scholarly journals 52. Clinical Use of Low Molecular Weight Dextran in Neurological Diseases

1967 ◽  
Vol 9 ◽  
pp. 84-84
Author(s):  
Yoshikazu SAITO
Keyword(s):  
Molecular Weight ◽  
Neurological Diseases ◽  
Low Molecular Weight ◽  
Clinical Use

Some Effects of Low Molecular Weight Dextran on Coagulation

1966 ◽  
Vol 15 (01/02) ◽  
pp. 118-130 ◽  
Author(s):  
Marion Dugdale ◽  
J.D Nofzinger ◽  
F Murphey
Keyword(s):  
Molecular Weight ◽  
Protective Action ◽  
Fibrin Clot ◽  
Low Molecular Weight ◽  
Clinical Use ◽  
Excessive Bleeding

SummaryLMDX has been shown to affect adversely the rate of prothrombin consumption during coagulation and the structure of the fibrin clot when present in the concentrations usually recommended for clinical use. Its use in animals with hemostatic defects induced by the pump-oxygenator was accompanied by excessive bleeding. At the same time, however, it conferred some form of protection which led to improved survival. A manner of using LMDX so as to benefit from its protective action without endangering hemostasis is currently under study.

scholarly journals Low Molecular Weight Opioid Peptide Esters Could be Developed as a New Class of Analgesics

2011 ◽  
Vol 5 ◽  
pp. PMC.S6803 ◽  
Author(s):  
Joel S. Goldberg
Keyword(s):  
Molecular Weight ◽  
Chronic Pain ◽  
Opioid Peptide ◽  
Good Manufacturing Practice ◽  
Low Molecular Weight ◽  
Clinical Use ◽  
Plasma Stability ◽  
New Class ◽  
Animal Data ◽  
Peptide Esters

Low molecular weight opioid peptide esters (OPE) could become a class of analgesics with different side effect profiles than current opiates. OPE may have sufficient plasma stability to cross the blood brain barrier (BBB), undergo ester hydrolysis and produce analgesia. OPE of dipeptides, tyr-pro and tyr-gly conjugated to ethanol have a structure similar to the anesthestic agent, etomidate. Based upon the analgesic activity of dipeptide opioids, Lipinski's criteria, and permeability of select GABA esters to cross the BBB, opioid peptides (OP) conjugated to ethanol, cholesterol or 3-glucose are lead recommendations. Preliminary animal data suggests that tyr-pro-ethyl ester crosses the BBB and unexpectedly produces hyperalgesia. Currently, there are no approved OP analgesics available for clinical use. Clinical trials of good manufacturing practice OP administered to patients suffering from chronic pain with indwelling intrathecal pumps could resolve the issue that OP may be superior to opiates and may redirect research.

Chemical and Biological Heterogeneity in Low Molecular Weight Heparins: Implications for Clinical Use and Standardization

1989 ◽  
Vol 15 (04) ◽  
pp. 440-463 ◽  
Author(s):  
Jawed Fareed ◽  
Jeanine Walenga ◽  
Debra Hoppensteadt ◽  
Adrienne Racanelli ◽  
Erwin Coyne
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Clinical Use ◽  
Low Molecular Weight Heparins ◽  
Biological Heterogeneity

A high-performance oil-free backing pump for electron microscopes

1978 ◽  
Vol 36 (1) ◽  
pp. 110-111
Author(s):  
G.K.W. Balkau ◽  
E. Bez ◽  
J.L. Farrant
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Hot Spots ◽  
High Performance ◽  
Carbonaceous Material ◽  
Contamination Rate ◽  
Low Molecular Weight ◽  
Principal Source ◽  
Rotary Pumps ◽  
Electron Microscopes

The earliest account of the contamination of electron microscope specimens by the deposition of carbonaceous material during electron irradiation was published in 1947 by Watson who was then working in Canada. It was soon established that this carbonaceous material is formed from organic vapours, and it is now recognized that the principal source is the oil-sealed rotary pumps which provide the backing vacuum. It has been shown that the organic vapours consist of low molecular weight fragments of oil molecules which have been degraded at hot spots produced by friction between the vanes and the surfaces on which they slide. As satisfactory oil-free pumps are unavailable, it is standard electron microscope practice to reduce the partial pressure of organic vapours in the microscope in the vicinity of the specimen by using liquid-nitrogen cooled anti-contamination devices. Traps of this type are sufficient to reduce the contamination rate to about 0.1 Å per min, which is tolerable for many investigations.

Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders

1998 ◽  
Vol 1 (5) ◽  
pp. 166-174 ◽  
Author(s):  
Evelyn R Hermes De Santis ◽  
Betsy S Laumeister ◽  
Vidhu Bansal ◽  
Vandana Kataria ◽  
Preeti Loomba ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention And Treatment
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