Visceral Adipose Mass and Radiation Pneumonitis After Concurrent Chemoradiotherapy in Patients With Non-small-cell Lung Cancer

2021 ◽  
Vol 1 (2) ◽  
pp. 61-67
Author(s):  
KUNIAKI KATSUI ◽  
TAKESHI OGATA ◽  
SOICHI SUGIYAMA ◽  
KOTARO YOSHIO ◽  
MASAHIRO KURODA ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Concurrent Chemoradiotherapy ◽  
Radiation Pneumonitis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Visceral Adipose ◽  
Subcutaneous Adipose ◽  
Adipose Mass

Aim: To investigate whether muscle and adipose mass are associated with radiation pneumonitis (RP) in patients with non-small cell lung cancer undergoing preoperative concurrent chemoradiotherapy. Patients and Methods: We calculated body mass index and determined skeletal muscle, psoas muscle, visceral adipose tissue (VAI), and subcutaneous adipose tissue indices, and visceral-to-subcutaneous adipose tissue area ratio for patients using computed tomography. We examined their relationship with grade 2 or more RP. Results: Among 94 patients, 28 experienced grade 2 or more RP. On multivariate analysis, only VAI was associated with grade 2 or more RP (all p=0.026). The 6-month incidence rates of grade 2 or more RP were 21.4% and 36.8% in patients with VAI 39 and ≥39 cm2/m2, respectively. Conclusion: High visceral adipose mass is associated with grade 2 or more RP in patients undergoing preoperative concurrent chemoradiotherapy. Measuring visceral adipose mass may help to predict RP occurrence. Further studies are needed to validate our findings.

scholarly journals Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kuniaki Katsui ◽  
Takeshi Ogata ◽  
Soichi Sugiyama ◽  
Kotaro Yoshio ◽  
Masahiro Kuroda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multivariate Analysis ◽  
Adipose Tissue ◽  
Small Cell Lung Cancer ◽  
Subcutaneous Adipose Tissue ◽  
Univariate Analysis ◽  
Small Cell ◽  
Stage Iii ◽  
Small Cell Lung ◽  
Subcutaneous Adipose

AbstractWe intended to investigate whether muscle and adipose masses were associated with prognosis among patients with stage III non-small-cell lung cancer (NSCLC) who were undergoing chemoradiotherapy (CCRT). We retrospectively explored data of patients with stage III NSCLC who underwent definitive CCRT (≥ 60 Gy) between January 2004 and March 2018 at our hospital. We examined the relationship of overall survival (OS) with body mass index (BMI), skeletal muscle index (SMI), psoas muscle index (PMI), visceral adipose tissue index (VAI), subcutaneous adipose tissue index (SAI), and visceral-to-subcutaneous adipose tissue area ratio (VSR) using log-rank tests for the univariate analysis and Cox proportional hazard models for the multivariate analysis. Overall, 16, 32, and 12 patients had stage IIIA, IIIB, and IIIC NSCLC, respectively. The total radiotherapy dose ranged from 60 Gy/30 fractions to 66 Gy/33 fractions. In the univariate analysis, the performance status (PS), BMI, and SMI were associated with OS, whereas the PMI, VAI, SAI, and VSR were not. In the multivariate analysis, the PS and SMI were associated with OS. The hazard ratios and 95% confidence intervals were 2.91 and 1.28–6.64 for PS, and 2.36 and 1.15–4.85 for SMI, respectively. The 1, 3, and 5-year OS rates were 92.1%, 59.6%, and 51.0% in patients with high SMI, and 63.6%, 53.8%, and 17.9% in patients with low SMI, respectively. The SMI correlated with prognosis in our study population, whereas adipose mass did not. Therefore, sarcopenia should be considered while predicting the OS in such patients.

scholarly journals Radiation pneumonitis after definitive concurrent chemoradiotherapy with cisplatin/docetaxel for non‐small cell lung cancer: Analysis of dose‐volume parameters

2020 ◽  
Vol 9 (13) ◽  
pp. 4540-4549
Author(s):  
Kuniaki Katsui ◽  
Takeshi Ogata ◽  
Kenta Watanabe ◽  
Norihisa Katayama ◽  
Masahiro Kuroda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Radiation Pneumonitis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Dose Volume

scholarly journals Cytokine Profiles of Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy with Regards to Radiation Pneumonitis Severity

2021 ◽  
Vol 10 (4) ◽  
pp. 699
Author(s):  
Bae Kwon Jeong ◽  
Jin Hyun Kim ◽  
Myeong Hee Jung ◽  
Ki Mun Kang ◽  
Yun Hee Lee
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Radiation Pneumonitis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Ifn Γ

The immunologic aspects of radiation pneumonitis (RP) are unclear. We analyzed variations in cytokine profiles between patients with grade (Gr) 0–1 and Gr ≥ 2 RP. Fifteen patients undergoing concurrent chemoradiotherapy for non-small cell lung cancer were included. Blood samples of 9 patients with Gr 0–1 and 6 with Gr ≥ 2 RP were obtained from the Biobank. Cytokine levels were evaluated using an enzyme linked immunosorbent assay at before radiotherapy (RT) initiation, 1, 3, and 6 weeks post-RT initiation, and 1 month post-RT completion. Concentrations of granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-10, IL-13, IL-17, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β were analyzed; none were related to the occurrence of Gr ≥ 2 RP at pre-RT initiation. At 3 weeks, relative changes in the G-CSF, IL-6, and IFN-γ levels differed significantly between the groups (p = 0.026, 0.05 and 0.026, respectively). One month post-RT completion, relative changes of IL-17 showed significant differences (p = 0.045); however, relative changes in TNF-α, IL-10, IL-13, and TGF-β, did not differ significantly. Evaluation of changes in IL-6, G-CSF, and IFN-γ at 3 weeks after RT initiation can identify patients pre-disposed to severe RP. The mechanism of variation in cytokine levels in relation to RP severity warrants further investigation.

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