scholarly journals Study of the Association Between Antihyperglycemic Therapy and Cancer in Patients with Type 2 Diabetes Mellitus

2020 ◽  
Vol 27 (3) ◽  
pp. E202033
Author(s):  
Tamara Vatseba ◽  
Liubov Sokolova ◽  
Volodymyr Pushkarev ◽  
Nataliia Koshel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Confidence Interval ◽  
Insulin Therapy ◽  
Odds Ratio ◽  
Antidiabetic Therapy ◽  
Antihyperglycemic Therapy ◽  
Risk Of Cancer

The objective of the research was to investigate the features and association of antihyperglycemic therapy and cancer in patients with type 2 diabetes mellitus. Materials and Methods. The study included the analysis of medical records of patients with type 2 diabetes mellitus who were diagnosed with cancer during 2012-2016. The obtained results were processed by statistical methods using the software packages Microsoft Excel and Statistika-12. The significance of differences between the frequency of using different treatment schemes was assessed by the Pearson’s test (χ²). To determine the risk of predicted events, the odds ratio, the 95% confidence interval, the positive and negative prognostic values were calculated. Results. There were diagnosed 533 cases of cancer in patients with type 2 diabetes mellitus. The most common scheme of antihyperglycemic therapy prior to the detection of malignant diseases was a combination of metformin and sulfonylurea derivatives (35.65%), as well as monotherapy with sulfonylurea derivatives (17.26%) and metformin (11.28%). Prior to diagnosing cancer in 396 (74.30%) patients, antihyperglycemic therapyalong with sulfonylurea derivatives and insulin was used. Among obese patients 68.82% used sulfonylureas and insulin as part of antidiabetic therapy before diagnosis of cancer. The connection between insulin therapy and the risk of cancer development in patients with type 2 diabetes mellitus was proved (the odds ratio=2.35; the 95% confidence interval (1.91 - 2.91); p<0.001). Conclusions. Prior to the detection of cancer in patients with type 2 diabetes mellitus, the combination therapy with metformin and sulfonylurea derivatives was most often used. The association between insulin therapy and the development of cancer in patients with type 2 diabetes mellitus was revealed. Cancer screening is advisable for patients with type 2 diabetes mellitus and obesity, who receive as a therapy sulfonylurea derivates and/or insulin.

scholarly journals Glycemic control and its determinants among patients with type 2 diabetes mellitus at Menelik II Referral Hospital, Ethiopia

2021 ◽  
Vol 9 ◽  
pp. 205031212110230
Author(s):  
Tadesse Alemu ◽  
Tirhas Tadesse ◽  
Getasew Amogne
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Poor Glycemic Control ◽  
Diabetic Patients

Objective: The objective of the study was to explore the level of glycemic control and its determinants among patients with type 2 diabetes mellitus at Menelik II Referral Hospital, Addis Ababa, Ethiopia. Methods: Cross-sectional study design was employed. The sample size was determined using a single proportion formula and 245 patients with type 2 diabetes mellitus were involved in this study. Systematic sampling method was used to select the study subjects. Standard questionnaire was used to collect patient’s biographic data, economic data, self-care activities, and patient compliance to medications. Summary statistics of a given data were calculated. Logistic regression model was used to measure the relationship between the outcome and predictor variable. Direction and strength of association was expressed using odds ratio and 95% confidence interval. Result: More than three-fourth, 191 (80.3%) of diabetic patients had poor glycemic control. Poor glycemic control was found to be 7.03 times higher among diabetic patients with duration of 5–10 years (adjusted odds ratio = 7.03, 95% confidence interval = 2.7–18.6). Similarly, diabetic patients with a duration of above 10 years were poorly controlled their blood sugar level (adjusted odds ratio = 2.3, 95% confidence interval = 1.028–5.08) in comparison to diabetic patients with a duration of fewer than 5 years. It was also found that compliance with a specific diet was significantly associated with good control of blood sugar level (adjusted odds ratio = 3.7, 95% confidence interval = 1.24–11.13). Conclusion: The magnitude of patients with poor glycemic control was high. Duration of diabetes and non-compliance with diets high in fruits, vegetables, and diets low in fat and sugar were significantly related to uncontrolled blood glucose levels. Therefore, developing strategies targeted toward improving blood glucose control with special attention to diabetes mellitus (DM) patients with a duration of ⩾5 years and those who poorly comply with their diet was strongly recommended.

scholarly journals Self-monitoring practice in patients with type 2 diabetes mellitus: data from regional mobile diabetes centre

2012 ◽  
Vol 15 (2) ◽  
pp. 32-37 ◽  
Author(s):  
Alexander Vladimirovich Petrov ◽  
Alena Alexandrovna Kalinnikova ◽  
Lyudmila Alexandrovna Suvorova ◽  
Leonid Grigor'evich Strongin ◽  
Daria Vladimirovna Logutova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Self Monitoring ◽  
Oral Agents ◽  
Laboratory Test Results ◽  
Antihyperglycemic Therapy ◽  
Hba1c Levels

Aims. To determine popularity and variants of blood glucose self-monitoring in patients with type 2 diabetes mellitus (T2DM) as wellas its correlation with efficiency of antihyperglycemic therapy. Materials and methods. Current study was carried out within the framework of mobile diabetes centre project. We analyzed 545 patients,assessing their clinical status, laboratory test results (including HbA1c levels) and self-monitoring frequency. Results. 49% of patients reported regular self-monitoring, while 25% conducted monitoring of both fasting and postprandial bloodglucose levels. Percentage of patients performing self-monitoring was found to be independent of age and length of diabetes experience,but correlated with insulin therapy and rating of chronic diabetic complications. Self-monitoring was associated with lower rate ofdiabetic decompensation and was much more common among patients on insulin therapy, being associated with statistically significantreduction of HbA1c levels. Conclusion. Self-monitoring is associated with greater efficiency of antihyperglycemic treatment in patients with T2DM on insulintherapy, as well as in those receiving oral agents only.

Efficacy and Safety of Continuing Sitagliptin when Initiating Insulin Therapy in Subjects with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 112-LB ◽  
Author(s):  
RONAN ROUSSEL ◽  
SANTIAGO DURAN-GARCIA ◽  
YILONG ZHANG ◽  
SUNERI SHAH ◽  
CAROLYN DARMIENTO ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Efficacy And Safety
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