano ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Uterine Cervix ◽  
Growth Pattern ◽  
Cervical Canal ◽  
Imaging Features ◽  
Characteristic Appearance ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

ObjectiveThe aim of this study was to evaluate the characteristics of gastric-type adenocarcinoma (GAS) of the uterine cervix, compared with usual-type endocervical adenocarcinoma (UEA) and squamous cell carcinoma (SCC), using magnetic resonance (MR) imaging.Materials and MethodsA total of 15 histopathologically defined GASs, 12 UEAs, and 40 SCCs were retrieved from archive files and were included for evaluation. Microscopic features, as well as topography and tumor growth pattern, and presence or absence of coexistence of cystic cavities were evaluated. Accuracy of evaluation for parametrial tissue and vaginal wall invasion was also evaluated by 2 diagnostic radiologists, independently, without clinical information on cases.ResultsThirteen (86.70%) of the 15 cases of GAS exhibited tumors in the higher portion of cervical canal or the entire cervix. On the other hand, SCCs and UEAs were mainly located in the lower portion of cervical canal, at a frequency of 21 of 40 (52.5%) and 9 of 12 (75.0%), respectively. Involvement of the corpus was observed more frequently in cases of GAS with an occurrence of 8 of 15 (53.3%), whereas in all cases of UEA and in 5 of the 40 cases of SCC, the corpus was free of tumor. In GAS cases, the predominant pattern of growth was highly infiltrating and endophytic (14/15, 93.3%), whereas an exophytic growth pattern was observed in 31 (77.5%) of the 40 SCC cases and 11 (91.7%) of the 12 UEA cases. Cystic cavities associated with tumors were identified in only 1 case of SCC but occurred in 12 (80.0%) of the 15 GASs and 4 (33.3%) of the 12 UEAs. Diagnostic accuracies of more than 70% and more than 60% were reached in parametrial invasion and vaginal invasion, respectively, in GAS.ConclusionDistinctive MR imaging features of GAS were infiltrating mass of endophytic growth, location in the upper cervical canal, and association with tiny cysts. This characteristic appearance can be a clue for the evaluation of extent of tumor based on MR imaging.

Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group

2018 ◽  
Vol 28 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Atsumi Kojima ◽  
Muneaki Shimada ◽  
Yoshiki Mikami ◽  
Shoji Nagao ◽  
Nobuhiro Takeshima ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Cell Carcinoma ◽  
Uterine Cervix ◽  
Mucinous Carcinoma ◽  
Stage Ii ◽  
World Health ◽  
Serous Carcinoma ◽  
Endocervical Adenocarcinoma ◽  
Alternative Treatment Strategy ◽  
Gastric Type

ObjectiveGastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix, characterized by aggressive clinical behavior and absence of high-risk human papillomavirus. We conducted this study to evaluate the chemosensitivity of GAS compared with that of usual-type endocervical adenocarcinoma (UEA) in patients who had been enrolled in our previous study.MethodsOf 52 patients from our previous phase 2 study (SGSG005) of neoadjuvant chemotherapy with docetaxel and carboplatin for stage IB2 to IIB nonsquamous cervical cancer, 47 (stage IB2, 12; stage IIA2, 7; stage IIB, 28) were enrolled in this study with written informed consent. The biopsy specimens before neoadjuvant chemotherapy and surgical specimens after chemotherapy were centrally reviewed based on the updated World Health Organization classification (2014).ResultsOf 47 patients with nonsquamous cell carcinoma, 20 (42.6%) were diagnosed with UEA, 13 (27.7%) with GAS, 12 (25.5%) with adenosquamous carcinoma, and 1 patient each (2%) with small cell carcinoma and serous carcinoma. Consequently, 33 patients, consisting of 20 patients with UEA and 13 patients with GAS, were eligible for the current study. The response rate of GAS was significantly lower than that of UEA (46.2% vs 85.0%, P = 0.048). Of 16 cases of stage II UEA, 11 (68.8%) were downstaged on microscopic examination of postsurgical specimens, but none of the 8 patients with stage II GAS showed any response (P < 0.01). Two inoperative tumors were GAS. With a median follow-up duration of 56 months, the 5-year progression-free and overall survival rates of GAS were significantly worse than those of UEA (38.5% vs 75.0% [P = 0.011] and 36.9% vs 90.0% [P < 0.001], respectively).ConclusionsThese findings suggest that GAS should be distinguished from UEA by its chemoresistance, necessitating an alternative treatment strategy established for this distinct subtype of endocervical adenocarcinoma.

Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix

2020 ◽  
Author(s):  
Eunhyang Park ◽  
Sang Wun Kim ◽  
Sunghoon Kim ◽  
Hyun-Soo Kim ◽  
Jung-Yun Lee ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Mucinous Carcinoma ◽  
Genetic Characteristics ◽  
Gastric Type

scholarly journals A Retrospective Study on Incidence, Diagnosis, and Clinical Outcome of Gastric-type Endocervical Adenocarcinoma in a Single Institution

2021 ◽  
Author(s):  
Anna Radomska ◽  
Daniel Lee ◽  
Heather Neufeld ◽  
Nancy Korte ◽  
Emina Torlakovic ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Kinase Inhibitor ◽  
P53 Protein ◽  
Progesterone Receptors ◽  
Cervical Adenocarcinoma ◽  
Single Institution ◽  
Mutant Type ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

Abstract Background: Gastric-type endocervical adenocarcinoma is rare but the most common subtype of cervical adenocarcinoma not associated with human papillomavirus. It is more aggressive with a shorter five-year survival rate compared to human papillomavirus-associated usual type endocervical adenocarcinoma. The objectives of our study were to determine the incidence and clinical-pathological characteristics of Gastric-type endocervical adenocarcinoma in a single institution. Methods: Twenty four cases of invasive cervical adenocarcinoma were identified between January 2000 and December 2015, from the Saskatoon Health Region pathology database using International Endocervical Adenocarcinoma Criteria and Classification to retrospectively classify endocervical adenocarcinoma. Immunohistochemistry was performed with antibodies for Gastric mucin-6 (MUC-6), p16INK4a, cyclin-dependent kinase inhibitor 2A (p16), p53 protein (p53), estrogen and progesterone receptors. Clinical and pathological data was retrieved from pathology reports and charts. Statistical analysis was performed using Mann-Whitney U test and Chi-Square test.Results: Using the International Endocervical Adenocarcinoma Criteria and Classification criteria, 19 cases (79.2%) were classified as human papillomavirus-associated usual type endocervical adenocarcinoma, and five cases (20.8%) as Gastric-type endocervical adenocarcinoma. In our study 40% of Gastric-type endocervical adenocarcinoma cases presented at stage III compared to none of the usual type endocervical carcinoma cases. All the Gastric-type endocervical adenocarcinoma cases were positive for MUC-6, and negative for p16. 60% Gastric-type endocervical adenocarcinoma cases demonstrated mutant type p53 staining. In contrast, 84.2% of human papillomavirus-associated usual type endocervical adenocarcinoma cases showed block like nuclear and cytoplasmic positivity with p16 antibodies. The Gastric-type endocervical adenocarcinoma group had significantly shorter median survival time than human papillomavirus-associated usual type endocervical adenocarcinoma group, Gastric-type endocervical adenocarcinoma is 22 months compared to human papillomavirus-associated usual type endocervical adenocarcinoma at 118 months (p = 0.043). Conclusions: In this study, Gastric-type endocervical adenocarcinoma accounted for 20.8% of all cervical adenocarcinoma with higher stage at presentation and shorter overall survival. Histomorphology and immunohistochemistry for MUC-6 and p16 could differentiate between Gastric-type endocervical adenocarcinoma and human papillomavirus-associated usual type endocervical adenocarcinoma.

scholarly journals Stromal p16 Overexpression in Gastric-type Mucinous Carcinoma of the Uterine Cervix

