scholarly journals The Effect of Single Use of Sorbilact and Its Combination with L-Arginine on the State of the Cardiovascular System in Endogenous Intoxication Syndrome of Purulent-Septic Genesis

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Natalya Maksymchuk ◽  
Viktor Konovchuk
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Cardiovascular System ◽  
Standard Therapy ◽  
Specific Effect ◽  
Left Ventricular ◽  
Systemic Inflammatory Response ◽  
Septic Complications ◽  
Endogenous Intoxication ◽  
Group I

The preparations of polyhydric alcohols, namely sorbitol-based ones, and their combination with adjuvant therapy, namely L-arginine are sufficiently promising for treatment of purulent-septic complications. The systemic nature of their action makes it appropriate to carry out studies of specific effect on the circulatory system, since their wide homeostatic and pharmacodynamic spectrum is beyond doubt for other systems and organs within the “efficiency-safety” algorithm.The objective of the research was to study the effect of combined use of sorbilact and L-arginine on the cardiovascular system of patients with endogenous intoxication syndrome during the period of developing early secondary autoaggression.Materials and methods. The study included 117 patients who were divided into the following groups: Group I consisted of 31 patients with systemic inflammatory response syndrome; Group II included 27 patients with endogenous intoxication syndrome treated according to 2016 Surviving Sepsis Campaign; Group ІІI comprised 29 patients with endogenous intoxication syndrome who received sorbilact in addition to standard therapy; Group IV included 30 patients with systemic inflammatory response syndrome who received standard therapy as well as sorbilact and L-arginine.Results. Co-administration of sorbilact and L-arginine was accompanied by an increase in stroke volume and cardiac output, activation of left ventricular minute work alongside with a moderate decrease in mean arterial pressure and systemic vascular resistance.Conclusions. The application of sorbilact and L-arginine in patients with endogenous intoxication syndrome provides hemodynamic stability.

scholarly journals Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome

Blood ◽  
1994 ◽  
Vol 83 (5) ◽  
pp. 1398-1407 ◽  
Author(s):  
HH Simms ◽  
R D'Amico
Keyword(s):  
Acute Pancreatitis ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Pertussis Toxin ◽  
Whole Blood ◽  
Systemic Inflammatory Response ◽  
Matrix Proteins ◽  
H2o2 Production ◽  
Group Iii ◽  
Group I

Abstract Altered polymorphonuclear leukocyte (PMN) function is thought to contribute to organ dysfunction during the systemic inflammatory response syndrome (SIRS). To test this hypothesis, we evaluated whole blood PMN function adherent to fibronectin or laminin in patients with mild or severe acute pancreatitis as a paradigm for sirs. Whole-blood PMN intracellular H2O2 production, expression of CD32w (Fc gamma R II), CD16 (Fc gamma R III), and phagocytosis were performed using dichlorofluorescein diacetate, fluorescein isothiocyanate-labeled anti- CD32w, CD16, and serum-opsonized fluorescent microspheres. Group I (n x 7) represents normal control individuals; group II (n x 11) represents patients with mild acute pancreatitis. Group III (n x 15) represents critically ill patients with severe acute pancreatitis. Adherence of PMN from groups I and II to matrix proteins resulted in a 5% to 20% increase in each PMN function assayed whereas adherence of PMN from group III to matrix proteins resulted in 50% to 75% increases in each PMN function assayed. Pertussis toxin, pentoxifylline, and dibutyryl cyclic adenosine monophosphate (cAMP) each reduced group I-II H2O2 production and phagocytosis. Pentoxifylline and dibutyryl cAMP but not pertussis toxin reduced group III H2O2 production. Both intracellular H2O2 and phagocytosis assays from group III but not groups I-II showed exaggerated upregulation when exposed to NaF (4 mmol/L). Anti- interleukin-6 reduced the increase in intracellular H2O2 production in group III patients and significantly altered the exaggerated oxidative response to NaF. Longitudinal studies of group III whole-blood PMN showed persistent upregulation of intracellular H2O2 production in those patients whose hospital courses were complicated by multiple system organ failure. These results demonstrate abnormal whole blood PMN function during the systemic inflammatory response syndrome in the presence of fibronectin, or laminin and that this is mediated in part via a pertussis toxin insensitive altered guanosine triphosphate- binding protein.

scholarly journals Clinical and laboratory characteristics of the postoperative period in patients with maxillofacial phlegmon

2018 ◽  
Vol 22 (4) ◽  
pp. 634-639
Author(s):  
P. V. Belyaev ◽  
E. I. Shtatko ◽  
A. A. Viltsanyuk
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Postoperative Period ◽  
Elevated Level ◽  
Systemic Inflammatory Response ◽  
Blood Protein ◽  
Average Weight ◽  
Upper Limit ◽  
Endogenous Intoxication ◽  
Definition Of

