Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes

2020 ◽  
Vol 40 (3) ◽  
pp. 1375-1385 ◽  
Author(s):  
VASILIKI GKRETSI ◽  
ANDREAS STYLIANOU ◽  
MARIA KALLI ◽  
MARIA LOUCA ◽  
CHRYSOVALANTIS VOUTOURI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Growth Differentiation Factor 15 ◽  
Breast Cancer Cell Invasion ◽  
Differentiation Factor

scholarly journals Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion

2015 ◽  
Vol 26 (19) ◽  
pp. 3464-3479 ◽  
Author(s):  
Victoria Hoskin ◽  
Alvin Szeto ◽  
Abdi Ghaffari ◽  
Peter A. Greer ◽  
Graham P. Côté ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Molecular Mechanisms ◽  
Metastatic Progression ◽  
Cancer Cell Invasion ◽  
Breast Cancer Cell Invasion ◽  
Associated Proteins

Up-regulation of the cytoskeleton linker protein ezrin frequently occurs in aggressive cancer types and is closely linked with metastatic progression. However, the underlying molecular mechanisms detailing how ezrin is involved in the invasive and metastatic phenotype remain unclear. Here we report a novel function of ezrin in regulating focal adhesion (FA) and invadopodia dynamics, two key processes required for efficient invasion to occur. We show that depletion of ezrin expression in invasive breast cancer cells impairs both FA and invadopodia turnover. We also demonstrate that ezrin-depleted cells display reduced calpain-mediated cleavage of the FA and invadopodia-associated proteins talin, focal adhesion kinase (FAK), and cortactin and reduced calpain-1–specific membrane localization, suggesting a requirement for ezrin in maintaining proper localization and activity of calpain-1. Furthermore, we show that ezrin is required for cell directionality, early lung seeding, and distant organ colonization but not primary tumor growth. Collectively our results unveil a novel mechanism by which ezrin regulates breast cancer cell invasion and metastasis.

Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase

2017 ◽  
Vol 118 (5) ◽  
pp. 1273-1273 ◽  
Author(s):  
Madhura Joglekar ◽  
Weam O. Elbazanti ◽  
Matthew D. Weitzman ◽  
Heather L. Lehman ◽  
Kenneth L. van Golen
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Inflammatory Breast Cancer ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Breast Cancer Cell Invasion ◽  
Caveolin 1 ◽  
Rhoc Gtpase ◽  
Inflammatory Breast Cancer Cell

scholarly journals Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion

Oncotarget ◽  
2013 ◽  
Vol 4 (9) ◽  
pp. 1449-1460 ◽  
Author(s):  
Eva Rietkötter ◽  
Kerstin Menck ◽  
Annalen Bleckmann ◽  
Katja Farhat ◽  
Meike Schaffrinski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zoledronic Acid ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Breast Cancer Cell Invasion

scholarly journals Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling

Oncogene ◽  
2011 ◽  
Vol 31 (25) ◽  
pp. 3086-3097 ◽  
Author(s):  
Y C Liao ◽  
J W Ruan ◽  
I Lua ◽  
M H Li ◽  
W L Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Breast Cancer Cell Invasion

Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion

2009 ◽  
Vol 284 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Severin Pinilla ◽  
Eckhard Alt ◽  
F.J. Abdul Khalek ◽  
Constantin Jotzu ◽  
Fabian Muehlberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Breast Cancer Cell Invasion ◽  
Resident Stem Cells ◽  
Promote Breast Cancer
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