scholarly journals Quality of Life as an Integrative Indicator of Health Status in Patients with Chronic Hepatitis C and Concomitant Diabetes Mellitus Type II

2016 ◽  
Vol 22 (2) ◽  
pp. 201625
Author(s):  
Oleksandra Marynchak ◽  
Oleksandra Pryshliak ◽  
Oksana Kopchak ◽  
Iryna Hrynchyshyn ◽  
Ludmyla Byderkevych

The main indicators of quality of life in patients with chronic hepatitis C with concomitant diabetes mellitus type II were studied on the basis of SF-36. A sharp decrease in physical and mental health was observed in patients with combined comorbidity in comparison with the group of patients without concomitant diabetes mellitus type II. Improvement of the patients’ quality of life by all parameters was detected under the influence of alpha-lipoic acid and lactulose use in addition to antiviral therapy.

2016 ◽  
Vol 23 (4) ◽  
pp. 2016415
Author(s):  
Oleksandra Marynchak ◽  
Oleksandra Pryshliak ◽  
Oleksandr Boichuk ◽  
Olga Prokofieva

Imbalance of pro-inflammatory and anti-inflammatory cytokines was detected in 104 examined the patients with chronic hepatitis C. These changes were the most significant in patients with concomitant diabetes mellitus (DM) type II. Achievement of sustained viral response (SVR) under the influence of antiviral therapy depends on the state of cytokines system. This was evidenced by the detected correlation relationship between the levels of viral load (VL) in patients with concomitant diabetes mellitus type II, namely, direct weak one between IL-4 and VL (r=0.21) and reverse weak one between the level of IL-2 and VL (r=-0.04). Virus elimination rate and frequency influenced by anti-viral therapy (AVT) depends on the balance of pro-inflammatory and anti-inflammatory cytokines. This was shown in the research by detection of direct medium correlation relationship between VL and IL-4 (r= 0.31) and reverse medium correlation relationship between VL and IL-2 (r= -0.45).


2010 ◽  
Vol 28 ◽  
pp. e287
Author(s):  
V Katsi ◽  
D Tsartsalis ◽  
I Skiadas ◽  
K Kontoangelos ◽  
E Dragioti ◽  
...  

2008 ◽  
Vol 28 (4) ◽  
pp. 477-485 ◽  
Author(s):  
Patrick Marcellin ◽  
George K. K. Lau ◽  
Stefan Zeuzem ◽  
E. Jenny Heathcote ◽  
Paul J. Pockros ◽  
...  

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 454-454 ◽  
Author(s):  
M VONWAGNER ◽  
J LEE ◽  
R FRIEDL ◽  
B KRONENBERGER ◽  
C SARRAZIN ◽  
...  

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