Significance of P16INK4A Expression and PTEN Loss of Heterozygosity in Human Papilloma Virus-related Oral Squamous Cell Carcinoma

2020 ◽  
Vol 40 (11) ◽  
pp. 6355-6366
Author(s):  
VALDENIRA DE JESUS OLIVEIRA KATO ◽  
MICHELLE CARVALHO DE ABREU ◽  
ALBERTO MITSUYUKI DE BRITO KATO ◽  
LUCAS LACERDA DE SOUZA ◽  
FLAVIA SIROTHEAU CORREA PONTES ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Papilloma Virus ◽  
Pten Loss ◽  
P16ink4a Expression

Human papilloma virus in oral squamous cell carcinoma in a Mexican population

2005 ◽  
Vol 99 (3) ◽  
pp. 311-315 ◽  
Author(s):  
Blanca R. Ibieta ◽  
Marcela Lizano ◽  
Mauricio Frı́as-Mendivil ◽  
José L. Barrera ◽  
Adela Carrillo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mexican Population ◽  
Papilloma Virus

scholarly journals Human Papilloma Virus 18 Detection in Oral Squamous Cell Carcinoma and Potentially Malignant Lesions Using Saliva Samples

2012 ◽  
Vol 13 (12) ◽  
pp. 6109-6113 ◽  
Author(s):  
Khor Goot-Heah ◽  
Thong Kwai-Lin ◽  
Gabriele Ruth Anisah Froemming ◽  
Mannil Thomas Abraham ◽  
Nik Mohd Mazuan Nik Mohd Rosdy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Malignant Lesions

scholarly journals Detection of Human Papilloma Virus in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

2021 ◽  
Vol 17 (3) ◽  
pp. 279-285
Author(s):  
Snehashish Ghosh ◽  
Sartaj Singh Wazir ◽  
Rajesh Shah ◽  
Manoj Kumar Upadhyay ◽  
Rahul Gupta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Potentially Malignant Disorders ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Human Papilloma Virus 16

Introduction: Human Papilloma Virus 16 and 18 affects the keratinocytes of oral mucosa and skin and can lead to the development of dysplastic lesions and ultimately into invasive oral squamous cell carcinoma. The objective of the present study was to evaluate the presence of human Papilloma virus 16 and 18 DNA in already diagnosed oral potentially malignant disorders and oral squamous cell carcinoma. Methods: 200 biopsy specimens (50 each) of already diagnosed leukoplakia, oral lichen planus (OLP), oral submucous fibrosis (OSMF) and oral squamous cell carcinoma was included for the study. A total 50 control tissue sections, which were obtained during removal of impacted teeth were also included in the study. All 250 specimens were subjected to polymerase chain reaction (PCR) for the identification of HPV 16 and 18. The results are analyzed using Statistical Package of Social Sciences (SPSS) version 16 software and Pearson’s chi square test was used for statistical analysis. Results: HPV 16 and 18 was noted in all the OPMDS and oral cancer specimens but the results were not statistically significant. However, not even a single case of control tissue showed the presence of HPV 16 and 18. Conclusions: The results of the present study shows HPV 16 and 18 is present in oral cancer as well as OPMDS, therefore it could be implicated in the pathogenesis of the above mentioned conditions.

scholarly journals Assessment of Role of Human Papilloma Virus in Patients with Oral Squamous Cell Carcinoma

2019 ◽  
Vol 15 (2) ◽  
pp. 125-127
Author(s):  
Krishan Kumar Tyagi ◽  
Megha Pradhan ◽  
Rajbir Kaur Grewal ◽  
Prabesh Sherchan ◽  
KSA Pasha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Control Group ◽  
Papilloma Virus ◽  
Mucosal Tissues ◽  
Well Differentiated

Background: Head and neck malignancies include malignancies instigating in the oral cavity, the orophar-ynx, the hypopharynx and the larynx. We planned the present study to assess the role of human papilloma virus (HPV) in patients with oral squamous cell carcinoma (OSCC). Methods: The present study included assessment of role of human papilloma virus in patients with oral squamous cell carcinoma. A total of 50 histopathologic proven cases of well differentiated OSCC were included in the present study. A total of 50 healthy oral mucosal tissues (controls) were also included in the present study. The controls were obtained while surgical removing the impacted teeth. DNA was obtained from the tissue sections and underwent Polymerization chain reaction for identification of HPV 16/18. All the results were summarized in Microsoft excel sheet and were analyzed by SPSS software. Results: HPV was absent in all the cases of control group, whereas among the OSCC group, the HPV was detected in 46 percent of the cases. In the remaining 54 per-cent of the cases of the OSCC group, HPV was absent. Significant results were obtained while comparing the presence of HPV in between the OSCC group and the control group. Conclusions: HPV was present in sig-nificant number of OSCC cases. Therefore; HPV might play a contributing role in the etio-pathogenesis of OSCC.

Prevalence of human papilloma virus in oral squamous cell carcinoma and a review of literature

2014 ◽  
Vol 67 (5) ◽  
pp. 649-662
Author(s):  
Akindayo Akinyamoju ◽  
Bukola Adeyemi ◽  
Bamidele Kolude ◽  
Ahmed Lawal ◽  
Jonathan Lawoyin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Review Of Literature ◽  
Papilloma Virus
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