scholarly journals Myoinositol to Total Choline Ratio in Glioblastomas as a Potential Prognostic Factor in Preoperative Magnetic Resonance Spectroscopy

2021 ◽  
Author(s):  
Masanobu KUMON ◽  
Shunsuke NAKAE ◽  
Kazuhiro MURAYAMA ◽  
Takema KATO ◽  
Shigeo OHBA ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Prognostic Factor ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Potential Prognostic Factor ◽  
Preoperative Magnetic Resonance

scholarly journals Myoinositol to total choline ratio in IDH wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy

2020 ◽  
Author(s):  
Masanobu Kumon ◽  
Shunsuke Nakae ◽  
Kazuhiro Murayama ◽  
Takema Kato ◽  
Shigeo Ohba ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Prognostic Factor ◽  
Copy Number ◽  
Progression Free Survival ◽  
Resonance Spectroscopy ◽  
Pathological Findings ◽  
Wild Type ◽  
Free Survival ◽  
Supratentorial Gliomas ◽  
Preoperative Magnetic Resonance

Abstract Background: Isocitrate dehydrogenase (IDH) wild-type gliomas tend to be pathologically defined as glioblastomas. We previously reported that, unlike IDH-mutant gliomas, IDH wild-type gliomas showed significantly lower ratios of myoinositol to total choline (i.e., the Ins/Cho ratio) on magnetic resonance (MR) spectroscopy. Given that IDH-mutant gliomas also have much better prognoses than IDH wild-type gliomas, we hypothesized that this lower Ins/Cho ratio is associated with malignancy in adults with supratentorial gliomas. Therefore, we calculated the Ins/Cho ratios of patients with supratentorial IDH wild-type gliomas and investigated their progression free survival (PFS) and overall survival (OS) to determine its utility as a prognostic marker.Methods: We classified IDH wild-type gliomas (n = 30) into two groups based on the Ins/Cho ratios, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations.Results: Compared with the group with high Ins/Cho ratios, the group with low Ins/Cho ratios had shorter PFS (P = 0.020) and OS (P = 0.037) durations. Multivariate analysis demonstrated that the Ins/Cho ratio correlated significantly with PFS (hazard ratio 0.34, P = 0.027). Conclusion: We conclude that the preoperative Ins/Cho ratio can be used as a novel prognostic factor for IDH wild-type gliomas.

scholarly journals Myoinositol to total choline ratio in IDH wild-type gliomas as a prognostic factor on preoperative magnetic resonance spectroscopy

2020 ◽  
Author(s):  
Masanobu Kumon ◽  
Shunsuke Nakae ◽  
Kazuhiro Murayama ◽  
Takema Kato ◽  
Shigeo Ohba ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Prognostic Factor ◽  
Copy Number ◽  
Progression Free Survival ◽  
Resonance Spectroscopy ◽  
Pathological Findings ◽  
Wild Type ◽  
Free Survival ◽  
Supratentorial Gliomas ◽  
Preoperative Magnetic Resonance

Abstract Background: Isocitrate dehydrogenase (IDH) wild-type gliomas tend to be pathologically defined as glioblastomas. We previously reported that, unlike IDH -mutant gliomas, IDH wild-type gliomas showed significantly lower ratios of myoinositol to total choline (i.e., the Ins/Cho ratio) on magnetic resonance (MR) spectroscopy. Given that IDH -mutant gliomas also have much better prognoses than IDH wild-type gliomas, we hypothesized that this lower Ins/Cho ratio is associated with malignancy in adults with supratentorial gliomas. Therefore, we calculated the Ins/Cho ratios of patients with supratentorial IDH wild-type gliomas and investigated their progression free survival (PFS) and overall survival (OS) to determine its utility as a prognostic marker. Methods: We classified IDH wild-type gliomas (n = 30) into two groups based on the Ins/Cho ratios, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations. Results: Compared with the group with high Ins/Cho ratios, the group with low Ins/Cho ratios had shorter PFS (P = 0.020) and OS (P = 0.037) durations. Multivariate analysis demonstrated that the Ins/Cho ratio corelated significantly with PFS (hazard ratio 0.34, P = 0.027). Conclusion: We conclude that the preoperative Ins/Cho ratio can be used as a novel prognostic factor for IDH wild-type gliomas.

Usefulness of Preoperative Magnetic Resonance Spectroscopy to Improve the Safety of a Living Liver Donor

2021 ◽  
Vol 19 (3) ◽  
pp. 244-249
Author(s):  
Jae Ryong Shim ◽  
Hyo Jung Ko ◽  
Tae Beom Lee ◽  
Byung Hyun Choi ◽  
Kwangho Yang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Liver Donor ◽  
Living Liver Donor ◽  
Preoperative Magnetic Resonance

scholarly journals Usefulness of preoperative magnetic resonance spectroscopy in improving the safety of a living liver donor

2020 ◽  
Vol 34 (1) ◽  
pp. S182-S182
Author(s):  
Jae Ryong Shim ◽  
Hyo Jung Ko ◽  
Tae Beom Lee ◽  
Byung Hyun Choi ◽  
Kwangho Yang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Liver Donor ◽  
Living Liver Donor ◽  
Preoperative Magnetic Resonance

scholarly journals USEFULNESS OF PREOPERATIVE MAGNETIC RESONANCE SPECTROSCOPY FOR IMPROVING DONOR SAFETY

2020 ◽  
Vol 104 (S3) ◽  
pp. S59-S59
Author(s):  
Tae Beom Lee ◽  
Hyo Jung Ko ◽  
Jae Ryong Shim ◽  
Byung Hyun Choi ◽  
Kwangho Yang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Donor Safety ◽  
Preoperative Magnetic Resonance
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