scholarly journals Regulatory T cells and inflammatory bowel diseases

2004 ◽  
Vol 27 (5) ◽  
pp. 302-308 ◽  
Author(s):  
Takanori KANAI ◽  
Mamoru WATANABE
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Therapy with anti-TNFα antibody enhances number and function of Foxp3+ regulatory T cells in inflammatory bowel diseases

2011 ◽  
Vol 17 (1) ◽  
pp. 160-170 ◽  
Author(s):  
Gilles Boschetti ◽  
Stéphane Nancey ◽  
Fatima Sardi ◽  
Xavier Roblin ◽  
Bernard Flourié ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
And Function

W1803 Therapy With Anti-TNFα Antibody Enhances Number and Function of FOXP3+ Regulatory T Cells in Inflammatory Bowel Diseases

2010 ◽  
Vol 138 (5) ◽  
pp. S-743
Author(s):  
Gilles Boschetti ◽  
Fatima Sardi ◽  
Xavier Roblin ◽  
Bernard Flourie ◽  
Dominique Kaiserlian ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
And Function

scholarly journals Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

2008 ◽  
Vol 14 (10) ◽  
pp. 1521 ◽  
Author(s):  
Emilio Cuadrado ◽  
Marta Alonso ◽  
Maria Dolores de Juan ◽  
Pilar Echaniz ◽  
Juan Ignacio Arenas
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

IRF5 Acts as a Potential Therapeutic Marker in Inflammatory Bowel Diseases

2020 ◽  
Author(s):  
Yonghong Yang ◽  
Cui Zhang ◽  
Dehuai Jing ◽  
Heng He ◽  
Xiaoyu Li ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Activity ◽  
Inflammatory Bowel Diseases ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Mononuclear Cells ◽  
Orphan Receptor ◽  
Peripheral Blood Mononuclear ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Abstract Background Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic inflammatory disorders. As is well known, interferon regulatory factor (IRF) 5 is closely associated with the pathogenesis of various inflammatory diseases. But the exact role of IRF5 in IBD remains unclear. Methods In this study, we detected IRF5 expression in peripheral blood mononuclear cells (PBMCs) and inflamed mucosa from IBD patients by immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction. Peripheral blood CD4+ T cells were stimulated with inflammatory cytokines and transfected by lentivirus. Results In active IBD patients, the expression of IRF5 in PBMCs and inflamed colonic tissues was obviously increased and significantly associated with disease activity. Ectopic overexpression of IRF5 could promote the differentiation of IBD CD4+ T cells into Th1 and Th17 cells by regulating T-bet and RAR related orphan receptor C, whereas knockdown of IRF5 had the opposite effects. Tumor necrosis factor (TNF)-α upregulated expression of IRF5 in CD4+ T cells, but anti-TNF treatment with infliximab could markedly reduce IRF5 expression in CD4+ T cells and intestinal mucosa of CD patients. Conclusion Our study reveals a novel mechanism that IRF5 levels are correlated with disease activity in IBD and might function as a possible marker for the management of IBD via regulating Th1 and Th17 immune responses and cytokine production.

scholarly journals Fine tuning of the DNAM-1/TIGIT/ligand axis in mucosal T cells and its dysregulation in pediatric inflammatory bowel diseases (IBD)

2019 ◽  
Vol 12 (6) ◽  
pp. 1358-1369
Author(s):  
S. Battella ◽  
S. Oliva ◽  
L. Franchitti ◽  
R. La Scaleia ◽  
A. Soriani ◽  
...  
Keyword(s):  
T Cells ◽  
Inflammatory Bowel Diseases ◽  
Fine Tuning ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Mucosal T Cells
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