scholarly journals Role of Neoadjuvant Radio-chemotherapy for the Treatment of High Rectal Cancer

2018 ◽  
Vol 38 (9) ◽  
pp. 5371-5377
Author(s):  
MAXI TREDER ◽  
STEFAN JANSSEN ◽  
NIELS HENRIK HOLLÄNDER ◽  
STEVEN E. SCHILD ◽  
DIRK RADES
Keyword(s):  
Rectal Cancer ◽  
Radio Chemotherapy ◽  
Neoadjuvant Radio Chemotherapy

Surgical treatment of patients with rectal cancer following long-term neoadjuvant radio-chemotherapy

2006 ◽  
Vol 44 (05) ◽  
Author(s):  
Z Simonka ◽  
L Varga ◽  
J Hőhn ◽  
G Baradnay ◽  
T Géczi ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Surgical Treatment ◽  
Radio Chemotherapy ◽  
Neoadjuvant Radio Chemotherapy

Does A Longer Waiting Period After Neoadjuvant Radio-chemotherapy Improve the Oncological Prognosis of Rectal Cancer?

2019 ◽  
Vol 270 (5) ◽  
pp. 747-754 ◽  
Author(s):  
Jérémie H. Lefèvre ◽  
Laurent Mineur ◽  
Marine Cachanado ◽  
Quentin Denost ◽  
Philippe Rouanet ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Waiting Period ◽  
Radio Chemotherapy ◽  
Neoadjuvant Radio Chemotherapy

Time interval between neoadjuvant radio-chemotherapy and surgery in rectal cancer: is the long interval correct for all patients?

2021 ◽  
Author(s):  
Antonio Costanzo ◽  
Antonio Ghidini ◽  
Fausto Petrelli ◽  
Luca Turati ◽  
Valentina Rampulla ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Time Interval ◽  
Radio Chemotherapy ◽  
Neoadjuvant Radio Chemotherapy

The Role of MRI in Treatment Planning for Rectal Cancer - A Review

2013 ◽  
Vol 9 (2) ◽  
pp. 111-116
Author(s):  
R.K. Bott ◽  
M. Chand ◽  
G.F. Nash ◽  
R.I. Swift ◽  
G. Brown
Keyword(s):  
Rectal Cancer ◽  
Treatment Planning

scholarly journals Can Pre-Treatment Inflammatory Parameters Predict the Probability of Sphincter-Preserving Surgery in Patients with Locally Advanced Low-Lying Rectal Cancer?

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 946
Author(s):  
Richard Partl ◽  
Katarzyna Lukasiak ◽  
Bettina Stranz ◽  
Eva Hassler ◽  
Marton Magyar ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anal Verge ◽  
Locally Advanced ◽  
Multivariable Analysis ◽  
Sphincter Preservation ◽  
Independent Predictive Factor ◽  
Lymphocyte Ratio ◽  
Inflammatory Parameters ◽  
Pre Treatment

There is evidence suggesting that pre-treatment clinical parameters can predict the probability of sphincter-preserving surgery in rectal cancer; however, to date, data on the predictive role of inflammatory parameters on the sphincter-preservation rate are not available. The aim of the present cohort study was to investigate the association between inflammation-based parameters and the sphincter-preserving surgery rate in patients with low-lying locally advanced rectal cancer (LARC). A total of 848 patients with LARC undergoing radiotherapy from 2004 to 2019 were retrospectively reviewed in order to identify patients with rectal cancer localized ≤ 6 cm from the anal verge, treated with neo-adjuvant radiochemotherapy (nRCT) and subsequent surgery. Univariable and multivariable analyses were used to investigate the role of pre-treatment inflammatory parameters, including the C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the prediction of sphincter preservation. A total of 363 patients met the inclusion criteria; among them, 210 patients (57.9%) underwent sphincter-preserving surgery, and in 153 patients (42.1%), an abdominoperineal rectum resection was performed. Univariable analysis showed a significant association of the pre-treatment CRP value (OR = 2.548, 95% CI: 1.584–4.097, p < 0.001) with sphincter preservation, whereas the pre-treatment NLR (OR = 1.098, 95% CI: 0.976–1.235, p = 0.120) and PLR (OR = 1.002, 95% CI: 1.000–1.005, p = 0.062) were not significantly associated with the type of surgery. In multivariable analysis, the pre-treatment CRP value (OR = 2.544; 95% CI: 1.314–4.926; p = 0.006) was identified as an independent predictive factor for sphincter-preserving surgery. The findings of the present study suggest that the pre-treatment CRP value represents an independent parameter predicting the probability of sphincter-preserving surgery in patients with low-lying LARC.

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