scholarly journals Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas

2013 ◽  
Vol 53 (7) ◽  
pp. 496-500 ◽  
Author(s):  
Tae ITO-YAMASHITA ◽  
Yoko NAKASU ◽  
Koichi MITSUYA ◽  
Yoshihito MIZOKAMI ◽  
Hiroki NAMBA
Keyword(s):  
Magnetic Resonance ◽  
Tumor Progression ◽  
Signal Intensity ◽  
Magnetic Resonance Images ◽  
Inversion Recovery ◽  
Intensity Increase ◽  
High Grade ◽  
Resection Cavity ◽  
Fluid Attenuated Inversion Recovery ◽  
High Grade Gliomas

Diagnostic Ability of Fluid-Attenuated Inversion Recovery MR Imaging to Detect Remnant or Recurrent Meningiomas after Resection

2012 ◽  
Vol 25 (2) ◽  
pp. 163-171 ◽  
Author(s):  
H. Mori ◽  
A. Kunimatsu ◽  
O. Abe ◽  
H. Sasaki ◽  
H. Takao ◽  
...  
Keyword(s):  
Qualitative Analysis ◽  
Tumor Progression ◽  
Evaluation Criteria ◽  
Region Of Interest ◽  
Inversion Recovery ◽  
Recurrent Tumor ◽  
Resection Cavity ◽  
Fluid Attenuated Inversion Recovery ◽  
Remnant Tumor

It has been suggested that a difference in signal intensity (SI) between the resection cavity and normal cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) in partially resected gliomas indicates subsequent or coincident tumor progression. We considered that this would hold true for resected meningiomas as well. Hence, we aimed to assess whether or not such a difference in the SI during the follow-up evaluation helps predict residual or recurrent tumor in resected meningiomas. We evaluated 63 patients with resected meningiomas. The SI within the resection cavity observed on FLAIR images was qualitatively and quantitatively assessed during follow-up. Qualitative analysis comprised visual comparison of the SI in the resection cavity with that of normal CSF by neuroradiologists. The SI in the resection cavity was quantitatively assessed by region of interest (ROI) analysis and normalized against the background noise and CSF SI. Normalized SI recorded during follow-up was compared with that recorded immediately after resection. Tumor progression was defined as a 20% or greater increase in the diameter of the longest residual or recurrent meningioma (Response Evaluation Criteria in Solid Tumors). The sensitivity and specificity of the elevated SI in the resection cavity for indicating residual or recurrent tumor were calculated. Qualitative analysis by FLAIR MRI showed that patients with remnant tumor following surgery had a prolonged SI increase in the resection cavity. Further, SI increase could not always be observed before recurrence, and both SI increase and regrowth remnant/recurrence could be detected in the same MRI examination. In resected meningiomas, leakage of tumor elements into the resection cavity, presumably tumor cells, manifests as an SI increase on FLAIR images and indicates residual or recurrent tumor. However, unlike the previous reports on partially resected gliomas, we concluded that the SI change does not always precede tumor progression or recurrence.

Perfusion imaging of high-grade gliomas: a comparison between contrast harmonic and magnetic resonance imaging

2004 ◽  
Vol 101 (4) ◽  
pp. 700-703 ◽  
Author(s):  
Judith U. Harrer ◽  
Walter Möller-Hartmann ◽  
Markus F. Oertel ◽  
Christof Klötzsch
Keyword(s):  
Magnetic Resonance ◽  
Brain Tissue ◽  
Signal Intensity ◽  
Cerebral Blood Volume ◽  
Antiangiogenic Therapy ◽  
Similar Data ◽  
High Grade ◽  
Imaging Results ◽  
Regional Cerebral Blood Volume ◽  
High Grade Gliomas

✓ Transcranial contrast harmonic (CH) imaging is emerging as a promising tool for the evaluation of brain perfusion. The authors report on two cases of histologically proven high-grade gliomas evaluated using CH imaging in comparison to perfusion magnetic resonance (pMR) imaging. In both cases, pMR imaging results demonstrated a massive decrease in signal intensity and an elevated regional cerebral blood volume (rCBV) in the tumor region; however, signal decrease was less prominent and rCBV was lower in healthy brain tissue. In one patient, the rCBV ratio of tumor/brain was 5.0 and the maximal signal decay occurred 3.1 times deeper in the tumor than in the healthy brain tissue. Results of an ultrasonography examination using CH imaging revealed similar data: the tumor/brain ratio for the area under the curve, a parameter corresponding to rCBV, was 4.1. The maximal signal intensity in the tumor was 3.3 times greater than in adjacent healthy brain. Comparable data were obtained in a second patient. Taken together, these findings indicate that CH imaging may be a valuable alternative to pMR imaging. This new, cost-effective bedside ultrasonic technique could be helpful not only as a means of noninvasive staging of gliomas but also as a follow-up imaging modality to evaluate postoperative tumor recurrence or response to antiangiogenic therapy.

