Surface Modification Enhances Osteoblast Behavior and Bone Formation on Thin Hydroxyapatite Layers Deposited Using a Novel Anodization-Hydrothermal Treatment on Commercially Pure Titanium Endosseous Implants

2008 ◽  
Vol 7 (2) ◽  
pp. 159-161 ◽  
Author(s):  
Jun Takebe ◽  
Yoshihiro Nakasato ◽  
Shigeki Ito ◽  
Seiichiro Kikuchi ◽  
Sozo Itoh ◽  
...  
Keyword(s):  
Surface Modification ◽  
Bone Formation ◽  
Hydrothermal Treatment ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Endosseous Implants ◽  
Commercially Pure

Histological and Histomorphometric Studies of the Effects of Hyaluronic Acid on Osseointegration of Titanium Implant in Rabbits

2018 ◽  
Vol 30 (2) ◽  
pp. 10-16
Author(s):  
Mohammad Hasan Mohammad ◽  
Nada M. H. Al-Ghaban
Keyword(s):  
Hyaluronic Acid ◽  
Bone Formation ◽  
Healing Process ◽  
Pure Titanium ◽  
Titanium Implant ◽  
Commercially Pure Titanium ◽  
Histomorphometric Analysis ◽  
Natural Polymers ◽  
Commercially Pure ◽  
Significant Difference

Background: One of the unique prosthesis for tooth or teeth replacement is the dental implant. Our attempt is using a biomaterial system that is easily obtained and applicable and has the ability to provoke osteoinductive growth factor to enhance bone formation at the site of application. One of these natural polymers is hyaluronic acid. Material and methods: Sixty machined surface implants from commercially pure titanium rod inserted in thirty NewZealand rabbits. Two implants placed in both tibia of each rabbit. The animals scarified at 1, 2 and 4 weeks after implantation (10 rabbits for each interval). For all of animals the right tibia’s implant was control (uncoated) and the left one was experimental (coated with 0.1ml Hyaluronic acid gel). All sections have been stained with Haematoxylin and Eosin then they were histologically examined and assessed for histomorphometric analysis for counting of bone cells (osteoblast, osteocyte and osteoclast), cortical bone thickness, trabecular width, thread width and marrow space star volume (V*). Results: Histological findings for hyaluronic acid- coated titanium implant revealed an earlier bone formation, mineralization and maturation than that in control groups. Histomorphometric analysis for all bone parameters that examined in this study, showed highly significant difference between control and experimental groups in all healing intervals. Conclusion: Commercially pure titanium endosseous implants coated with hyaluronic acid may be osteocoductive thus accelerating healing process and enhancing osseointegration.

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