scholarly journals Etomidate Suppresses Invasion and Migration of Human A549 Lung Adenocarcinoma Cells

2018 ◽  
Vol 39 (1) ◽  
pp. 215-223 ◽  
Author(s):  
CHIN-NAN CHU ◽  
KING-CHUEN WU ◽  
WAI-SHAN CHUNG ◽  
LI-CHENG ZHENG ◽  
TA-KUO JUAN ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Invasion And Migration ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
And Migration ◽  
Human A549 ◽  
A549 Lung

LncRNA TTN‐AS1 drives invasion and migration of lung adenocarcinoma cells via modulation of miR‐4677‐3p/ZEB1 axis

2019 ◽  
Vol 120 (10) ◽  
pp. 17131-17141 ◽  
Author(s):  
Yuanbo Zhong ◽  
Jin Wang ◽  
Wen Lv ◽  
Jianzhong Xu ◽  
Shanshan Mei ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Invasion And Migration ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
And Migration

scholarly journals C/EBPα Suppresses Lung Adenocarcinoma Cell Invasion and Migration by Inhibiting β-Catenin

2017 ◽  
Vol 42 (5) ◽  
pp. 1779-1788 ◽  
Author(s):  
Jinchang Lu ◽  
Chunling Du ◽  
Junxia Yao ◽  
Bo Wu ◽  
Yanhong Duan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Adenocarcinoma ◽  
Cell Invasion ◽  
Migration And Invasion ◽  
Adenocarcinoma Cell ◽  
Invasion And Migration ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
And Migration

Background/Aims: The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) is a basic leucine zipper transcription factor that plays essential roles in tumor progression. Although decreased or absent C/EBPα expression in many cancers suggests a possible role for C/EBPα as a tumor suppressor, the functions of C/EBPα in lung adenocarcinoma remain unclear. Methods: Here, C/EBPα expression levels in 26 lung adenocarcinoma and para-carcinoma tissue samples were detected by qRT-PCR and immunohistochemistry. Cell transwell assays, wound healing assay and three-dimensional spheroid invasion assay were performed to assess the effects of C/EBPα on migration and invasion in lung adenocarcinoma cells in vitro. Western blotting was applied to analyze the potential mechanisms. Results: C/EBPα was found to be decreased in lung adenocarcinoma tissues compared to para-carcinoma tissues. Overexpression of C/EBPα significantly inhibited the migration and invasion of lung adenocarcinoma cells. In addition, C/EBPα overexpression suppressed the epithelial–mesenchymal transition (EMT) that was characterized by a gain of epithelial and loss of mesenchymal markers. Further study showed that C/EBPα suppressed the transcription of β-catenin and downregulated the levels of its downstream targets. Conclusion: Our data suggest that C/EBPα inhibits lung adenocarcinoma cell invasion and migration by suppressing β-catenin-mediated EMT in vitro. Thus, C/EBPα may be helpful as a potential target for treatment of lung adenocarcinoma.

scholarly journals p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells

2013 ◽  
Vol 43 (5) ◽  
pp. 1569-1577 ◽  
Author(s):  
HIROTSUGU NOTSUDA ◽  
AKIRA SAKURADA ◽  
CHIAKI ENDO ◽  
YOSHINORI OKADA ◽  
AKIRA HORII ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Invasion And Migration ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
And Migration

EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells

2012 ◽  
Vol 103 (3) ◽  
pp. 373-379 ◽  
Author(s):  
Stephan M. Huber ◽  
Milan Misovic ◽  
Claus Mayer ◽  
Hans-Peter Rodemann ◽  
Klaus Dittmann
Keyword(s):  
Lung Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
Sodium Glucose Cotransport ◽  
Human A549 ◽  
A549 Lung ◽  
Stimulation Of

scholarly journals miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4

2016 ◽  
Vol 35 (5) ◽  
pp. 2755-2766 ◽  
Author(s):  
MEI SUN ◽  
SHUNMING HONG ◽  
WENHAN LI ◽  
PENGFEI WANG ◽  
JINQIANG YOU ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Invasion And Migration ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
And Migration
Sign in / Sign up

Export Citation Format

Share Document