Tumor-to-nipple Distance Should Not Preclude Nipple-sparing Mastectomy in Breast Cancer Patients. Personal Experience and Literature Review

2020 ◽  
Vol 40 (6) ◽  
pp. 3543-3550 ◽  
Author(s):  
PIERO FREGATTI ◽  
MARCO GIPPONI ◽  
GABRIELE ZOPPOLI ◽  
MATTEO LAMBERTINI ◽  
EVA BLONDEAUX ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Literature Review ◽  
Cancer Patients ◽  
Personal Experience ◽  
Breast Cancer Patients ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Nipple-sparing mastectomy: accuracy of sub-areolar frozen section for predicting occult NAC involvement in breast cancer patients

The Breast ◽  
2017 ◽  
Vol 32 ◽  
pp. S113
Author(s):  
M. D’Alonzo ◽  
A. Fenoglio ◽  
G. De Rosa ◽  
P. Campisi ◽  
P. Balocco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Frozen Section ◽  
Breast Cancer Patients ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer Patients

2017 ◽  
Vol 213 (4) ◽  
pp. 810-813 ◽  
Author(s):  
Brittany L. Murphy ◽  
Tanya L. Hoskin ◽  
Judy C. Boughey ◽  
Amy C. Degnim ◽  
James W. Jakub ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Node Positive ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing ◽  
Positive Breast Cancer

Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer patients.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 60-60 ◽  
Author(s):  
Brittany L. Murphy ◽  
Tanya L. Hoskin ◽  
Judy Caroline Boughey ◽  
Amy C. Degnim ◽  
James W. Jakub ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Oncologic Outcomes ◽  
Her2 Status ◽  
Breast Cancer Patients ◽  
Node Positive ◽  
Primary Surgery ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

60 Background: Indications for nipple-sparing mastectomy (NSM) with immediate reconstruction have expanded. For cancer patients, NSM is thought best-suited for early stage patients, with nodal involvement initially viewed as a relative contraindication. We undertook this study to evaluate the use and early outcomes of NSM in node-positive (LN+) breast cancer. Methods: We identified 240 cancers in 226 patients (14 bilateral) scheduled for NSM and operated on at our institution 1/2009-6/2014. Data on intraoperative conversion from NSM, recurrence and follow-up was abstracted from the medical record. Chi-square and long-rank tests were used for statistical analysis. P-values < 0.05 were considered significant. Results: Of 240 cancers, 182 were LN- and 58 were LN+. More LN+ patients had T2/T3 tumors (27/58, 47%) than LN- patients (31/182, 17%), p < 0.0001, but ER and HER2 status was similar. Of 58 LN+ cases, 19 (33%) were cN1 confirmed by positive LN cytology and 39 (67%) were cN0 but LN+ at operation. 10 patients LN+ at diagnosis received neoadjuvant therapy (NT) followed by operation (at which 6 were pLN+ and 4 rendered ypN0); 39 cN0 (4 NT, 35 primary surgery) and 9 cN1 primary surgery patients were pLN+ at operation with a median of 1 LN+. NSM was successful in 13/14 LN+ NT patients (93%) and 39/44 LN+ primary surgery patients (89%), p = 0.64. Six LN+ patients (10%) were converted to skin-sparing mastectomy (SSM) at initial operation based on frozen section pathology (n = 5) or at a second operation (n = 1) vs 13/182 LN- patients (7%), p = 0.44. Among cancer patients treated with NSM, 7 locoregional recurrences (5 in LN+, 2 in LN- patients) occurred at 25 mos median follow-up. 3-year locoregional disease-free estimates were 87% (95% CI 75-100%) for LN+ vs 99% (95% CI 97-100%) for LN- patients, p = 0.007. One nipple-areolar recurrence occurred, in a LN- patient. 3-year breast cancer-specific survival was 97% (95% CI 92-100%) in LN+ vs 99% (95% CI 98-100%) in LN- patients, p = 0.40. Conclusions: Conversion from planned NSM to SSM did not differ significantly between LN+ and LN- patients. Short-term oncologic outcomes were satisfactory. These data suggest that NSM may be appropriate for carefully selected LN+ breast cancer patients.

Loco-regional recurrence after nipple-sparing mastectomy in breast cancer patients

The Breast ◽  
2019 ◽  
Vol 44 ◽  
pp. S105
Author(s):  
P. Chirappapha ◽  
P. Thaweepworadej ◽  
P. Lertsithichai ◽  
T. Sukarayothin ◽  
M. Leesombatpaiboon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Regional Recurrence ◽  
Breast Cancer Patients ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing

Surgical and Oncologic Outcomes of Nipple-Sparing Mastectomy for a Cohort of Breast Cancer Patients, Including Cases with High-Risk Features

2020 ◽  
Vol 20 (4) ◽  
pp. 353-358
Author(s):  
Elena Parvez ◽  
Karyne Martel ◽  
Dominique Morency ◽  
Sinziana Dumitra ◽  
Ari N. Meguerditchian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Oncologic Outcomes ◽  
Breast Cancer Patients ◽  
Nipple Sparing Mastectomy ◽  
Nipple Sparing
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