Subvoxel Image Registration of Multislice (2D) Magnetic Resonance Images in Patients with High-grade Gliomas of the Brain

2002 ◽  
Vol 57 (12) ◽  
pp. 1098-1108 ◽  
Author(s):  
A Oatridge ◽  
J.V Hajnal ◽  
N Saeed ◽  
E.S Newlands ◽  
W.L Curati ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Image Registration ◽  
Magnetic Resonance Images ◽  
High Grade ◽  
High Grade Gliomas ◽  
The Brain

scholarly journals Multiple sclerosis: High prevalence of the ‘central vein’ sign in white matter lesions on susceptibility-weighted images

2018 ◽  
Vol 31 (4) ◽  
pp. 356-361 ◽  
Author(s):  
Gianvincenzo Sparacia ◽  
Francesco Agnello ◽  
Angelo Gambino ◽  
Martina Sciortino ◽  
Massimo Midiri
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetic Resonance ◽  
Small Vessel Disease ◽  
White Matter Lesions ◽  
Magnetic Resonance Images ◽  
Inversion Recovery ◽  
Central Vein ◽  
Fluid Attenuated Inversion Recovery ◽  
The Difference

Purpose The aim of this study was to determine the occurrence and distribution of the ‘central vein’ sign in white matter lesions on susceptibility-weighted magnetic resonance images in patients with multiple sclerosis (MS) and cerebral small vessel disease (CSVD). Materials and methods T2-weighted and fluid-attenuated inversion recovery magnetic resonance images of 19 MS patients and 19 patients affected by CSVD were analysed for the presence and localisation of focal hyperintense white matter lesions. Lesions were subdivided into periventricular or non-periventricular (juxtacortical, subcortical, deep white matter and cerebellar) distributed. The number and localisation of lesions presenting with the central vein sign were recorded and compared between MS and CSVD lesions. Results A total of 313 MS patients and 75 CSVD lesions were identified on T2-weighted and fluid-attenuated inversion recovery magnetic resonance images. The central vein sign was found in 128 MS lesions (40.9%), and the majority of them (71/128, 55.5%) had a periventricular distribution. The central vein sign was found in 22 out of 75 (29.3%) CSVD lesions, and periventricular distribution was seen in six out of 22 (27.2%) CSVD lesions. The difference in the proportion of white matter hyperintense lesions that presented with the central vein sign on susceptibility-weighted images in patients with MS and CSVD was statistically different, and a significantly higher number of MS patients presented with lesions with the central vein sign compared to CSVD patients. Conclusion The presence of the central vein sign on susceptibility-weighted images for MS lesions improves the understanding of the periventricular distribution of MS lesions and could contribute as adjunctive diagnostic criteria for MS disease.

Cerebral Swelling after Normothermic Cardiopulmonary Bypass 

1998 ◽  
Vol 88 (2) ◽  
pp. 340-345 ◽  
Author(s):  
David N. F. Harris ◽  
Angela Oatridge ◽  
Darryl Dob ◽  
Peter L. C. Smith ◽  
Kenneth M. Taylor ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Magnetic Resonance ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Magnetic Resonance Images ◽  
Inversion Recovery ◽  
Ventricular Size ◽  
Fluid Attenuated Inversion Recovery

Background Marked cerebral swelling visible on magnetic resonance images has been found immediately after hypothermic (28 degrees C) cardiopulmonary bypass. The mechanism is unknown, but indices of cerebral ischemia are seen during rewarming from hypothermic bypass that are not present with normothermic bypass (37 degrees C). Methods T1-weighted and fluid-attenuated inversion recovery magnetic resonance images were taken of seven patients undergoing routine coronary artery bypass surgery before, 1 h, and 7 days after the operation using normothermic bypass. Results Marked cerebral swelling was seen in fluid-attenuated inversion recovery images in five of seven patients 1 h after bypass. Scans in four patients taken 7 days after bypass showed that the cerebral swelling had returned to normal. There was no change in cerebral ventricular size, and all patients had uncomplicated postoperative courses. Conclusions Normothermic bypass is followed by acute postoperative cerebral swelling. However, the amount of swelling was similar to that found in a previous study after hypothermic bypass. The mechanism of swelling is still obscure, and its relation to neurologic outcome is unknown.

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