scholarly journals Lipid Core Plaque Distribution Using Near-infrared Spectroscopy Is Consistent with Pathological Evaluation in Carotid Artery Plaques

2020 ◽  
Vol 60 (10) ◽  
pp. 499-506
Author(s):  
Masashi KOTSUGI ◽  
Ichiro NAKAGAWA ◽  
Kinta HATAKEYAMA ◽  
HunSoo PARK ◽  
Fumiya SATO ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Carotid Artery ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Lipid Core ◽  
Pathological Evaluation

scholarly journals First-in-man near-infrared spectroscopy proof of lipid-core embolization during carotid artery stenting

2016 ◽  
Vol 4 ◽  
pp. 915-918 ◽  
Author(s):  
Martin Horvath ◽  
Petr Hajek ◽  
James E. Muller ◽  
Jakub Honek ◽  
Cyril Stechovsky ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Carotid Artery ◽  
Near Infrared Spectroscopy ◽  
Carotid Artery Stenting ◽  
Near Infrared ◽  
Lipid Core

Effect of stenting on the near-infrared spectroscopy-derived lipid core burden index of carotid artery plaque

2019 ◽  
Vol 15 (3) ◽  
pp. e289-e296 ◽  
Author(s):  
Cyril Štěchovský ◽  
Petr Hájek ◽  
Martin Horváth ◽  
Josef Veselka
Keyword(s):  
Infrared Spectroscopy ◽  
Carotid Artery ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Carotid Artery Plaque ◽  
Lipid Core

scholarly journals Carotid artery plaque composition and distribution: near-infrared spectroscopy and intravascular ultrasound analysis

2020 ◽  
Vol 22 (Supplement_F) ◽  
pp. F38-F43
Author(s):  
Martin Horváth ◽  
Petr Hájek ◽  
Cyril Štěchovský ◽  
Jakub Honěk ◽  
Josef Veselka
Keyword(s):  
Infrared Spectroscopy ◽  
Carotid Artery ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Distal Region ◽  
Proximal Region ◽  
Carotid Artery Plaque ◽  
Lipid Core ◽  
Luminal Area

Abstract Most atherosclerotic plaques (APs) form in typical predilection areas of low endothelial shear stress (ESS). On the contrary, previous data hinted that plaques rupture in their proximal parts where accelerated blood flow causes high ESS. It was postulated that high ESS plays an important role in the latter stages of AP formation and in its destabilization. Here, we used near-infrared spectroscopy (NIRS) to analyse the distribution of lipid core based on the presumed exposure to ESS. A total of 117 carotid arteries were evaluated using NIRS and intravascular ultrasound (IVUS) prior to carotid artery stenting. The point of minimal luminal area (MLA) was determined using IVUS. A stepwise analysis of the presence of lipid core was then performed using NIRS. The lipid core presence was quantified as the lipid core burden index (LCBI) within 2 mm wide segments both proximally and distally to the MLA. The analysed vessel was then divided into three 20 mm long thirds (proximal, middle, and distal) for further analysis. The maximal value of LCBI (231.9 ± 245.7) was noted in the segment localized just 2 mm proximally to MLA. The mean LCBI in the middle third was significantly higher than both the proximal (121.4 ± 185.6 vs. 47.0 ± 96.5, P < 0.01) and distal regions (121.4 ± 185.6 vs. 32.4 ± 89.6, P < 0.01). Lipid core was more common in the proximal region when compared with the distal region (mean LCBI 47.0 ± 96.5 vs. 32.4 ± 89.6, P < 0.01).

