scholarly journals Runt-related Transcription Factor 1 (RUNX1T1) Suppresses Colorectal Cancer Cells Through Regulation of Cell Proliferation and Chemotherapeutic Drug Resistance

2016 ◽  
Vol 36 (10) ◽  
pp. 5257-5264 ◽  
Author(s):  
MUSAAD ALFAYEZ ◽  
RADHAKRISHNAN VISHNUBALAJI ◽  
NEHAD M ALAJEZ
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Drug Resistance ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Chemotherapeutic Drug ◽  
Colorectal Cancer Cells ◽  
Related Transcription Factor ◽  
Transcription Factor 1

scholarly journals Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Miran Rada ◽  
Audrey Kapelanski-Lamoureux ◽  
Stephanie Petrillo ◽  
Sébastien Tabariès ◽  
Peter Siegel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Patterns ◽  
Colorectal Cancer Liver Metastases ◽  
Related Transcription Factor ◽  
Transcription Factor 1

AbstractColorectal cancer liver metastasis (CRCLM) has two major histopathological growth patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement lesions obtain their blood supply through vessel co-option, wherein the cancer cells hijack pre-existing blood vessels of the surrounding liver tissue. Consequentially, anti-angiogenic therapies are less efficacious in CRCLM patients with replacement lesions. However, the mechanisms which drive vessel co-option in the replacement lesions are unknown. Here, we show that Runt Related Transcription Factor-1 (RUNX1) overexpression in the cancer cells of the replacement lesions drives cancer cell motility via ARP2/3 to achieve vessel co-option. Furthermore, overexpression of RUNX1 in the cancer cells is mediated by Transforming Growth Factor Beta-1 (TGFβ1) and thrombospondin 1 (TSP1). Importantly, RUNX1 knockdown impaired the metastatic capability of colorectal cancer cells in vivo and induced the development of angiogenic lesions in liver. Our results confirm that RUNX1 may be a potential target to overcome vessel co-option in CRCLM.

scholarly journals MSH2 is required for cell proliferation, cell cycle control and cell invasiveness in colorectal cancer cells

2012 ◽  
Vol 57 (20) ◽  
pp. 2580-2585
Author(s):  
Kai Shen ◽  
YingJiang Ye ◽  
KeWei Jiang ◽  
Bin Liang ◽  
XiaoDong Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Cell Cycle Control ◽  
Colorectal Cancer Cells ◽  
Cell Invasiveness
Sign in / Sign up

Export Citation Format

Share Document