scholarly journals Down-regulation of Toll-like Receptor TLR4 Ιs Associated with HPV DNA Integration in Penile Carcinoma

2017 ◽  
Vol 37 (10) ◽  
Keyword(s):  
Penile Carcinoma ◽  
Toll Like Receptor ◽  
Down Regulation ◽  
Dna Integration ◽  
Hpv Dna

HPV-DNA-Integration in Oropharynxkarzinomen

2004 ◽  
Vol 83 (02) ◽  
Author(s):  
JP Klussmann ◽  
S Dinh ◽  
C Wittekindt ◽  
L Turek ◽  
E Smith ◽  
...  
Keyword(s):  
Dna Integration ◽  
Hpv Dna

Hypothetical Genes Are Frequent Targets of HPV DNA Integration in Cervical Carcinomas

2005 ◽  
Vol 127 (04) ◽  
Author(s):  
T Koch ◽  
I Kraus ◽  
C Ziegert ◽  
A Schneider ◽  
M Dürst
Keyword(s):  
Dna Integration ◽  
Hpv Dna ◽  
Cervical Carcinomas ◽  
Hypothetical Genes

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype

2012 ◽  
Vol 447 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Ming-Huei Chou ◽  
Ying-Hsien Huang ◽  
Tsun-Mei Lin ◽  
Yung-Ying Du ◽  
Po-Chin Tsai ◽  
...  
Keyword(s):  
Liver Injury ◽  
Obstructive Jaundice ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Toll Like Receptor ◽  
Selective Activation ◽  
Down Regulation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury ◽  
Tgf Β1

Cholestatic liver injury may activate HSCs (hepatic stellate cells) to a profibrogenic phenotype, contributing to liver fibrogenesis. We have previously demonstrated the involvement of TLR (Toll-like receptor) 7 in the pathogenesis of biliary atresia. In the present study we investigated the ability of TLR7 to modulate the profibrogenic phenotype in HSCs. Obstructive jaundice was associated with significant down-regulation of TLR7. Primary HSCs isolated from BDL (bile duct ligation) rats with obstructive jaundice exhibited reduced expression of TLR7 and increased expression of α-SMA (α-smooth muscle actin) and collagen-α1 compared with sham rats, reflecting HSC-mediated changes. Treatment of primary activated rat HSCs and rat T6 cells with CL075, a TLR7 and TLR8 ligand, significantly decreased expression of MCP-1 (monocyte chemotactic protein-1), TGF-β1 (transforming growth factor-β1), collagen-α1 and MMP-2 (matrix metalloproteinase-2), and inhibited cell proliferation and migration. In contrast, silencing TLR7 expression with shRNA (short hairpin RNA) in T6 cells effectively blocked the effects of CL075 stimulation, reversing the changes in MCP-1, TGF-β1 and collagen-α1 expression and accelerating cell migration. Our results indicate that obstructive jaundice is associated with down-regulation of TLR7 and up-regulation of profibrogenic gene expression in HSCs. Selective activation of TLR7 may modulate the profibrogenic phenotype in activated HSCs associated with cholestatic liver injury.

The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4

2010 ◽  
Vol 38 (5) ◽  
pp. 3037-3044 ◽  
Author(s):  
Jun Yang ◽  
Xiao-Dong Zhang ◽  
Jian Yang ◽  
Jia-Wang Ding ◽  
Zhao-Qi Liu ◽  
...  
Keyword(s):  
Ischemic Injury ◽  
Cardioprotective Effect ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Down Regulation
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