scholarly journals STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer

2020 ◽  
Vol 17 (5) ◽  
pp. 509-516
Author(s):  
SHUNSUKE NAKAMURA ◽  
MITSURO KANDA ◽  
DAI SHIMIZU ◽  
KOUICHI SAWAKI ◽  
CHIE TANAKA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Biomarker

Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker

2011 ◽  
Vol 5 (9-10) ◽  
pp. 567-567
Author(s):  
Chien-Wei Tseng ◽  
Jyh-Chin Yang ◽  
Chiung-Nien Chen ◽  
Hsuan-Cheng Huang ◽  
Kai-Neng Chuang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Prognostic Biomarker ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients

2021 ◽  
pp. 153568
Author(s):  
Mingxia Jiang ◽  
Ling Qi ◽  
Kexin Jin ◽  
Lisha Li ◽  
Yiming Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Prognostic Biomarker ◽  
Gastric Cancer Patients

scholarly journals PI3K/AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1923 ◽  
Author(s):  
Bo-Kyung Kim ◽  
Jae-Ho Cheong ◽  
Joo-Young Im ◽  
Hyun Seung Ban ◽  
Seon-Kyu Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Target Genes ◽  
Prognostic Biomarker ◽  
Xenograft Model ◽  
Gastric Cancer Cells ◽  
Metastatic Lesions ◽  
Proliferation And Metastasis ◽  
Cancer Tissues ◽  
Sphere Formation

Although gastric cancer is a common cause of cancer mortality worldwide, its biological heterogeneity limits the available therapeutic options. Therefore, identifying novel therapeutic targets for developing effective targeted therapy of gastric cancer is a pressing need. Here, we investigate molecular function and regulatory mechanisms of Vestigial-like 1 (VGLL1) in gastric cancer. Microarray analysis of 556 gastric cancer tissues revealed that VGLL1 was a prognostic biomarker that correlated with PI3KCA and PI3KCB. VGLL1 regulates the proliferation of gastric cancer cells, as shown in live cell imaging, sphere formation, and in vivo xenograft model. Tail vein injection of NUGC3 cells expressing shVGLL1 resulted in less lung metastasis occurring when compared to the control. In contrast, larger metastatic lesions in lung and liver were detected in the VGLL1-overexpressing NUGC3 cell xenograft excision mouse model. Importantly, VGLL1 expression is transcriptionally regulated by the PI3K-AKT-β-catenin pathway. Subsequently, MMP9, a key molecule in gastric cancer, was explored as one of target genes that were transcribed by VGLL1-TEAD4 complex, a component of the transcription factor. Taken together, PI3K/AKT/β-catenin signaling regulates the transcription of VGLL1, which promotes the proliferation and metastasis in gastric cancer. This finding suggests VGLL1 as a novel prognostic biomarker and a potential therapeutic target.

scholarly journals ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer

2015 ◽  
Vol 13 (4) ◽  
pp. 156 ◽  
Author(s):  
Jong-Lyul Park ◽  
Mirang Kim ◽  
Kyu-Sang Song ◽  
Seon-Young Kim ◽  
Yong Sung Kim
Keyword(s):  
Gastric Cancer ◽  
Prognostic Biomarker

scholarly journals Circulating circERBB2 as a potential prognostic biomarker for gastric cancer: An investigative study

2020 ◽  
Vol 111 (11) ◽  
pp. 4177-4186
Author(s):  
Kenji Nanishi ◽  
Hirotaka Konishi ◽  
Katsutoshi Shoda ◽  
Tomohiro Arita ◽  
Toshiyuki Kosuga ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Biomarker

scholarly journals Identification of serum exosomal lncRNA MIAT as a novel diagnostic and prognostic biomarker for gastric cancer

2020 ◽  
Vol 34 (8) ◽  
Author(s):  
Hao Xu ◽  
Jie Zhou ◽  
Jin Tang ◽  
Xuli Min ◽  
Tingting Yi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Biomarker

scholarly journals Gastric juice piR‐1245: A promising prognostic biomarker for gastric cancer

2019 ◽  
Vol 34 (4) ◽  
Author(s):  
Xiaorong Zhou ◽  
Jianhong Liu ◽  
Aifeng Meng ◽  
Lihong Zhang ◽  
Min Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Juice ◽  
Prognostic Biomarker

scholarly journals Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer

2019 ◽  
Vol 7 (16) ◽  
pp. 380-380 ◽  
Author(s):  
Jie Yi ◽  
Liwen Ren ◽  
Jie Wu ◽  
Wan Li ◽  
Xiangjin Zheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Biomarker
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