scholarly journals Molecular mechanisms of salivary gland destruction in patients with Sjögren’s syndrome

2005 ◽  
Vol 28 (1) ◽  
pp. 10-20 ◽  
Author(s):  
Noriyoshi OGAWA ◽  
Kumiko SHIMOYAMA ◽  
Takafumi KAWANAMI
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Molecular Mechanisms ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals SMADS-Mediate Molecular Mechanisms in Sjögren’s Syndrome

2021 ◽  
Vol 22 (6) ◽  
pp. 3203
Author(s):  
Margherita Sisto ◽  
Domenico Ribatti ◽  
Sabrina Lisi
Keyword(s):  
Sjögren’S Syndrome ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Transforming Growth Factor ◽  
Sjögren's Syndrome ◽  
Biological Effects ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Mesenchymal Transition ◽  
Sjögren‘S Syndrome

There is considerable interest in delineating the molecular mechanisms of action of transforming growth factor-β (TGF-β), considered as central player in a plethora of human conditions, including cancer, fibrosis and autoimmune disease. TGF-β elicits its biological effects through membrane bound serine/threonine kinase receptors which transmit their signals via downstream signalling molecules, SMADs, which regulate the transcription of target genes in collaboration with various co-activators and co-repressors. Until now, therapeutic strategy for primary Sjögren’s syndrome (pSS) has been focused on inflammation, but, recently, the involvement of TGF-β/SMADs signalling has been demonstrated in pSS salivary glands (SGs) as mediator of the epithelial-mesenchymal transition (EMT) activation. Although EMT seems to cause pSS SG fibrosis, TGF-β family members have ambiguous effects on the function of pSS SGs. Based on these premises, this review highlights recent advances in unravelling the molecular basis for the multi-faceted functions of TGF-β in pSS that are dictated by orchestrations of SMADs, and describe TGF-β/SMADs value as both disease markers and/or therapeutic target for pSS.

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