scholarly journals Long Noncoding RNA snaR Regulates Proliferation, Migration and Invasion of Triple-negative Breast Cancer Cells

2016 ◽  
Vol 36 (12) ◽  
pp. 6289-6296 ◽  
Author(s):  
JEEYEON LEE ◽  
JIN HYANG JUNG ◽  
YEE SOO CHAE ◽  
HO YONG PARK ◽  
WAN WOOK KIM ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Migration And Invasion

scholarly journals Overexpression of MiR-146a-5p Upregulates lncRNA HOTAIR in Triple-Negative Breast Cancer Cells and Predicts Poor Prognosis

2019 ◽  
Vol 18 ◽  
pp. 153303381988294 ◽  
Author(s):  
Hongguang Liang ◽  
Weihua Huang ◽  
Yuandong Wang ◽  
Lingying Ding ◽  
Lixian Zeng
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Noncoding Rna ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Invasion And Migration ◽  
Tumor Tissues ◽  
Regulatory Effects

MiR-146a-5p plays different roles in different types of cancers. We showed that miR-146a-5p and long noncoding RNA HOTAIR were both upregulated in triple-negative breast cancer. Follow-up study showed that high levels of miR-146a-5p and HOTAIR in tumor tissues were closely correlated with poor survival. MiR-146a-5p and HOTAIR were positively correlated in tumor tissues. MiR-146a-5p positively regulated HOTAIR triple-negative breast cancer cells, while HOTAIR showed no regulatory effects on miR-146a-5p expression. MiR-146a-5p and HOTAIR positively regulated the migration and invasion of triple-negative breast cancer cells. In addition, HOTAIR silencing attenuated the effects of miR-146a-5p. Therefore, overexpression of miR-146a-5p may promote triple-negative breast cancer cell invasion and migration by upregulating HOTAIR.

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