scholarly journals Endogenous vascular repair system in cardiovascular disease: The role of endothelial progenitor cells

2019 ◽  
Vol 12 (2) ◽  
Author(s):  
Alexander E Berezin
Keyword(s):  
Cardiovascular Disease ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Repair System ◽  
Vascular Repair ◽  
Endothelial Progenitor

scholarly journals CHIR99021 Augmented the Function of Late Endothelial Progenitor Cells by Preventing Replicative Senescence

2021 ◽  
Vol 22 (9) ◽  
pp. 4796
Author(s):  
Vinoth Kumar Rethineswaran ◽  
Da Yeon Kim ◽  
Yeon-Ju Kim ◽  
WoongBi Jang ◽  
Seung Taek Ji ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Blood Circulation ◽  
Functional Role ◽  
Replicative Senescence ◽  
Endothelial Progenitor ◽  
Vascular Structures ◽  
Gsk 3Β

Endothelial progenitor cells (EPCs) are specialized cells in circulating blood, well known for their ability to form new vascular structures. Aging and various ailments such as diabetes, atherosclerosis and cardiovascular disease make EPCs vulnerable to decreasing in number, which affects their migration, proliferation and angiogenesis. Myocardial ischemia is also linked to a reduced number of EPCs and their endothelial functional role, which hinders proper blood circulation to the myocardium. The current study shows that an aminopyrimidine derivative compound (CHIR99021) induces the inhibition of GSK-3β in cultured late EPCs. GSK-3β inhibition subsequently inhibits mTOR by blocking the phosphorylation of TSC2 and lysosomal localization of mTOR. Furthermore, suppression of GSK-3β activity considerably increased lysosomal activation and autophagy. The activation of lysosomes and autophagy by GSK-3β inhibition not only prevented replicative senescence of the late EPCs but also directed their migration, proliferation and angiogenesis. To conclude, our results demonstrate that lysosome activation and autophagy play a crucial role in blocking the replicative senescence of EPCs and in increasing their endothelial function. Thus, the findings provide an insight towards the treatment of ischemia-associated cardiovascular diseases based on the role of late EPCs.

Endothelial progenitor cells in coronary artery disease

2013 ◽  
Vol 394 (10) ◽  
pp. 1241-1252 ◽  
Author(s):  
Michael Donahue ◽  
Cristina Quintavalle ◽  
Giovanni Alfonso Chiariello ◽  
Gerolama Condorelli ◽  
Carlo Briguori
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Factor ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Vascular Health ◽  
Endothelial Progenitor ◽  
Artery Disease

Abstract In the last two decades a great deal of evidence has been collected on the key role of endothelial progenitor cells (EPC) in the mechanisms of vascular healing. The role of EPC as a marker of vascular health and prognosis of cardiovascular disease is already consolidated. This review aims to examine and evaluate recent data regarding EPC, as biomarkers, prognostic factor and potential therapy in cardiovascular disease.

Endothelial Progenitor Cells as Mediators of the Crosstalk between Vascular Repair and Immunity: Lessons from Systemic Autoimmune Diseases

2018 ◽  
Vol 25 (35) ◽  
pp. 4478-4496 ◽  
Author(s):  
Javier Rodríguez-Carrio ◽  
Patricia López ◽  
Ana Suárez
Keyword(s):  
Vitamin D ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Current Knowledge ◽  
Cell Subset ◽  
Systemic Diseases ◽  
Vascular Repair ◽  
Endothelial Progenitor ◽  
And Function

From the discovery of Endothelial Progenitor Cells (EPC), these bone marrowderived precursors have been placed as crucial mediators of the endothelial repair. Accordingly, altered levels and function of EPC have been found in different scenarios of CV risk. Despite the fact that EPC exhibit important characteristics which support a link of this cell subset with a number of inflammatory and immune networks, little is known on the actual mediators involved and the clinical relevance of these features. Systemic diseases are generally hallmarked by a vascular repair failure and increased cardiovascular disease occurrence, EPC impairment having a pivotal role. Because of their immunemediated etiology, this group of conditions represents an invaluable scenario to unravel the connections between immune dysregulation and EPC dysfunction. In the present review, we summarize the current knowledge regarding the cutting-edge area of the modulation of EPC levels and function by inflammatory cytokines in systemic diseases. We also address the possibility of the available immunomodulatory drugs to counteract this situation. Finally, due to the emerging role of the vitamin D as a common mediator in the immune system and the cardiovascular axis, we cover the topic of the role of vitamin D as a potential player in the inflammatory-mediated EPC dysfunction in systemic diseases.

scholarly journals The Role of Endothelial Progenitor Cells in Vascular Repair after Arterial Injury and Atherosclerotic Plaque Development

2011 ◽  
Vol 29 (2) ◽  
pp. 125-139 ◽  
Author(s):  
Alexandros Briasoulis ◽  
Dimitris Tousoulis ◽  
Charalambos Antoniades ◽  
Nikos Papageorgiou ◽  
Christodoulos Stefanadis
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Atherosclerotic Plaque ◽  
Arterial Injury ◽  
Vascular Repair ◽  
Endothelial Progenitor ◽  
Plaque Development
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