Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor

2021 ◽  
Vol 41 (10) ◽  
pp. 5249-5254
Author(s):  
ERI ODA ◽  
KENSUKE YAMAMURA ◽  
YOSHIHIRO HARA ◽  
KAZUKI MATSUMURA ◽  
SHINICHI AKAHOSHI ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Metastasis ◽  
Neuroendocrine Tumor ◽  
Intrahepatic Cholangiocarcinoma ◽  
Pancreatic Neuroendocrine Tumor ◽  
Bile Duct Adenoma

scholarly journals Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation-like Feature Associated with Bile Duct Adenoma

2015 ◽  
Vol 49 (6) ◽  
pp. 531-534 ◽  
Author(s):  
Ah-Young Kwon ◽  
Hye Jin Lee ◽  
Hee Jung An ◽  
Haeyoun Kang ◽  
Jin-Hyung Heo ◽  
...  
Keyword(s):  
Bile Duct ◽  
Intrahepatic Cholangiocarcinoma ◽  
Ductal Plate ◽  
Ductal Plate Malformation ◽  
Bile Duct Adenoma

scholarly journals A Case of Intrahepatic Cholangiocarcinoma in a Bile Duct Adenoma

2013 ◽  
Vol 46 (5) ◽  
pp. 356-361
Author(s):  
Hidetaka Sugihara ◽  
Akira Chikamoto ◽  
Shin-ichi Akaboshi ◽  
Hiroyuki Komori ◽  
Masayuki Watanabe ◽  
...  
Keyword(s):  
Bile Duct ◽  
Intrahepatic Cholangiocarcinoma ◽  
Bile Duct Adenoma

Abstract #849: A Rare Case of Ectopic Adrenocorticotropin Hormone Syndrome from a Pancreatic Neuroendocrine Tumor with Liver Metastasis

2017 ◽  
Vol 23 ◽  
pp. 188-189
Author(s):  
Linda Nguyen ◽  
Marina Kishlyansky ◽  
Priyanka Mittar ◽  
Gabor Varadi ◽  
Corrado Minimo ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Neuroendocrine Tumor ◽  
Rare Case ◽  
Pancreatic Neuroendocrine Tumor

Novel immunohistochemical markers differentiate intrahepatic cholangiocarcinoma from benign bile duct lesions

2016 ◽  
Vol 69 (7) ◽  
pp. 619-626 ◽  
Author(s):  
Stefanie Bertram ◽  
Juliet Padden ◽  
Julia Kälsch ◽  
Maike Ahrens ◽  
Leona Pott ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Bile Duct ◽  
Intrahepatic Cholangiocarcinoma ◽  
Immunohistochemical Markers ◽  
Hsp 27 ◽  
Malignant Lesions ◽  
The Difference ◽  
Bile Duct Lesions ◽  
Cluster Of Differentiation ◽  
Bile Duct Adenoma

AimsThe distinction between intrahepatic cholangiocarcinoma (ICC) and benign bile duct lesions can be challenging. Using our previously identified potential biomarkers for ICC, we examined whether these are useful for the differential diagnosis of ICC, bile duct adenoma and reactive bile duct proliferations in an immunohistochemical approach and identified a diagnostic marker panel including known biomarkers.MethodsSubjects included samples from 77 patients with ICC, 33 patients with bile duct adenoma and 47 patients with ductular reactions in liver cirrhosis. Our previously identified biomarkers (stress-induced phosphoprotein 1 (STIP1), SerpinH1, 14-3-3Sigma) were tested immunohistochemically following comparison with candidates from the literature (cluster of differentiation 56, heat shock protein (HSP)27, HSP70, B-cell-lymphoma2, p53, ki67).ResultsThe expression of SerpinH1 and 14-3-3Sigma was significantly higher in ICC than in bile duct adenomas and ductular reactions (p<0.05), whereas STIP1 expression was significantly higher (p<0.05) in ICC than in ductular reactions, but the difference to the bile duct adenoma group was not significant. A panel of the biomarker SerpinH1, 14-3-3Sigma and ki67 (≥2 marker positive) showed a high diagnostic accuracy (sensitivity 87.8%, specificity 95.9%, accuracy 91.8%) in the differential diagnosis of ICC versus non-malignant bile duct lesions.ConclusionsThis suggests that 14-3-3Sigma and SerpinH1 may be useful in the differential diagnosis of malignant, benign and reactive bile duct lesions in addition to ki67 where a cut-off of >5% might be used for the distinction of malignant and non-malignant lesions.

Bile duct adenoma may be a precursor lesion of small duct type intrahepatic cholangiocarcinoma

2020 ◽  
Vol 78 (2) ◽  
pp. 310-320
Author(s):  
Motoko Sasaki ◽  
Yasunori Sato ◽  
Yasuni Nakanuma
Keyword(s):  
Bile Duct ◽  
Intrahepatic Cholangiocarcinoma ◽  
Precursor Lesion ◽  
Small Duct ◽  
Bile Duct Adenoma
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