470 nm LED Irradiation Inhibits the Invasiveness of CD133-positive Human Colorectal Cancer Stem Cells by Suppressing the Cyclooxygenase-2/prostaglandin E2 Pathway

2021 ◽  
Vol 41 (3) ◽  
pp. 1407-1420
Author(s):  
SANGJOON MO ◽  
HYUN JEONG KU ◽  
SUN-HYANG CHOI ◽  
HYE JUNG JEONG ◽  
DONG-GUK PARK ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Prostaglandin E2 ◽  
Cyclooxygenase 2 ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Stem Cells ◽  
Led Irradiation

scholarly journals Author Correction: KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jiong Li ◽  
Bo Yu ◽  
Peng Deng ◽  
Yingduan Cheng ◽  
Yongxin Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Stem Cells

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells

2019 ◽  
Vol 79 (20) ◽  
pp. 5151-5158 ◽  
Author(s):  
Junko Mukohyama ◽  
Taichi Isobe ◽  
Qingjiang Hu ◽  
Takanori Hayashi ◽  
Takashi Watanabe ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Stem Cells

scholarly journals KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Jiong Li ◽  
Bo Yu ◽  
Peng Deng ◽  
Yingduan Cheng ◽  
Yongxin Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gene Transcription ◽  
Target Gene ◽  
Histone Demethylases ◽  
Human Colorectal Cancer ◽  
Tumorigenic Potential ◽  
Colorectal Cancer Stem Cells ◽  
Target Gene Transcription

Abstract Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant. While genetic mutations associated with human colorectal cancer development are well-known, little is known about how and whether epigenetic factors specifically contribute to the functional properties of human colorectal CSCs. Here we report that the KDM3 family of histone demethylases plays an important role in tumorigenic potential and survival of human colorectal CSCs by epigenetically activating Wnt target gene transcription. The depletion of KDM3 inhibits tumorigenic growth and chemoresistance of human colorectal CSCs. Mechanistically, KDM3 not only directly erases repressive H3K9me2 marks, but also helps to recruit histone methyltransferase MLL1 to promote H3K4 methylation, thereby promoting Wnt target gene transcription. Our results suggest that KDM3 is a critical epigenetic factor in Wnt signalling that orchestrates chromatin changes and transcription in human colorectal CSCs, identifying potential therapeutic targets for effective elimination of CSCs.

Single-cell evolution and molecular characterization of human colorectal cancer stem cells.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15699-e15699
Author(s):  
Xiaoyan Zhang ◽  
Ling Yang ◽  
Qiang Hou ◽  
Ming Huang ◽  
Hong Fang Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Single Cell ◽  
Molecular Characterization ◽  
Human Colorectal Cancer ◽  
Cell Evolution ◽  
Colorectal Cancer Stem Cells

scholarly journals Abstract 1157: Single-cell transcriptmoics identifies rhamm positive proliferative cells within human colorectal cancer stem cells

2019 ◽  
Author(s):  
Michitaka Nakano ◽  
Kikushige Yoshikane ◽  
Kohta Miyawaki ◽  
Shinichi Mizuno ◽  
Kyoko Yamaguchi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Single Cell ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Stem Cells
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