2018 ◽  
Vol 38 (6) ◽  
pp. 3551-3558 ◽  
Author(s):  
TAEK CHUNG ◽  
SUNG-IM DO ◽  
KIYONG NA ◽  
GEON KIM ◽  
YOUNG IN JEONG ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Mucinous Carcinoma ◽  
Gastric Type ◽  
P16 Overexpression

scholarly journals A retrospective study on incidence, diagnosis, and clinical outcome of gastric-type endocervical adenocarcinoma in a single institution

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Anna Radomska ◽  
Daniel Lee ◽  
Heather Neufeld ◽  
Nancy Korte ◽  
Emina Torlakovic ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Kinase Inhibitor ◽  
P53 Protein ◽  
Progesterone Receptors ◽  
Cervical Adenocarcinoma ◽  
Single Institution ◽  
Mutant Type ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

Abstract Background Gastric-type endocervical adenocarcinoma is rare but the most common subtype of cervical adenocarcinoma not associated with human papillomavirus. It is more aggressive with a shorter five-year survival rate compared to human papillomavirus-associated usual type endocervical adenocarcinoma. The objectives of our study were to determine the incidence and clinical-pathological characteristics of Gastric-type endocervical adenocarcinoma in a single institution. Methods Twenty four cases of invasive cervical adenocarcinoma were identified between January 2000 and December 2015, from the Saskatoon Health Region pathology database using International Endocervical Adenocarcinoma Criteria and Classification to retrospectively classify endocervical adenocarcinoma. Immunohistochemistry was performed with antibodies for Gastric mucin-6 (MUC-6), p16INK4a, cyclin-dependent kinase inhibitor 2A (p16), p53 protein (p53), estrogen and progesterone receptors. Clinical and pathological data was retrieved from pathology reports and charts. Statistical analysis was performed using Mann-Whitney U test and Chi-Square test. Results Using the International Endocervical Adenocarcinoma Criteria and Classification criteria, 19 cases (79.2%) were classified as human papillomavirus-associated usual type endocervical adenocarcinoma, and five cases (20.8%) as Gastric-type endocervical adenocarcinoma. In our study 40% of Gastric-type endocervical adenocarcinoma cases presented at stage III compared to none of the usual type endocervical carcinoma cases. All the Gastric-type endocervical adenocarcinoma cases were positive for MUC-6, and negative for p16. 60% Gastric-type endocervical adenocarcinoma cases demonstrated mutant type p53 staining. In contrast, 84.2% of human papillomavirus-associated usual type endocervical adenocarcinoma cases showed block like nuclear and cytoplasmic positivity with p16 antibodies. The Gastric-type endocervical adenocarcinoma group had significantly shorter median survival time than human papillomavirus-associated usual type endocervical adenocarcinoma group, Gastric-type endocervical adenocarcinoma is 22 months compared to human papillomavirus-associated usual type endocervical adenocarcinoma at 118 months (p = 0.043). Conclusions In this study, Gastric-type endocervical adenocarcinoma accounted for 20.8% of all cervical adenocarcinoma with higher stage at presentation and shorter overall survival. Criteria proposed by International Endocervical Adenocarcinoma Criteria and Classification (IECC) are simple and reproducible in differentiating between, HPV- associated (HPVA) and non HPV associated (NHPVA) endocervical adenocarcinoma. Although none of the IHC assays is specific for GAS, but p16, MUC-6, ER, PR and p53 may further aid in confirming GAS and to differentiate it from benign and malignant mimics.

scholarly journals Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case

2018 ◽  
Vol 61 (1) ◽  
pp. 165 ◽  
Author(s):  
Chul Min Park ◽  
Hyun Min Koh ◽  
Soyun Park ◽  
Hye Sim Kang ◽  
Soon Sup Shim ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Interesting Case ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

scholarly journals Analysis of gastric-type mucinous carcinoma of the uterine cervix — An aggressive tumor with a poor prognosis: A multi-institutional study

2019 ◽  
Vol 153 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Shin Nishio ◽  
Yoshiki Mikami ◽  
Hideki Tokunaga ◽  
Nobuo Yaegashi ◽  
Toyomi Satoh ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Poor Prognosis ◽  
Mucinous Carcinoma ◽  
Gastric Type ◽  
Aggressive Tumor
Sign in / Sign up

Export Citation Format

Share Document