scholarly journals Delayed Radiation Necrosis With Extensive Brain Edema After Gamma Knife Radiosurgery for Multiple Cerebral Cavernous Malformations-Case Report-

2003 ◽  
Vol 43 (8) ◽  
pp. 391-395 ◽  
Author(s):  
Nobuo TAKENAKA ◽  
Tomoyuki IMANISHI ◽  
Hikaru SASAKI ◽  
Kenji SHIMAZAKI ◽  
Hitoshi SUGIURA ◽  
...  
Keyword(s):  
Case Report ◽  
Brain Edema ◽  
Gamma Knife ◽  
Radiation Necrosis ◽  
Gamma Knife Radiosurgery ◽  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations

scholarly journals Displacement of Gray Matter and Incidence of Seizures in Patients with Cerebral Cavernous Malformations

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1872
Author(s):  
Chi-Jen Chou ◽  
Cheng-Chia Lee ◽  
Ching-Jen Chen ◽  
Huai-Che Yang ◽  
Syu-Jyun Peng
Keyword(s):  
Image Analysis ◽  
Gamma Knife ◽  
Gray Matter ◽  
Gamma Knife Radiosurgery ◽  
Initial Presentation ◽  
Cerebral Cavernous Malformations ◽  
Strongly Correlated ◽  
Cavernous Malformations ◽  
Common Presentation ◽  
Limbic Lobe

Seizures are the most common presentation in patients with cerebral cavernous malformations (CCMs). Based on the hypothesis that the volume or proportion of gray matter (GM) displaced by CCMs is associated with the risk of seizure, we developed an algorithm by which to quantify the volume and proportion of displaced GM and the risk of seizure. Image analysis was conducted on 111 patients with solitary CCMs (divided into seizure and nonseizure groups) from our gamma knife radiosurgery (GKRS) database from February 2005 and March 2020. The CCM algorithm proved effective in quantifying the GM and CCM using T1WI MRI images. In the seizure group, 11 of the 12 patients exhibited seizures at the initial presentation, and all CCMs in the seizure group were supratentorial. The location of the limbic lobe within the CCM was significantly associated with the risk of seizure (OR = 19.6, p = 0.02). The risk of seizure increased when the proportion of GM displaced by the CCM exceeded 31%. It was also strongly correlated with the volume of displaced GM. The volume and proportion of displaced GM were both positively correlated with the risk of seizure presentation/development and thus could be used to guide seizure prophylaxis in CCM patients.

scholarly journals Brain Edema after Repeat Gamma Knife Radiosurgery for a Large Arteriovenous Malformation: A Case Report

2016 ◽  
Vol 25 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Joo Whan Kim ◽  
Hyun-Tai Chung ◽  
Moon Hee Han ◽  
Dong Gyu Kim ◽  
Sun Ha Paek
Keyword(s):  
Case Report ◽  
Arteriovenous Malformation ◽  
Brain Edema ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery

scholarly journals Case Report: Dacomitinib Overcomes Osimertinib Resistance in NSCLC Patient Harboring L718Q Mutation: A Case Report

2021 ◽  
Vol 11 ◽  
Author(s):  
Qian Shen ◽  
Jingjing Qu ◽  
Zhen Chen ◽  
Jianying Zhou
Keyword(s):  
Case Report ◽  
Disease Progression ◽  
Gamma Knife ◽  
Parietal Lobe ◽  
Brain Mri ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Egfr Mutations ◽  
Small Subset ◽  
Small Cell Lung

BackgroundAdvanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations has been successfully treated with tyrosine kinase inhibitors (TKIs). However, resistance to osimertinib, a third-generation TKI, can be difficult to overcome in this small subset of patients and is attributed to secondary resistant mutations. Here, we report a case of acquired EGFR L858R/L718Q mutation with advanced NSCLC that resistant to osimertinib, which was successfully overcome using dacomitinib.Case PresentationA 64-year-old non-smoker woman was diagnosed with stage IV non-small cell lung adenocarcinoma with EGFR L858R mutation and brain metastasis in November 2018. Treatment with gefitinib and gamma knife radiosurgery was started as the first-line treatment. After 7 months, she experienced disease progression with increased primary lung lesions and switched to osimertinib based on an acquired EGFR T790M mutation. After another 4 months, the disease progressed, and she was switched to chemotherapy. During chemotherapy, brain MRI showed an increasing number of parietal lobe metastases. Hence, gamma knife radiosurgery was performed again. After 12 months, the disease progression resumed, and an EGFR L718Q mutation was found on biopsy. The patient was then challenged with dacomitinib, and the disease was partially responsive and under control for 6 months.ConclusionCurrently, there are no established guidelines for overcoming osimertinib resistance caused by the L718Q mutation. The acquired EGFR L718Q mutation in subsequent resistance to osimertinib could be overcome using dacomitinib, indicating a promising treatment option in the clinic.

scholarly journals MLTI-15. A CASE SERIES OF PRE-OPERATIVE GAMMA-KNIFE RADIOSURGERY FOR RESECTABLE BRAIN METASTASES

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i17-i17
Author(s):  
Tatsuya Takezaki ◽  
Haruaki Yamamoto ◽  
Naoki Shinojima ◽  
Jun-ichiro Kuroda ◽  
Shigeo Yamashiro ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Systemic Treatment ◽  
Radiation Necrosis ◽  
Gamma Knife Radiosurgery ◽  
Case Series ◽  
Phase 3 ◽  
Optimal Sequence ◽  
Median Margin

Abstract Recent advances in the systemic treatment of various cancers have resulted in longer survival and higher incidence of brain metastases. Phase 3 trials in north America and in Japan have demonstrated that stereotactic radiosurgery will be a standard adjuvant modality following surgery for resectable brain metastases. However, we don’t know the optimal sequence of this combination therapy. We hypothesized that pre-operative stereotactic radiosurgery for resectable brain metastases provides favorable rates of local control, overall survival, leptomeningeal dissemination and symptomatic radiation necrosis. We have experienced 4 cases of resected brain metastases within 1–7 days after Gamma-knife surgery (median margin dose:22Gy) and have been following their clinical course. We will show the repressive cases.

scholarly journals A novel PDCD10 gene mutation in cerebral cavernous malformations: a case report and review of the literature

2019 ◽  
Vol Volume 12 ◽  
pp. 1127-1132 ◽  
Author(s):  
Weiwei Yu ◽  
Haiqiang Jin ◽  
Qian You ◽  
Ding Nan ◽  
Yining Huang
Keyword(s):  
Case Report ◽  
Gene Mutation ◽  
Cerebral Cavernous Malformations ◽  
Review Of The Literature ◽  
Cavernous Malformations

Primary cavernous sinus malignant lymphoma treated by gamma knife radiosurgery: Case report and review of the literature

1996 ◽  
Vol 46 (3) ◽  
pp. 272-278 ◽  
Author(s):  
Hirofumi Nakatomi ◽  
Tomio Sasaki ◽  
Shunsuke Kawamoto ◽  
Takamitsu Fujimaki ◽  
Kazuhide Furuya ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Lymphoma ◽  
Gamma Knife ◽  
Cavernous Sinus ◽  
Gamma Knife Radiosurgery ◽  
Review Of The Literature
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