Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer

2016 ◽  
Vol 36 (12) ◽  
pp. 6319-6326 ◽  
Author(s):  
TSUKIHISA YOSHIDA ◽  
TATSURO OKAMOTO ◽  
TOKUJIRO YANO ◽  
KAZUKI TAKADA ◽  
MIKIHIRO KOHNO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Histological Type ◽  
Small Cell Lung ◽  
Factors Associated

scholarly journals Dose-volume parameters predict radiation pneumonitis after induction chemoradiotherapy followed by surgery for non-small cell lung cancer: a retrospective analysis

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kuniaki Katsui ◽  
Takeshi Ogata ◽  
Kenta Watanabe ◽  
Norihisa Katayama ◽  
Junichi Soh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Radiation Pneumonitis ◽  
Lower Lobe ◽  
Small Cell ◽  
Lung Dose ◽  
Small Cell Lung ◽  
Factors Associated ◽  
Dose Volume

Abstract Background The relationship between lung dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) associated with induction concurrent chemoradiotherapy (CCRT) followed by surgery in patients with non-small cell lung cancer (NSCLC) is unclear, particularly when concerning irradiation of the whole lung prior to resection. We performed this study to identify factors associated with grade ≥ 2 RP in such patients. Methods Patients who received induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 46 Gy/23 fractions) between May 2003 and May 2017 were reviewed. The mean lung dose (MLD) and the percentage of the lung volume that received ≥5 Gy (V5) and ≥ 20 Gy (V20) were calculated. Factors associated with the development of grade ≥ 2 RP were analyzed. Results One hundred and eight patients were included in this study, 34 (31.5%) of whom experienced grade ≥ 2 RP. A V20 ≥ 21%, an MLD ≥10 Gy, and a lower lobe tumor location were significant predictors of grade ≥ 2 RP on univariate analysis (p = 0.007, 0.002, and 0.004, respectively). Moreover, an MLD ≥10 Gy and lower lobe location were significant predictors of grade ≥ 2 RP on multivariate analysis (p = 0.026 and 0.0043, respectively). The cumulative incidence rates of grade ≥ 2 RP at 6 months were 15.7 and 45.6% in patients with MLDs < 10 Gy and ≥ 10 Gy, respectively, and were 23.5 and 55.6% in patients with upper/middle lobe- vs. lower lobe-located tumors, respectively. Conclusions MLD and lower lobe location were predictors of grade ≥ 2 RP in patients who received induction CCRT. It is necessary to reduce the MLD to the greatest extent possible to prevent the occurrence of this adverse event.

Socioeconomic Factors Associated with Lack of Treatment in Early Stage Non-Small Cell Lung Cancer

2019 ◽  
Vol 37 (9) ◽  
pp. 506-511
Author(s):  
Shraddha M. Dalwadi ◽  
Jun Zhang ◽  
Eric H. Bernicker ◽  
E. Brian Butler ◽  
Bin S. Teh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Socioeconomic Factors ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Factors Associated

scholarly journals Disturbance of Respiratory Function Depends on Smoking History and Histological Type in Non-small Cell Lung Cancer

Haigan ◽  
2004 ◽  
Vol 44 (4) ◽  
pp. 219-224
Author(s):  
Hiroshi Kimura ◽  
Yuichi Takiguchi ◽  
Naoaki Sugimoto ◽  
Kazuya Fukuoka ◽  
Hiroshi Miyazawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Respiratory Function ◽  
Small Cell ◽  
Histological Type ◽  
Smoking History ◽  
Small Cell Lung

Factors associated with long-term survival of patients with advanced non-small cell lung cancer

Respirology ◽  
2011 ◽  
Vol 17 (1) ◽  
pp. 134-142 ◽  
Author(s):  
ETIENNE GIROUX LEPRIEUR ◽  
ARMELLE LAVOLE ◽  
ANNE-MARIE RUPPERT ◽  
VALéRIE GOUNANT ◽  
MARIE WISLEZ ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Term Survival ◽  
Long Term Survival ◽  
Factors Associated
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