Association of Serum PCSK9 with Near-Infrared Spectroscopy Derived Lipid Core Burden Index and Long-Term Cardiac Outcome

2019 ◽  
Author(s):  
Sharda S. Anroedh ◽  
Rohit M. Oemrawsingh ◽  
Robert-Jan van Geuns ◽  
Jin M. Cheng ◽  
Hector M. Garcia-Garcia ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Lipid Core ◽  
Cardiac Outcome

Near-infrared spectroscopy carotid plaque characteristics and cerebral embolism in carotid artery stenting

2021 ◽  
Vol 17 (7) ◽  
pp. 599-606
Author(s):  
Ichiro Nakagawa ◽  
Masashi Kotsugi ◽  
Hun Soo Park ◽  
Takanori Furuta ◽  
Fumiya Sato ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Carotid Artery ◽  
Near Infrared Spectroscopy ◽  
Carotid Artery Stenting ◽  
Carotid Plaque ◽  
Near Infrared ◽  
Cerebral Embolism

Disparity between angiographic coronary lesion complexity and lipid core plaques assessed by near-infrared spectroscopy

2012 ◽  
Vol 81 (3) ◽  
pp. 529-537 ◽  
Author(s):  
Todd K. Zynda ◽  
Caleb D. Thompson ◽  
Khiet C. Hoang ◽  
Arnold H. Seto ◽  
Diana Glovaci ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Lipid Core ◽  
Coronary Lesion

Defining thresholds for critical ischemia by using near-infrared spectroscopy in the adult brain

1998 ◽  
Vol 89 (3) ◽  
pp. 389-394 ◽  
Author(s):  
Peter J. Kirkpatrick ◽  
Joseph Lam ◽  
Pippa Al-Rawi ◽  
Piotr Smielewski ◽  
Marek Czosnyka
Keyword(s):  
Infrared Spectroscopy ◽  
Cerebral Ischemia ◽  
Carotid Artery ◽  
Carotid Endarterectomy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Adult Brain ◽  
Content Type ◽  
Signal Changes ◽  
Fine Print

Object. Signal changes in adult extracranial tissues may have a profound effect on cerebral near-infrared spectroscopy (NIRS) measurements. During carotid surgery NIRS signals provide the opportunity to determine the relative contributions from the intra- and extracranial vascular territories, allowing for a more accurate quantification. In this study the authors applied multimodal monitoring methods to patients undergoing carotid endarterectomy and explored the hypothesis that NIRS can define thresholds for cerebral ischemia, provided extracranial NIRS signal changes are identified and removed. Relative criteria for intraoperative severe cerebral ischemia (SCI) were applied to 103 patients undergoing carotid endarterectomy. Methods. One hundred three patients underwent carotid endarterectomy. An intraoperative fall in transcranial Doppler—detected middle cerebral artery flow velocity (%ΔFV) of greater than 60% accompanied by a sustained fall in cortical electrical activity were adopted as criteria for SCI. Ipsilateral frontal NIRS recorded the total difference in concentrations of oxyhemoglobin and deoxyhemoglobin (Total ΔHbdiff). Interrupted time series analysis following clamping of the external carotid artery (ECA) and the internal carotid artery (ICA) allowed the different vascular components of Total ΔHbdiff (ECA ΔHbdiff and ICA ΔHbdiff) to be identified. Data obtained in 76 patients were deemed suitable. A good correlation between %ΔFV and ICA ΔHbdiff (r = 0.73, p < 0.0001) was evident. Sixteen patients (21%) fulfilled the criteria for SCI. All patients who demonstrated an ICA ΔHbdiff of greater than 6.8 µmol/L showed SCI, and in two patients within this group nondisabling watershed infarction developed, as seen on postoperative computerized tomography scans. No patient with an ICA ΔHbdiff less than 5 µmol/L exhibited SCI or suffered a stroke. Within the resolution of the criteria used an ICA ΔHbdiff threshold of 6.8 µmol/L provided 100% specificity for SCI, whereas an ICA ΔHbdiff less than 5 µmol/L was 100% sensitive for excluding SCI. When Total ΔHbdiff was used without removing the ECA component, no thresholds for SCI were apparent. Conclusions. Carotid endarterectomy provides a stable environment for exploring NIRS-quantified thresholds for SCI in the adult head.

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