The problem of treatment of purulent-inflammatory diseases of the maxillofacial area remains one of the most pressing problems of modern dentistry. The aim of the work is to conduct a clinical and laboratory analysis of the postoperative period in patients operated on for odontogenic phlegmon of the maxillofacial area. 39 patients with odontogenic phlegmons of the maxillofacial area were examined. All patients before surgery, in the postoperative period for 3, 5, 7, 10 days and before discharge, conducted laboratory tests with the definition of a general analysis of blood and urine, the total amount of protein, sugar, urea and creatinine. Serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) were determined by ELISA with the definition of IMMUNOTECH kits (France) and IMTEK kits (Russia). Endogenous intoxication was determined by the level of molecules of average weight in the blood, leukocyte index and hematological index of intoxication. The obtained data were processed statistically and compared at different periods of observation. During hospitalization in all patients, inflammatory process, severe endogenous intoxication, and systemic inflammatory response syndrome were expressed. In the postoperative period, patients significantly (p<0.05) reduced the total amount of blood protein, erythrocytes, hemoglobin, which a day before discharge were significantly lower (p<0.05) compared with the time of hospitalization. The number of leukocytes, the level of urea and creatinine also decreased before discharge, their indicator was at the level of the upper limit of normal. Up to 5 days after surgery, an elevated level of average weight molecules was established with a gradual reliable (p<0.05) decrease of this indicator to the upper limit of normal before discharge. Up to 5 days after surgery, an elevated level of average weight molecules has been established with a gradual reliable (p<0.05) decrease of this indicator to the upper limit of normal before discharge. In the first 5 days after the start of treatment, there was a significant (p<0.05) increase in the level of CRP¸ TNF-α and IL-6, whose level was normalized before discharge. Clinical and laboratory characteristics of the postoperative period in patients operated on for phlegmon of the maxillofacial region indicates that the severity of the course is due to the development of the systemic inflammatory response syndrome and endogenous intoxication.

scholarly journals Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome

Blood ◽  
1994 ◽  
Vol 83 (5) ◽  
pp. 1398-1407 ◽  
Author(s):  
HH Simms ◽  
R D'Amico
Keyword(s):  
Acute Pancreatitis ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Pertussis Toxin ◽  
Whole Blood ◽  
Systemic Inflammatory Response ◽  
Matrix Proteins ◽  
H2o2 Production ◽  
Group Iii ◽  
Group I

Altered polymorphonuclear leukocyte (PMN) function is thought to contribute to organ dysfunction during the systemic inflammatory response syndrome (SIRS). To test this hypothesis, we evaluated whole blood PMN function adherent to fibronectin or laminin in patients with mild or severe acute pancreatitis as a paradigm for sirs. Whole-blood PMN intracellular H2O2 production, expression of CD32w (Fc gamma R II), CD16 (Fc gamma R III), and phagocytosis were performed using dichlorofluorescein diacetate, fluorescein isothiocyanate-labeled anti- CD32w, CD16, and serum-opsonized fluorescent microspheres. Group I (n x 7) represents normal control individuals; group II (n x 11) represents patients with mild acute pancreatitis. Group III (n x 15) represents critically ill patients with severe acute pancreatitis. Adherence of PMN from groups I and II to matrix proteins resulted in a 5% to 20% increase in each PMN function assayed whereas adherence of PMN from group III to matrix proteins resulted in 50% to 75% increases in each PMN function assayed. Pertussis toxin, pentoxifylline, and dibutyryl cyclic adenosine monophosphate (cAMP) each reduced group I-II H2O2 production and phagocytosis. Pentoxifylline and dibutyryl cAMP but not pertussis toxin reduced group III H2O2 production. Both intracellular H2O2 and phagocytosis assays from group III but not groups I-II showed exaggerated upregulation when exposed to NaF (4 mmol/L). Anti- interleukin-6 reduced the increase in intracellular H2O2 production in group III patients and significantly altered the exaggerated oxidative response to NaF. Longitudinal studies of group III whole-blood PMN showed persistent upregulation of intracellular H2O2 production in those patients whose hospital courses were complicated by multiple system organ failure. These results demonstrate abnormal whole blood PMN function during the systemic inflammatory response syndrome in the presence of fibronectin, or laminin and that this is mediated in part via a pertussis toxin insensitive altered guanosine triphosphate- binding protein.

Systemic inflammatory response syndrome after major abdominal surgery

2019 ◽  
pp. 113-116
Author(s):  
Abdullah AlSomali ◽  
Abdullah Mobarki ◽  
Mohammed Almuhanna ◽  
Abdullah Alqahtani ◽  
Ziyad Alhawali ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Abdominal Surgery ◽  
Systemic Inflammatory Response ◽  
Major Abdominal Surgery
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