The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell Death

2021 ◽  
Vol 41 (12) ◽  
pp. 5973-5985
Author(s):  
JAN-PHILIPP RUFF ◽  
ANNA-LAURA KRETZ ◽  
MARKO KORNMANN ◽  
DORIS HENNE-BRUNS ◽  
JOHANNES LEMKE ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
The Novel ◽  
Pancreatic Cancer Cells ◽  
Orally Bioavailable ◽  
Cdk9 Inhibitor

Galectin-3 is modulated in pancreatic cancer cells under hypoxia and nutrient deprivation

2020 ◽  
Vol 401 (10) ◽  
pp. 1153-1165 ◽  
Author(s):  
Antônio F. da Silva Filho ◽  
Lucas B. Tavares ◽  
Maira G. R. Pitta ◽  
Eduardo I. C. Beltrão ◽  
Moacyr J. B. M. Rêgo
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Mrna Expression ◽  
Cancer Cells ◽  
Ductal Adenocarcinoma ◽  
Reverse Transcription Pcr ◽  
Pancreatic Cancer Cells ◽  
Through Flow ◽  
Galectin 3

AbstractPancreatic ductal adenocarcinoma is one of the most aggressive tumors with a microenvironment marked by hypoxia and starvation. Galectin-3 has been evaluated in solid tumors and seems to present both pro/anti-tumor effects. So, this study aims to characterize the expression of Galectin-3 from pancreatic tumor cells and analyze its influence for cell survive and motility in mimetic microenvironment. For this, cell cycle and cell death were accessed through flow cytometry. Characterization of inside and outside Galectin-3 was performed through Real-Time Quantitative Reverse Transcription PCR (qRT-PCR), immunofluorescence, Western blot, and ELISA. Consequences of Galectin-3 extracellular inhibition were investigated using cell death and scratch assays. PANC-1 showed increased Galectin-3 mRNA expression when cultivated in hypoxia for 24 and 48 h. After 24 h in simultaneously hypoxic/deprived incubation, PANC-1 shows increased Galectin-3 protein and secreted levels. For Mia PaCa-2, cultivation in deprivation was determinant for the increasing in Galectin-3 mRNA expression. When cultivated in simultaneously hypoxic/deprived condition, Mia PaCa-2 also presented increasing for the Galectin-3 secreted levels. Treatment of PANC-1 cells with lactose increased the death rate when cells were incubated simultaneously hypoxic/deprived condition. Therefore, it is possible to conclude that the microenvironmental conditions modulate the Galectin-3 expression on the transcriptional and translational levels for pancreatic cancer cells.

scholarly journals The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells

2018 ◽  
Vol 17 (2) ◽  
pp. 575-587 ◽  
Author(s):  
Y. K. Stella Man ◽  
James A. Davies ◽  
Lynda Coughlan ◽  
Constantia Pantelidou ◽  
Alfonso Blázquez-Moreno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
The Novel ◽  
Pancreatic Cancer Cells

scholarly journals MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway

Autophagy ◽  
2017 ◽  
Vol 13 (4) ◽  
pp. 703-714 ◽  
Author(s):  
Longhao Sun ◽  
Limei Hu ◽  
David Cogdell ◽  
Li Lu ◽  
Chao Gao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Stat3 Pathway ◽  
Pancreatic Cancer Cells ◽  
Related Cell

Chemotherapy and autophagy-mediated cell death in pancreatic cancer cells

Pancreatology ◽  
2012 ◽  
Vol 12 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Alejandro Ropolo ◽  
Claudia I. Bagnes ◽  
Maria I. Molejon ◽  
Andrea Lo Re ◽  
Veronica Boggio ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells

Plumbagin, Isolated from Plumbago zeylanica, Induces Cell Death through Apoptosis in Human Pancreatic Cancer Cells

Pancreatology ◽  
2009 ◽  
Vol 9 (6) ◽  
pp. 797-809 ◽  
Author(s):  
Chien-An Chen ◽  
Hen-Hong Chang ◽  
Chung-Yu Kao ◽  
Tung-Hu Tsai ◽  
Yu-Jen Chen
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Plumbago Zeylanica ◽  
Pancreatic Cancer Cells
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