scholarly journals A young woman with rheumatoid arthritis who rapidly developed secondary amyloidosis.

1995 ◽  
Vol 18 (1) ◽  
pp. 83-89
Author(s):  
Kazuki Tanimoto ◽  
Minoru Nakamura ◽  
Kaoru Okada ◽  
Kohei Nagasawa ◽  
Yoshiyuki Niho
Keyword(s):  
Rheumatoid Arthritis ◽  
Young Woman ◽  
Secondary Amyloidosis

Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis

2009 ◽  
Vol 28 (9) ◽  
pp. 1113-1116 ◽  
Author(s):  
Hiroe Sato ◽  
Takehito Sakai ◽  
Toshiaki Sugaya ◽  
Yasuhiro Otaki ◽  
Kana Aoki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Secondary Amyloidosis ◽  
Life Threatening

scholarly journals Rituximab Therapy in Renal Amyloidosis Secondary to Rheumatoid Arthritis

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 136 ◽  
Author(s):  
Levent Kilic ◽  
Abdulsamet Erden ◽  
Yusuf Sener ◽  
Berkan Armagan ◽  
Alper Sari ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Improvement ◽  
Inflammatory Diseases ◽  
Case Series ◽  
New Drugs ◽  
Renal Amyloidosis ◽  
Secondary Amyloidosis ◽  
Aa Amyloidosis ◽  
Amyloid A ◽  
Significant Clinical Improvement

Secondary amyloid A (AA) amyloidosis is a late and serious complication of poorly controlled, chronic inflammatory diseases. Rheumatoid arthritis (RA) patients with poorly controlled, longstanding disease and those with extra-articular manifestations are under risk for the development of AA amyloidosis. Although new drugs have proven to be significantly effective in the treatment of secondary AA amyloidosis, no treatment modality has proven to be ideal. To date, only in small case series preliminary clinical improvement have been shown with rituximab therapy for AA amyloidosis secondary to RA that is refractory to TNF-α inhibitors (TNF-i) therapy. In these case series, we assessed the efficacy and safety of rituximab therapy for patients with RA and secondary amyloidosis. Hacettepe University Biologic Registry was developed at 2005. The data of the RA patients who were prescribed a biological drug were recorded regularly. Patients with biopsy proven AA amyloidosis patients were screened. Of 1022 RA patients under biologic therapy, 0.7% patients had clinically apparent histologically confirmed amyloidosis. Four of seven patients who were prescribed rituximab at least one infusion enrolled to those case series. Two of four patients showed significant clinical improvement and one of them also had decrease in proteinuria and the other one had stable renal function and proteinuria. The main goal for the treatment of AA amyloidosis is to control the activity of the underlying disorder. In this study, we showed that rituximab may be an effective treatment in RA patients with amyloidosis who were unresponsive to conventional disease modifying anti-rheumatic drugs (DMARDs) and/or TNFi.

scholarly journals Tocilizumab-induced remission of nephrotic syndrome accompanied by secondary amyloidosis and glomerulonephritis in a patient with rheumatoid arthritis

2014 ◽  
Vol 3 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Shunsuke Yamada ◽  
Akihiro Tsuchimoto ◽  
Yoshiki Kaizu ◽  
Masatomo Taniguchi ◽  
Kosuke Masutani ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Nephrotic Syndrome ◽  
Secondary Amyloidosis

Acute myocardial infarction in a young woman with rheumatoid arthritis

2015 ◽  
Vol 186 ◽  
pp. 144-145 ◽  
Author(s):  
Yong Zhang ◽  
Lijing Zhang ◽  
Xian Wang ◽  
Liang Zheng ◽  
Jie Lv ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Woman

scholarly journals SECONDARY AMYLOIDOSIS WITH LUNG INVOLVEMENT INA FEMALE PATIENT WITH RHEUMATOID ARTHRITIS

2009 ◽  
Vol 0 (3) ◽  
pp. 50
Author(s):  
Irina Mikhailovna Marusenko ◽  
Ya A Avdeyeva ◽  
I I Polskaya
Keyword(s):  
Rheumatoid Arthritis ◽  
Female Patient ◽  
Secondary Amyloidosis ◽  
Lung Involvement

scholarly journals THERAPEUTIC APPROACH OF A CASE OF RHEUMATOID ARTHRITIS COMPLICATED WITH RENAL AMYLOIDOSIS IN A YOUNG WOMAN

2017 ◽  
Vol 26 (1) ◽  
pp. 41-44
Author(s):  
Alexandra Burlui ◽  
◽  
Anca Cardoneanu ◽  
Luana Macovei ◽  
Claudia Banu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Acute Phase Proteins ◽  
Certolizumab Pegol ◽  
Renal Involvement ◽  
Active Form ◽  
Scientific Data ◽  
Renal Amyloidosis ◽  
Secondary Amyloidosis ◽  
Inflammatory Biomarker ◽  
Nephrotic Range Proteinuria

Systemic AA amyloidosis is an uncommon complication of rheumatoid arthritis (RA), especially in poorly controlled RA. Renal involvement caused by deposits of amyloid fibrils derived from acute-phase proteins is represented by nephrotic-range proteinuria ultimately leading to renal failure. We report the case of 27-year-old woman diagnosed with RA, with a history of musculoskeletal involvement since the age of 16, manifested by arthritis involving the wrists, knees and ankles; accompanied by severe and persistent inflammatory syndrome. She presented with an active form of RA complicated with secondary amyloidosis manifested by nephrotic-range proteinuria at the time of admission. Renal biopsy confirmed the presence of amyloid deposits. Anti-TNFα therapy with Certolizumab pegol proved effective in reducing proteinuria and inflammatory biomarker levels in our patient. The efficacy of anti TNF-α therapy in RA complicated with renal amyloidosis is demonstrated by recent scientific data.

scholarly journals A CASE OF SMALL INTESTINAL PERFORATION DUE TO SECONDARY AMYLOIDOSIS ACCOMPANIED BY CHRONIC RHEUMATOID ARTHRITIS

2009 ◽  
Vol 70 (5) ◽  
pp. 1397-1401 ◽  
Author(s):  
Kentaro MATSUBARA ◽  
Hiroki HOSHINO ◽  
Minoru KITAGO ◽  
Yoshinobu AKIYAMA ◽  
Fumio SUZUKI ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Intestinal Perforation ◽  
Secondary Amyloidosis ◽  
Chronic Rheumatoid Arthritis ◽  
Small Intestinal
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