scholarly journals Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance

2016 ◽  
Vol 36 (10) ◽  
pp. 5153-5162 ◽  
Author(s):  
SHUHEI SUZUKI ◽  
MASASHI OKADA ◽  
KENTA KURAMOTO ◽  
HIROYUKI TAKEDA ◽  
HIROTSUGU SAKAKI ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Dopamine Agonist ◽  
Partial Dopamine Agonist

Cancer stem cells in pancreaticobiliary tumors

2019 ◽  
Author(s):  
J Gogolok ◽  
E Seidel ◽  
A Strönisch ◽  
A Reutzel-Selke ◽  
A Andreou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells

Cancer stem cells obtained from normal brain stem cells

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
FA Siebzehnrubl ◽  
I Jeske ◽  
D Müller ◽  
M Hildebrandt ◽  
E Hahnen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Brain Stem ◽  
Normal Brain

Antitumoral effects of metformin on cancer stem cells: identification of novel molecular targets

2014 ◽  
Author(s):  
Roberto Wurth ◽  
Marta Gritti ◽  
Marina Angelini ◽  
Federica Barbieri ◽  
Michele Mazzanti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Molecular Targets

CD133/CD166/Ki-67 Triple Immunouorescence Assessment for Putative Cancer Stem Cells in Colon Carcinoma*

2014 ◽  
Vol 23 (2) ◽  
pp. 161-170 ◽  
Author(s):  
Claudiu Margaritescu ◽  
Daniel Pirici ◽  
Irina Cherciu ◽  
Alexandru Barbalan ◽  
Tatiana Cârtâna ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Colon Carcinoma ◽  
Sodium Dodecyl ◽  
High Grade Dysplasia ◽  
Early Event ◽  
Low Grade ◽  
High Grade

Background & Aims: Colorectal cancer represents the third most common malignancy and the fourth most common cause of cancer death worldwide. The existence of drug-resistant colon cancer stem cells is thought to be one of the most important reasons behind treatment failure in colon cancer, their existence putatively leading to metastasis and recurrences. The aim of our study was to investigate the immunoexpression patterns of CD133 and CD166 in colon carcinoma, both individually and in combination, assessing their significance as prognostic markers.Methods. A total of 45 retrospective colon adenocarcinoma cases were investigated by enzymatic and multiple fluorescence immunohistochemistry for their CD133 and CD166 expression and colocalization.Results. Both CD133 and CD166 were expressed to different extents in all cancer specimens, with apredominant cytoplasmic pattern for CD133 and a more obvious membranous-like pattern for CD166.Overall, when comparing their reactivity for the tumoral tissue, CD166 expression areas seemed to be smaller than those of CD133. However, there was a direct correlation between CD133 and CD166 expression levels throughout the entire spectrum of lesions, with higher values for dysplastic lesions. Colocalization of CD133/ CD166 was obvious at the level of cells membranes, with higher coeficients in high grade dysplasia, followed by well and moderate differentiated tumours.Conclusions. CD133/CD166 colocalization is an early event occurring in colon tumorigenesis, with thehighest coeficients recorded for patients with high grade dysplasia, followed by well differentiated tumours. Thus, we consider that the coexpression of these two markers could be useful for further prognostic andtherapeutically stratification of patients with colon cancer.Abbreviations: AJCC - American Joint Committee on Cancer; CCD - charge-coupled device camera sensor; CD133 - prominin-1 (PROM1); CD166 - Activated Leukocyte Cell Adhesion Molecule (ALCAM); CRC - colorectal cancer; CSC - cancer stem cells; DAB - 3,3'-diaminobenzidine chromogen; DAPI - 4',6-diamidino- 2-phenylindole; HE - Hematoxylin and eosin staining; HGD - high grade dysplasia; HRP - horseradish peroxidase; LGD - low grade dysplasia; SDS - sodium dodecyl sulfate*Part of this work has been accepted as a poster presentation at the Digestive Disease Week (DDW) meeting, Chicago, IL, USA May 3-6, 2014

NORMAL AND CANCER STEM CELLS: DISCOVERY, DIAGNOSIS AND THERAPY INTERNATIONAL SCIENTIFIC CONFERENCE

2017 ◽  
Vol 39 (3) ◽  
pp. 234-256
Author(s):  
Editorial Board
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Scientific Conference ◽  
National Academy Of Sciences ◽  
Experimental Pathology ◽  
Diagnosis And Therapy ◽  
Academy Of Sciences

NORMAL AND CANCER STEM CELLS: DISCOVERY, DIAGNOSIS AND THERAPY INTERNATIONAL SCIENTIFIC CONFERENCE R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv October 5–6, 2017

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